Abstract
For decades, our group has been engaged in studies of central, reflex, and peripheral nervous influences on cardiovascular function, mainly because they reflect by far the most differentiated, powerful, and swift of all control systems involved [1–3]. For example, at the limbic-hypothalamic level, nervous and hormonal mechanisms are linked together to form highly specific psychoemotional response patterns, each elicited by the appropriate type of environmental stimuli and, in their actions, often overswaying the reflex control level [3].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Folkow B: Nervous control of the blood vessels. Physiol Rev 35:629–663, 1955.
Folkow B: Range of control of the cardiovascular system by the central nervous system. Physiol Rev 40:93–99, 1966.
Folkow B: Relevance of cardiovascular reflexes. Invited lecture, in Hainsworth R, Kidd C, Linden RJ (editors): Cardiac Receptors. New York, Cambridge University Press, 1979, pp 473–505.
Okamoto K: Spontaneous hypertension in rats. Internat Rev Exp Pathol 7:227–270, 1969.
Julius S, Esler M (editors): The Nervous System in Arterial Hypertension. Springfield, III, Charles C Thomas Publisher, 1976.
Folkow B: Central neuro-hormonal mechanisms in spontaneously hypertensive rats as compared with human essential hypertension. Clin Sci Mol Med 48:205s–214s, 1975.
Frohlich ED, Pfeffer MA: Adrenergic mechanisms in human hypertension and in spontaneously hypertensive rats. Clin Sci Mol Med 48:225s–238s, 1975.
Hallback M, Folkow B: Cardiovascular responses to acute mental stress in spontaneously hypertensive rats. Acta Physiol Scand 90:684–698, 1974.
Hallback M: Consequence of social isolation on blood pressure, cardiovascular reactivity and design in spontaneously hypertensive rats. Acta Physiol Scand 93:455–465, 1975.
Yamori Y: Neurogenic mechanisms of spontaneous hypertension, in Onesti C, Fernandes M, Kim KK (editors): Regulation of Blood Pressure by the Central Nervous System. New York, Grune & Stratton, 1976, p 65.
Falkner B, Onesti G, Angelakos ET, et al.: Cardiovascular response to mental stress in normal adolescents with hypertensive parents. Hypertension 1:23–30, 1979.
Falkner B: Cardiovascular responses to stress in adolescents, in Onesti G, Kim KE (editors): Phasic Pressor Mechanisms: Hypertension in the Young and the Old. Sixth Hahnemann International Symposium on Hypertensive Disease. New York, Grune & Stratton, 1981.
Folkow B, Neil E: Circulation. New York, Oxford University Press, 1971.
Lundin S, Thoren P: Renal function and sympathetic activity during ‘mental stress’ in normotensive and spontaneously hypertensive rats. Acta Physiol Scand 1982.
Axelrod J: Experimental hypertension and noradrenergic nerves, in Davies DS, Reid JR (editors): Central Action of Drugs in Blood Pressure Regulation. London, Whitefriars Press Ltd, 1975, pp 1–7.
Champlain J De, Krakoff LR, Axelrod J: Interrelationships of sodium intake, hypertension and norepinephrine storage in the rat. Circ Res 24(Suppl I):75–92, 1969.
Takeshita A, Mark AL: Neurogenic contribution to hindquarter vasoconstriction during high sodium intake in Dahl strain of genetically hypertensive rat. Circ Res 43(Suppl I):86–91, 1978.
Tobian L, Lange J, Iwai J, et al.: Prevention with thiazide of NaCl-induced hypertension in Dahl’ s’ rats. Hypertension 1:316–323, 1979.
Mulvany MJ, Halpern W: Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41:19–26, 1977.
Nilsson H, Folkow B: Different nerve responses in elastic and muscular arteries. Acta Physiol Scand 1982.
Folkow B: Cardiovascular structural adaptation: Its role in the initiation and maintenance of primary hypertension. The Fourth Volhard Lecture. Clin Sci Mol Med 55:3s–22s, 1978.
Johsnsson B, Johansson SR, Ljung B, et al.: A receptor kinetic model of a vascular neuroeffector. J Pharmacol Exp Ther 180(3):637–646, 1972.
Mulvany MJ, Hansen PK, Aalkjaer C: Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrower lumen, a thicker media and a larger number of smooth muscle cell layers. Circ Res 43:854–864, 1978.
Mulvany MJ, Aalkjaer C, Christensen J: Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats. Hypertension 2:664–671, 1980.
Collis MG, De Mey D, Vanhoutte PM: Renal vascular reactivity in the young spontaneously hypertensive rat. Hypertension 2:45–52, 1980.
Lais LT, Shaffer RA, Brody MJ: Neurogenic and humoral factors controlling vascular resistance in the spontaneously hypertensive rat. Circ Res 35:764–774, 1974.
Folkow B, Sonnenschein RR, Wright DL: Loci of neurogenic and metabolic effects on precapillary vessels of skeletal muscle. Acta Physiol Scand 81:459–471, 1971.
Lundgren Y, Hallback M, Weiss L, et al.: Rate and extent of adaptive cardiovascular changes in rats during experimental renal hypertension. Acta Physiol Scand 91:103–115, 1974.
Hallback-Nordlander M, Noresson E, Lundgren Y: Haemodynamic alterations after reversal of renal hypertension in rats. Clin Sci 57:15s–17s, 1979.
Muirhead EE: Antihypertensive functions of the kidney. Arthur C. Corcoran Memorial Lecture. Hypertension 2:444–464, 1980.
Muirhead EE, Pitcock JA: Evidence for an invovement of the renal papilla in hypertension, in Mandal AK, Bohman SO (editors): The Renal Papilla and Hypertension. New York, Plenum Press, 1980, pp 35–61.
Gothberg G, Lundin S, Folkow B: Acute vasodepressor effect in normotensive rats following extracorporal perfusion of the declipped kidney of two-kidney, one-clip hypertensive rats. Hypertension 1982.
Gothberg G, Lundin S, Folkow B, et al.: Is the antihypertensive function of the kidney elicited by renomedullary depressor substances partly acting on the central nervous system? Acta Med Scand 1982 (abstract).
Buckley JP, Ferrario CM: Central Actions of Angiotensin and Related Hormones. New York, Pergamon Press, 1977.
Thoren P: Characteristics and reflex effects of aortic baroreceptors with non-medullated afferents in rabbits and rat, in Kovach AGP, Sandor P, Kollai M (editors): Advancements in Physiological Sciences. Proceedings of the 28th International Congress of Physiological Sciences. New York, Pergamon Press, 1980, vol 9, pp 85–94.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Martinus Nijhoff Publishers, Boston
About this chapter
Cite this chapter
Thorén, P., Göthberg, G., Lundin, S., Nilsson, H., Folkow, B. (1984). Some Aspects of Cardiovascular Nervous Control in Spontaneously Hypertensive Rats: Central and Peripheral Mechanisms. In: Villarreal, H., Sambhi, M.P. (eds) Topics in Pathophysiology of Hypertension. Developments in Cardiovascular Medicine, vol 30. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6741-0_28
Download citation
DOI: https://doi.org/10.1007/978-94-009-6741-0_28
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-009-6743-4
Online ISBN: 978-94-009-6741-0
eBook Packages: Springer Book Archive