Abstract
Prior to the advent of chronic hemodialysis, infection was frequently a terminal or preterminal event in patients with end-stage renal failure. During the last decade, better hemodialysis techniques coupled with general advances in medical therapy have improved the prognosis (1–3). Nevertheless, infectious complications continue to be a major medical threat to patients receiving maintenance hemodialysis (4–10). It is unquestionable that the most common type of infections are those related to the blood access device. In this chapter we will review incidence and type of infectious complications that occur in patients undergoing chronic hemodialysis. It seems important to emphasize at the beginning that most of the infections seen in patients with severe renal failure can be accounted for by commonly occurring bacteria and not by unusual or opportunistic organisms. The repetitive exposure of these patients to infectious risk factors during hemodialysis appears of major importance in determining the infectious complications observed.
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References
Gross JB, Keane WF, McDonald AK: Survival and rehabilitation of patients on home hemodialysis. Ann Intern Med 78: 341, 1973
Burton BT, Krueger KK, Bryan FA Jr: National registry of long-term dialysis patients. JAMA 218: 718, 1971
Lewis EJ, Foster DM, de la Puente J, Scurlock C: Survival data for patients undergoing chronic intermittent hemodialysis. Ann Intern Med 70: 311, 1969
Montgomerie JZ, Kalmanson GM, Guze LB: Renal failure and infection. Medicine 47: 1, 1968
Blagg CR, Hickman RO, Eschbach JW, Scribner BH: Home hemodialysis: Six years experience. N Engl J Med 283: 1126, 1970
Gurland HJ, Brunner FP, v Dehn H, Harlen H, Parsons FM, Scharer K: Combined report on regular dialysis and transplantation in Europe III, 1972. Proc Eur Dial Transpl Assoc 10: XVII, 1973
Lowrie EG, Lazarus JM, Mogelin AJ, Baily FL, Hampers CL, Wilson RE, Merrill JP: Survival of patients undergoing chronic hemodialysis and renal transplantation. N Engl J Med 288: 863, 1973
Keane WF, Shapiro FL, Raij L: Incidence and type of infections occurring in 445 chronic hemodialysis patients. Trans Am Soc Artif Intern Organ 23: 41, 1977
Dobkin JE, Miller MH, Steighigel NH: Septicemia in patients on chronic hemodialysis. Ann Intern Med 88: 28, 1978
Nsouli KA, Lazarus JM, Schoenbaum SC, Gottlieb MN, Lowrie EG, Shocair M: Bacteremic infection in hemodialysis. Arch Intern Med 139: 1255, 1979
Dammin GJ, Couch NP, Murray JE: Prolonged survival of skin homografts in uremia patients. Ann NY Acad Sci 64: 967, 1957
Mannick JA, Powers JH, Mithoefer J, Ferrebee JW: Renal transplantation in azotemic dogs. Surgery 47: 340, 1960
Morrison AB, Maness K, Tawes R: Skin homograft survival in chronic renal insufficiency. Arch Pathol 75: 139, 1963
Casciani CU, DeSimone C, Bonini S: Immunological aspects of chronic uremia. Kidney Int 13 (Suppl £J: S49, 1978
Hosking CS, Atkins RC, Scott DR, Holdsworth SR, Fitzgerald MG, Shelton MJ: Immune and phagocytic functions in patients on maintenance hemodialysis and posttransplantation. Clin Nephrol 6: 501, 1976
Wilson WEC, Kirkpatrick CH, Talmage DW: Suppression of immunologic responsiveness in uremia. Ann Intern Med 61: 1, 1965
Jordan MC, Rousseau WE, Tegtmeier GE, Noble GR, Muth RG, Chin TDY: Immunogenicity of inactivated influenza virus vaccine in chronic renal failure. Ann Intern Med 79: 790, 1973
