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Biochemical Considerations in the Design of Radiopharmaceuticals

  • Chapter
Diagnostic Imaging in Medicine

Part of the book series: NATO ASI Series ((NSSE,volume 61))

Abstract

The goal of radiopharmaceutical chemistry is to design and develop radiotracers targeted to an organ or function whose activity kinetics in tissue can be detected externally by a gamma or a positron device. Three years ago, Eckelman and Reba (1) divided radiopharmaceuticals into the general categories of specific and non-specific agents. The specific radiopharmaceuticals are the tracers that follow a biochemical pathway or are involved in a particular interaction, for example metabolic substrates, drugs or analogs, and antibodies, Non-specific radiopharmaceuticals include radiolabeled liposomes, cells, microspheres, perfusion agents, inert gases, ethers, alcohols or thallium-201. The design and development of both types of radiopharmaceuticals are important. In the case of myocardial imaging agents, a perfusion agent that will enable differentiation of various stages of ischemia and infarction is as essential as a specific tracer that will reflect metabolism since both perfusion and metabolic functions change with injury.

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Authors and Affiliations

  1. Massachusetts General Hospital, 02114, Boston, MA, USA

    David R. Elmaleh, E. Livni & S. Levy

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  1. David R. Elmaleh
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  2. E. Livni
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  3. S. Levy
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Editor information

Editors and Affiliations

  1. Division of Nuclear Medicine, George Washington University Medical Center, 901 Twenty-Third Street, N.W. Washington DC, 20037, USA

    Richard C. Reba M.D. (Professor of Radiology and Medicine Director) (Professor of Radiology and Medicine Director)

  2. Division of Radiation Physics, George Washington University Medical Center, 901 Twenty-Third Street, N.W. Washington DC, 20037, USA

    David J. Goodenough Ph.D. (Director) (Director)

  3. Department of the Army, Washington DC, 20310, USA

    Harold F. Davidson M.S. (Consultant, Office of the Director of Army Research) (Consultant, Office of the Director of Army Research)

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© 1983 Martinus Nijhoff Publishers, The Hague

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Elmaleh, D.R., Livni, E., Levy, S. (1983). Biochemical Considerations in the Design of Radiopharmaceuticals. In: Reba, R.C., Goodenough, D.J., Davidson, H.F. (eds) Diagnostic Imaging in Medicine. NATO ASI Series, vol 61. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6810-3_14

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  • DOI: https://doi.org/10.1007/978-94-009-6810-3_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6812-7

  • Online ISBN: 978-94-009-6810-3

  • eBook Packages: Springer Book Archive

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