Abstract
The contribution of renin substrate to the in vivo rate of angiotensin I production has recently gained further significance with the determination of the kinetic parameters of the renin reaction [1, 2]. Under normal physiological conditions, the concentration of renin substrate has been shown to represent a rate-limiting step for the renin reaction in vivo [2, 3]. The postulate that altered forms of renin substrate may also contribute to elevated blood pressure has led to a closer examination of the physical and chemical nature of these proteins.
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References
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© 1984 Martinus Nijhoff Publishers, Boston
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Eggena, P., Barrett, J.D., Shionoiri, H., Sambhi, M.P. (1984). Enzymatic Studies with Renin Substrate. In: Villarreal, H., Sambhi, M.P. (eds) Topics in Pathophysiology of Hypertension. Developments in Cardiovascular Medicine, vol 30. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6741-0_38
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DOI: https://doi.org/10.1007/978-94-009-6741-0_38
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