Abstract
The existence of a brain renin-angiotensin system (RAS)1 was originally proposed in 1971 [1–4] on the basis of the discovery of the components required for the formation of angiotensin II (ANG II) in the brain. At that time, none of the individual components of this complex enzyme peptide system had been obtained in pure form, and their physiochemical properties were still unclear.
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Ganten, D., Printz, M., Unger, T., Lang, R.E. (1984). The Brain Renin-Angiotensin System: Problems and Answers. In: Villarreal, H., Sambhi, M.P. (eds) Topics in Pathophysiology of Hypertension. Developments in Cardiovascular Medicine, vol 30. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6741-0_39
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DOI: https://doi.org/10.1007/978-94-009-6741-0_39
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