Stoloff IL, Stout R, Myerson RM, Havens WP Jr: Production of antibody in patients with uremia. N Engl J Med 259: 320, 1958
Spencer ES: Cytomegalovirus antibody in uremic patients prior to renal transplantation. Scand J Infect Dis 6: 1, 1954
Naroqi S, Jackson GG, Jonasson O, Yamashiroya HM: Prospective study of prevalence, incidence and source of herpesvirus infections in patients with renal allografts. J Infect Dis 136: 531, 1977
Osanloo EO, Berlin BS, Popli S, Ing TS, Cummings JE, Gandhi VC, Geis WP, Hano JE: Antibody response to influenza vaccination in patients with chronic renal failure. Kidney Int 14: 614, 1978
Kleinknecht C, Margolis A, Bonnissol C, Gaiffe M, Sahyoun S, Broyer M: Serum antibodies before and after immunization in haemodialysed children. Proc Eur Dial Transpl Assoc 14: 209, 1977
Friedman EA, Beyer MM, Hirsch SR, Schiffman G: Intact anibody response to pneumococcal capsular polysaccharides in uremia and diabetes. JAMA 244: 2310, 1980
Simberkoff MS, Schiffman G, Katz L, Spicehandler J, Moldover NH, Rahal JJ: Diminished radioimmunoassay antibody responses and opsonic titers in chronic hemodialysis patients. Proc 11th Int Congr Chemotherapy and 19th Interscience Conf on Antimicrobial Agents and Chemotherapy. Volume II, edited by Nelson JD and Gassi C, Washington, D.C., Am Soc Microbiol 1980, p 851
Dailey MP, Schiffman G, Piering WF, Hoffman RG, Rytel MW: Response of renal allograft recipents and dialysis patients to pneumococcal vaccine. Proc 11th Int Congr Chemotherapy and 19th Interscience Conf on Antimicrobial Agents and Chemotherapy. Volume II, edited by Nelson JD and Gassi C, Washington, DC, Am Soc Microbiol 1980, p 854
Crosson JT, Moulds J, Comty CM, Polesky HF: A clinical study of anti-NDP in the sera of patients in a large repetitive hemodialysis program. Kidney Int 10: 463, 1976
Kaehny WD, Miller GE, White WL: Relationship between dialyzer reuse and the presence of anti-N-like antibodies in chronic hemodialysis patients. Kidney Int 12: 59, 1977
Howell ED, Perkins HA: Anti-N-like antibodies in the sera of patients undergoing chronic hemodialysis. Vox Sang 23: 291, 1972
Nolph KD, Husted FC, Sharp GC, Siemsen AW: Antibodies to nuclear antigens in patients undergoing long- term hemodialysis. Am J Med 60: 673, 1976
Ting A, Morris PJ: Reactivity of autolymphocytotoxic antibodies from dialysis patients with lymphocytes from chronic lymphocytic leukemia (CLL) patients. Transplantation 25: 31, 1978
Kauffman CA, Manzler AD, Phair JP: Cell-Mediated immunity in patients on long-term haemodialysis. Clin Exp Immunol 22: 54, 1975
Newberry WM, Sanford JP: Defective cellular immunity in renal failure: Depression of reactivity of lymphocytes to phytohemagglutinin by renal failure serum. J Clin Invest 50: 1262, 1971
Touraine Jl, Touraine F, Revillard JP, Brochier J, Traeger J: T-Lymphocytes and serum inhibitors of cell-mediated immunity in renal insufficiency. Nephron 14: 195, 1975
Harris J, Sengar D, Rashid A, Hyslop D, Green L, Goldstein Al: Immunodeficiency in chronic uremia. Transplantation 20: 176, 1975
Hoy WE, Cestero RVM, Freeman RB: Deficiency of T and B lymphocytes in uremic subjects and partial improvement with maintenance hemodialysis. Nephron 20: 182, 1978
Hurst KS, Saldanhar LF, Steinberg SM, Galen MA, Lowrie EG, Gagneux SA, Lazarus JM, Strom TB, Carpenter CB, Merrill JP: The effects of varying dialysis regimens on lymphocyte stimulation. Trans Am Soc Artif Intern Organs 21: 329, 1975
