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Role of the Slow Inward Current in the Genesis of Cardiac Arrhythmias

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Frontiers of Cardiac Electrophysiology

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 19))

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Abstract

Hodgkin and Katz[l] demonstrated that a large and relatively specific increase in the membrane permeability to sodium ions accounted for the amplitude and rate of voltage change of the depolarization phase of squid nerve action potentials. Using the voltage-clamp technique, Hodgkin and Huxley [2] analyzed the currents underlying the nerve action potential. They described two constituents — an inward sodium flow followed by an outward potassium flow — and formulated equations to describe how these currents vary with transmembrane voltage potential and time.

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  1. Douglas P. Zipes
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  2. Robert F. Gilmour Jr
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  1. Serivce of Cardiology and Department of Electrocardiography, Ramos Mejia Hospital, Urquiza 609, 1221, Buenos Aires, Argentina

    Mauricio B. Rosenbaum  & Marcelo V. Elizari  & 

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Zipes, D.P., Gilmour, R.F. (1983). Role of the Slow Inward Current in the Genesis of Cardiac Arrhythmias. In: Rosenbaum, M.B., Elizari, M.V. (eds) Frontiers of Cardiac Electrophysiology. Developments in Cardiovascular Medicine, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6781-6_15

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