Summary
Workers vary in susceptibilities to specific toxic agents as a consequence of individual variations in work practices, personal habits, predisposing conditions, and genetic factors. In order to safeguard workers’ health, ambient monitoring of toxic agents must oftimes be supplemented by biological monitoring. To illustrate the current status of biological monitoring of toxic inorganic agents, carbon monoxide and cadmium are discussed as reference hazards in the workplace. Attention is focused particularly upon (a) selection, standardisation, and interlaboratory comparison comparison of analytical procedures, (b) applications of noninvasive instrumental techniques to estimate body burdens, (c) diagnostic tests for organ-specific toxicity, and (d) problems in interpretations of analytical results owing to confounding factors such as cigarette smoking and mixed exposures to toxic agents. In the multidisciplinary approach to protection of workers’ health, clinical pathologists play an important role by developing and supervising biological monitoring procedures and by helping to interpret the analytical results.
Supported by Grant No. ES-01337 from the National Institute of Environmental Health Sciences and Grant No. EV-03140 from the US Department of Energy.
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Sunderman, W. (1984). Current Use of Ambient and Biological Monitoring: Reference Workplace Hazards. Inorganic Toxic Agents — Discussion of Carbon Monoxide and Cadmium. In: Berlin, A., Yodaiken, R.E., Henman, B.A. (eds) Assessment of Toxic Agents at the Workplace. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6762-5_15
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DOI: https://doi.org/10.1007/978-94-009-6762-5_15
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