Sengar D, Rashid A, Perelmutter L, Harris JE: Lymphocytotoxins and mixed leucocyte culture blocking factor activity in the plasma of uraemic patients undergoing haemodialysis. Clin Exp Immunol 20: 249, 1975
Selroos O, Pasternack A, Virolainen M: Skin test sensitivity and antigen induced lymphocyte transformation in uraemia. Clin Exp Immunol 14: 365, 1973
Kasakura S, Lowenstein L: The effect of uremic blood on mixed leukocyte reactions and on cultures of leukocytes with phytohemagglutinin. Transplantation 5: 283, 1967
Fehrman I, Ringden O, Bergström J: MLC-blocking factions in uremic sera. Clin Nephrol 14: 183, 1980
Raskova J, Morrison AB. Humoral inhibitors of the immune response in uremia. I. Effect of serum and of the supernatant of spleen cultures from uremic rats on the mixed lymphocyte reaction. Lab Invest 38: 103, 1978
Raska K, Morrison AB, Raskova J: Humoral inhibitors of the immune response in uremia. III. The immunosuppressive factor of uremic rat serum is a very low density lipoprotein. Lab Invest 42: 636, 1980
Sanders CV Jr, Luby JP, Sanford JP, Hull AR: Suppression of interferon responses in lymphocytes from patients with uremia. J Lab Clin Med 77: 768, 1971
Sengar D, Rashid A, Harris J: In vitro cellular immunity and in vivo delayed hypersensitivity in uremic patients maintained on hemodialysis. Int Arch Allergy Appl Immunol 47: 829, 1974
Bansal VK, Popli S, Pickering J, Ing TS, Hans JE: Protein calorie malnutrition and cutaneous anergy in hemodialysis maintained patients. Am J Clin Nutr 33: 1608, 1980
Van Epps DE, Palmer DL, Williams RC: Characterization of serum inhibitors of neutrophil Chemotaxis associated with anergy. J Immunol 113: 189, 1974
Van Epps DE, Strickland RC, Williams RC: Inhibitors of leukocyte Chemotaxis in alcoholic liver disease. Am J Med 59: 200, 1975
Goldblum SE, van Epps DE, Reed WP: Serum inhibitor of C5 fragment-mediated polymorphonuclear leukocyte Chemotaxis associated with chronic hemodialysis. J Clin Invest 64: 255, 1979
Dreizen S: Nutrition and the immune response -a review. Int J Vitam Nutr Res 49: 220, 1979
Hamet P, Stouder DA, Ginn HE, Hardman JG, Liddle GW: Studies of the elevated extracellular concentration of cyclic AMP in uremic man. J Clin Invest 56: 339, 1975
Dobbelstein H, Korner WF, Mempel W, Grosse-Wilde H, Edel HH: Vitamin B6 deficiency in uremia and its implications for the depression of immune responses. Kidney Int 5:223, 1974
Lang PA, Ritzmann SE, Merian FL, Lawrence MC, Levin WC, Gregory R: Cellular evolution in induced inflammation in uremic patients. Tex Rep Biol Med 24: 107, 1966
Buchanan WW, Klinenberg JR, Seegmiller JE: The inflammatory response to injected microcrystalline monosodium urate in normal hyperuricemic, gouty and uremic subjects. Arthritis Rheum 8: 361, 1965
Hanicki Z, Cichocki T, Komorowska Z, Sulowicz W, Smolenski O: Some aspects of cellular immunity in untreated and maintenance hemodialysis patients. Nephron 23: 273, 1979
Baum J, Cestero RVM, Freeman RB: Chemotaxis of the polymorphonuclear leukocyte and delayed hypersensitivity in uremia. Kidney Int 7 (suppl 2):S147, 1975
Salant DJ, Glover AM, Anderson R, Meyers AM, Rabkin R, Myburgh JA, Robson AR: Depressed neutrophil Chemotaxis in patients with chronic renal failure and after renal transplantation. J Lab Clin Med 88: 536, 1976
Siriwatratananonta P, Sinsakul V, Stern K, Slavin RG: Defective Chemotaxis in uremia. J Lab Clin Med 92: 402, 1978
