Structure-Activity Relationships among Antitumour Quinones
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The quinone function appears with considerable frequency among compounds which demonstrate clinical and pre-clinical antitumor activity. Sources of these compounds include fermentation products, synthetic materials and plant products. Familiar names among antitumor quinones include daunorubicin, adriamycin, mitomycin C, streptonigrin, lapachol, trenimon and carbazilquinone. New quinoid compounds currently under investigation by the National Cancer Institute (NCI) in the United States are AZQ, dihydroxyanthracenedione, aclacinomycin A and 7-OMEN.
KeywordsP388 Leukemia Dihydroxybenzene Isomer Quinoid Compound Jules Bordet Institute Substancial P388 Activity
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