Greene WH, Ray C, Mauer SM, Quie PG: The effect of hemodialysis on neutrophil chemotactic responsiveness. J Lab Clin Med 88: 971, 1976
Craddock PR, Fehr J, Dalmasso AP, Brigham KL, Jacob HS: Hemodialysis leukopenia: Pulmonary vascular leu- kostasis resulting from complement activation by dialyzer cellophane membranes. J. Clin Invest 59: 879, 1977
Guckian JC, Karrh LR, Copeland JL, McCoy J: Phagocytosis by polymorphonuclear leukocytes in patients with renal faillure on chronic hemodialysis. Tex Rep Biol Med 29: 193, 1971
Brogan TD: Phagocytosis by polymorphonuclear leucocytes from patients with renal failure. Br Med J 3: 596, 1967
Chreitien JH, Garagusi VF: Phagocytosis and nitroblue tetrazolium reduction in uremia. Experientia 29: 612, 1973
Hallgren R, Fjellstrom KE, Hokansson L, Vengi P: The serum-independent uptake of IgG-coated particles by polymorphonuclear leukocytes from uremic patients on regular dialysis treatment. J Lab Clin Med 94: 277, 1979
Khan F, Khan AF, Papagaroufalis C, Marman J, Khan P, Evans HE: Reversible defect of neutrophil Chemotaxis and random migration in primary hyperparathyroidism. J Clin Endocrinol Metab 48: 582, 1979
Tuma SA, Martin RR, Mallette LE, Eknoyan G: Augmented polymorphonuclear chemiluminescence in patients with secondary hyperparathyroidism. J Lab Clin Med 97: 291, 1981
Laknborg G, Berghim L, Ahlgren T, Groth CG, Lundgren G, Tillegard A: Reticuloendothelial function in human renal allograft recipients. Transplantation 28: 111, 1979
Ringoir S, Van Looy L, Van de Heyning P, Leroux-Roels G: Impairment of phagocytic activity of macrophages as studied by the skin window test in patients on regular hemodialysis treatment. Clin Nephrol 4: 234, 1975
Urbanitz D, Sieberth HG: Impaired phagocytic activity of human monocytes in respect to reduced antibacterial resistance in uremia. Clin Nephrol 75: 13, 1975
Jorstad S, Viken KE: Inhibitory effects of plasma from uraemic patients on human mononuclear phagocytes cultures in vitro. Acta Pathol Microbiol Scand [C] 85:169,
Jorstad S, Kvernes S: Uraemic toxins of high molecular weight inhibiting human mononuclear phagocytes cultured in vitro. Acta Pathol Microbiol Scand [C] 86:221,
London WT, DiFiglia M, Sutnick AI, Blumberg BS: An epidemic of hepatitis in a chronic-hemodialysis unit. Australia antigen and differences in host response. N Engl J Med 281: 571, 1969
Greenberg HB, Pollard RB, Lutwick LI, Gregory PB, Robinsin WS, Marigan TC: Human leukocyte interferon and hepatitis B virus infection. N Engl J Med 281: 571, 1969
Lopez C, Simmons RL, Mauer SM, Najarian JS, Good RA: Association of renal allograft rejection with virus infections. Am J Med 56: 280, 1974
Matas AJ, Simmons RL, Kjellstrand CM, Buselmeier TJ, Najarian JS: Increased incidence of malignancy during chronic renal failure. Lancet 1: 883, 1975
Slifkin RF, Goldberg J, Neff MS, Baez A, Mattoo N, Gupta S: Malignancy in end-stage renal disease. Trans Am Soc Artif Intern Organs 23: 34, 1977
Degaulet P. Reach I, Jacobs C: Cancer in patients on hemodialysis. N Engl J Med 300: 1279, 1979
Herr HW, Engen DE, Hostetier J: Malignancy in uremia: Dialysis versus transplantation. J Urol 121: 584, 1979
Hughsun MD, Hennigar GR, McManus JF: Atypical cysts, acquired renal cystic disease and renal cell tumors in end-stage dialysis kidneys. Lab Invest 42: 475, 1980
Comty CM, Cohen SL, Shapiro FL: Pericarditis in chronic uremia and its sequels. Ann Intern Med 75: 173, 1971.
Bailey Gl, Hampers CL, Hager EB, Merrill JP: Uremic pericarditis: Clinical features and management. Circulation 38: 582, 1968
Scrimshaw NS, Taylor CE, Gordon JE: Interactions of nutrition and infection. WHO Monogr Ser 57, 1978
Douglas SD, Schopfer K: Phagocyte function in protein- calorie malnutrition. Clin Exp Immunol 17: 121, 1974
Schopfer K, Douglas SD: Neutrophil function in children with kwashiorkor. J Lab Clin Med 88: 450, 1976
Guarnieri G, Ranieri F, Lipartiti T, Spangaro F, Giuntini D, Faccini L, Toigo G, Legnani F, Raimondi A, Campanacci L: Protein-calorie malnutrition in hemodialysis patients. Int J Artif Organs 3: 143, 1980
Comty CM, Wathen RL, Shapiro FL: Protein metabolism in renal failure. Urology 1: 528, 1973
Gulyassy PF, Aviram A, Peters JH: Evaluation of amino acid and protein requirements in chronic uremia. Arch Intern Med 126: 855, 1970
Aviram A, Peters JH, Gulyassy PF: Dialysance of amino acid and related substances. Nephron 8: 440, 1971
Dudrick SJ, MacFadyen BV, Van Buren CT, Ruberg RL, Maynard AT: Parenteral hyperalimentation: metabolic problems and solutions. Ann Surg 176: 259, 1972
Dudrick SJ, Rhoads JE: Total intravenous feeding, Sci Am 226: 73, 1972
Shils ME: Guidelines for total parenteral nutrition. JAMA 220: 1721, 1972
Abel RM, Beck CH Jr, Abbott WM, Ryan JA Jr, Barnett GO, Fischer JE: Improved survival from acute renal failure after treatment with intravenous essential 1-amino acids and glucose. N Engl J Med 288: 695, 1973
Robinson PJA, Rosen SM: Pyrexial reactions during hae- modialysis. Br Med J 1: 528, 1971
Raij L, Shapiro FL, Michael AF: Endotoxemia in febrile reactions during hemodialysis. Kidney Int 4: 57, 1973
Hindman SH, Favero MS, Carson LA, Peterson NJ, Schönberger LB, Solano JT: Pyrogenic reactions during haemodialysis caused by extramural enodotoxin. Lancet 2: 732, 1975
Siddiqui JY, Fitz AE, Lawton RL, Kirdendall WM: Causes of death in patients receiving long term hemodialysis. JAMA 212: 1350, 1970
Latos DL, Stone WJ, Alford RH: Staphylococcus aureus bacteremia in hemodialysis patients. J Dial 1: 399, 1977
Linnemann CC, McKee E, Laver MC: Staphylococcal infections in a hemodialysis unit. Am J Med Sci 276: 67, 1978
McGowan JE, Barnes MW, Finland M: Bacteremia at the Boston City Hospital. Occurrence and mortality during 12 selected years (1935–1972), with special reference to hospital-acquired cases. J Infect Dis 132: 316, 1975
Uman SJ, Johnson CE, Beirne GJ, Kunin CM: Pseudomonas aeruginosa bacteremia in a dialysis unit: I. Recognition of cases, epidemiologic studies and attempts at control. Am J Med 62: 667, 1977
Kuehnel EG: Outbreak of Pseudomonas cepacia bacteremia in a dialysis unit related to contaminated reused cells. Clin Res 23: 466A, 1975
Kirmani N, Tuazon CU, Murray HW, Parrish AE, Sheagren JN: Staphylococcus aureus carriage rate of patients receiving long-term hemodialysis. Arch Intern Med 138: 1657, 1978
Iannini PB, Crossley K: Therapy of staphylococcus aureus bacteremia associated with a removable focus of infection. Ann Intern Med 84: 558, 1976
Bennett WM, Muther RS, Parker RA, Feig P, Morrison G, Golper TA, Singer I: Drug therapy in renal failure: dosing guidelines for adults. Ann Intern Med 93: 62, 1980
Reidenberg MM, Drayer DE: Drug therapy in renal failure. Annu Rev Pharmacol Toxicol 20: 45, 1980
Goodwin NJ, Gastronouvo JJ, Friedman EA: Recurrent septic pulmonary embolization complicating maintenance hemodialysis. Ann Intern Med 71: 29, 1969
Levi J, Robson M, Rosenfeld JB: Septicaemia and pulmonary embolism complicating use of arteriovenous fistula in maintenance haemodialysis. Lancet 2: 288, 1970
Shapiro FL, Messner RP, Smith HT: Satellite hemodialysis. Ann Intern Med 69: 673, 1968
Ribot S, Rothfeld D, Frankel HJ: Infectious endocarditis in maintenance hemodialysis. Am J Med Sci, 264:183,
King LH Jr, Bradley KP, Shires DL Jr, Donohue JP, Glover JL: Bacterial endocarditis in chronic hemodialysis patients; a complication more common than previously suspected. Surgery 69: 554, 1971
Ribot S, Gilbert L, Rothfeld EL, Parsonnet V, Jacobs MG: Bacterial endocarditis with pulmonary edema necessitating mitral valve replacement in a hemodialysis-de- pendent patient. J Thorac Cardiovasc Surg 62: 59, 1971
Goodman JS, Crews HD, Ginn HE, Koenig MG: Bacterial endocarditis as a possible complication of chronic hemodialysis. N Engl J Med 280: 876, 1969
Leonard A, Raij L, Shapiro FL: Infective endocarditis and access site infections in patients on hemodialysis. Kidney Int 4: 407, 1973
Cross AD, Steigbigel RT: Infective endocarditis and access site infections in patients on hemodialysis. Medicine 55: 453, 1976
Leonard A, Comty CM, Shapiro FL, Raij L: Osteomyelitis in hemodialysis patients. Ann Intern Med 78:651,
Hochstein HD, Kirkham WR, Young VM: Recovery of more than one organism in septicemias. N Engl J Med 273: 468, 1965.
Hermans PE, Washington JA: Polymicrobial bacteremia. Ann Intern Med 73: 387, 1970
Bodey GP, Nies BA, Freireich EJ: Multiple organism septicemia in acute leukemia. Arch Intern Med 116:266,
McIntosh CS, Petrie JC, Macleod M: Maintenance of Silastic-Teflon shunts for intermittent haemodialysis. Br Med J 4: 717, 1969
Pendras JP, Smith MP: The Silastic-Teflon arterio-ve- nous cannula. Trans Am Soc Artif Intern Organs 12:222,
Haimov M: Vascular access for hemodialysis. Surg Gynecol Obstet 141: 619, 1975
Kopp KF, Grossman DF, Frey J: The care and maintenance of the Scribner Teflon-Silastic shunt. Experience how to prevent infection. Proc Eur Dial Transpl Assoc 4:373,
Brescia MJ, Cimino JE, Appel K, Hurwick BJ: Chronic hemodialysis, Using venipuncture anc(a surgically created arteriovenous fistula. N Engl J Med 275: 1089, 1966
Chinitz J, Yokoyama T, Bower R, Swartz C: Self sealing prosthesis for arteriovenous fistula in man. Trans Am Soc Artif Intern Organs 18: 452, 1972
Zerbino VR, Rice DA, Katz LA, Nidus BD: A six year clinical experience with arteriovenous fistulas and bypasses for hemodialysis. Surgery 76: 1018, 1974
Lytton B, Goffinet JA, May CJ, Weiss RM: Experience with arteriovenous fistula in chronic hemodialysis. J Urol 104: 512, 1967
Faris TD, Carey TA: Arteriovenous shunts for hemodialysis. Am J Surg 114: 679, 1967
Byrne JP, Stevens LE, Weaver DH, Maxwell JG, Reemtsma K: Advantages of surgical arteriovenous fistulas for hemodialysis. Arch Surg 102: 359, 1971
Ralston AJ, Harlow GR, Jones DM, Davis P: Infections of Scribner and Brescia arteriovenous shunts. Br Med J 3: 408, 1971
Haimov M, Baez A, Neff M, Slifkin R: Complications of arteriovenous fistulas for hemodialysis. Arch Surg 110: 708, 1975
VanderWerf BA, Rarrazzi LC, Katzman HA, Schild AF: Three year experience with bovine graft arteriovenous (A-V) fistulas in 100 patients. Trans Am Soc Artif Intern Organs 21: 296, 1975
Merickel JH, Andersen RC, Knutson R, Lipschultz ML, Hitchcock CR: Bovine carotid artery shunts in vascular access surgery. Complications in the chronic hemodialysis patient. Arch Surg 109: 245, 1974
Biggers JA, Remmers AR Jr, Glassford DM, Lindley JD, Sarles HE, Fish JC: Bovine graft fistulas in patients with vascular access problems receiving hemodialysis. Surgery 140: 690, 1975
Yokoyama T, Bower R, Chinitz J, Schwartz A, Swartz C: Experience with 100 bovine arteriografts for maintenance hemodialysis. Trans Am Soc Artif Intern Organs 20: 328, 1974
Kinnaert P, Vereerstraeten PJC, Toussaint CV and Gertruyden J: Nine years experience with internal arteriovenous fistulas for haemodialysis: A study of some factors influencing the results. Br J Surg 64: 242, 1977
Mennes PA, Gilula LA, Anderson CB, Etheredge EE, Weerts C, Harter H: Complications associated with arteriovenous fistulas in patients undergoing chronic hemodialysis. Arch Intern Med 138: 1117, 1978
Butler HG, Baker LD, Johnson JM: Vascular access for chronic hemodialysis: Polytetrafluoroethylene (PTFE) versus bovine heterograft. Am J Surg 134: 791, 1977
Wellington JL: Expanded polytetrafluoroethylene prosthetic grafts for blood access in patients on dialysis. Can J Surg 21: 420, 1978
Gross GF, Hayes JF: PTFE graft arteriovenous fistulae for hemodialysis access. Am Surg 45: 748, 1979
Bhat DJ, Tellis VA, Kohlberg WI, Driscoll B, Veith FJ: Management of sepsis involving expanded polytetrafluoroethylene grafts for hemodialysis access. Surgery 87: 445, 1980
Lilly L, Nghiem D, Mendez Picon G, Lee HM: Comparison between bovine heterograft and expanded PTFE grafts for dialysis access. Am J Surg 46: 694, 1980
Kaslow RA, Zellner SR: Infection in patient on maintenance haemodialysis. Lancet 2: 117, 1972
Martin AM, Clunie GJA, Tonkin RW, Robson JS: The aetiology and management of shunt infections in patients on intermittent haemodialysis. Proc Eur Dial Transpl Assoc 4: 67, 1967
Dathan JR, Frankel RJ, Goodwin FJ, Marsh FP, Murray M, Thompson JM, Youngs GR: One year experience in a Ministry of Health dialysis centre. Br Med J 2: 102, 1970
Morris AJ, Bilinsky RT: Prevention of staphylococcal shunt infections by continuous vancomycin prophylaxis. Am J Med Sci 261: 88, 1971
Johanson WG, Pierce AK, Sanford JP: Changing pharyngeal bacterial flora of hospitalized patients. N Engl J Med 281: 1137, 1969
Rackow EC, Fein I A, Sprung C, Groodman Rs: Uremic pulmonary edema. Am J Med 64: 1084, 1978
Hopps HC, Wissler RW: Uremic pneumonitis. Am J Pathol 31: 261, 1955.
Jadav DK, Sant SM, Acharya VN: Bacteriology of urinary tract infection in patients of renal failure undergoing dialysis. J Postgrad Med 23: 10, 1977
Sweet R, Keane WF: Perinephric abscess in patients with polycystic kidney disease undergoing chronic hemodialysis. Nephron 23: 237, 1979
Onorato IM, Axelrod JL, Lorch JA, Brensilver JM, Bokkenheuser V. Fungal infections of dialysis fistulae. Ann Intern Med 91: 50, 1979
Pradhan RP, Katz LA, Nidus BD, Matalon R, Eisinger RP: Tuberculosis in dialyzed patients. JAMA 229: 798, 1974
Papadimitriou M, Mimmos D, Metaxas P: Tuberculosis in patients on regular haemodialysis. Nephron 24: 53, 1979
Andrew OT, Schoenfeld P, Hopewell PC, Humphreys M: Tuberculosis in patients with end-stage renal disease. Am J Med 68: 59, 1980
Lundin AP, Adler AJ, Berlyne GM, Friedman EA: Tuberculosis in patients undergoing maintenance hemodialysis. Am J Med 67: 597, 1979
Rutsky EA, Rostand SG: Mycobacteriosis in patients with chronic renal failure. Arch Intern Med 140: 57, 1980
Sasaki S, Akiba T, Suenaga M, Tomura S, Yoshiyama N, Nakagawa S, Shoji T, Sasaoka T, Takeuchi J: Ten Years survey of dialysis associated tuberculosis. Nephron 24: 141, 1979
Betts RF, Hanshaw JB: Cytomegalovirus in the compromised host. Annu Rev Med 28: 103, 1977
Luby JP, Ramirz-Ronda C, Pinner S, Hull A, Vergne-Marini P: A longitudinal study of varicella-zoster virus infections in renal transplant recipients. J Infect Dis 135: 659, 1977
Swuwansirikul S, Rao N, Dowling JN, Ho M: Primary and secondary cytomegalovirus infection. Arch Intern Med 137: 1026, 1977
Chatterjee SN, Jordan GW: Prospective study of the prevalence and symptomatology of cytomegalovirus infection in renal transplant recipients. Transplantation 28: 457, 1979
Betts RF, Cestero RV, Freeman RB, Douglas RG: Epidemiology of cytomegalovirus infection in end-stage renal disease. J Med Virol 4: 89, 1979
Sexton DJ, Smith EW, Gutman RA, Helms MJ, Lang DJ: Cytomegalovirus infection and chronic hemodialysis. Clin Nephrol 11: 3, 1979
Pass RF, Long WF, Whitley RJ, Sooney SJ, Diethelm AG, Reynolds DW, Alford CA: Productive infection with cytomegalovirus and herpes simplex virus in renal transplant recipients. Role of source of kidney. J Infect Dis 137: 556, 1978
Betts RJ, Freeman RB, Douglas RG, Talley TE, Rundell B: Transmission of cytomegalovirus infection with renal allograft. Kidney Int 7: 385, 1975
Anderson RJ, Schafer LA, Olin DB, Eickhoff TC: Infectious risk factors in the immunosuppressed host. Am J Med 54: 452, 1973
Myerowitz RL, Medeiros AA, O’Brien TF: Bacterial infection in renal homotransplant recipients. Am J Med 53: 308, 1972
Eickhoff TC, Olin DB, Anderson RJ, Schafer LA: Current problems and approaches to diagnosis of infection in renal transplant recipients. Transplant Proc 4: 693, 1972
Burgos-Calderon R, Pankey GA, Figueroa JE: Infection in kidney transplantation. Surgery 70: 334, 1971
Ahern MJ, Comite H, Andriole VT: Infectious complication associated with renal transplantation: An analysis of risk factors. Yale J Biol Med 51: 513, 1978
Rifkind D, Marchioro TL, Schneck SA, Hill RB Jr: Systemic fungal infections complicating renal transplantation and immunosuppressive therapy. Am J Med 43: 28, 1967
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Keane, W.F., Raij, L.R. (1983). Host Defenses and Infectious Complications in Maintenance Hemodialysis Patients. In: Drukker, W., Parsons, F.M., Maher, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6768-7_33
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