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Endoscopic and Pharmacologic Therapy of Upper Gastrointestinal Bleeding’. Laser vs. Pharmacotherapy vs. Autacid

  • Chapter
Therapeutic Laser Endoscopy in Gastrointestinal Disease

Part of the book series: Developments in Gastroenterology ((DIGA,volume 4))

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Abstract

Upper gastrointestinal bleeding remains a major clinical problem in medicine with an estimated hospital admission rate of 50–150 per 100,000 population for actue upper gastrointestinal bleeding (1, 2). In 1983 it is a sobering fact that there is not always an effective therapeutic modality for upper gastrointestinal bleeding. The treatment is still fraught with futility. The mortality has remained between 10–15% for 40 years, despite advances in resuscitation and in the care of critically ill patients in intensive care units; and despite the ready availability of fiberoptic endoscopy, a modality which many thought would improve treatment and prognosis by early specific diagnosis. Finally, with the advent of effective anti-secretory histamine H2 receptor antagonists it has been hoped that there would be a significant reduction in morbidity and mortality in upper gastrointestinal bleeding. However, neither cimetidine or other currently available antisecretory drugs effectively control upper gastrointestinal bleeding. (23) The principles in management of upper gastrointestinal bleeding should continue to be a team approach, covering:

  1. 1.

    Resuscitation

  2. 2.

    Specific diagnosis (endoscopy, radionuclide Tc99, angiography)

  3. 3.

    Specific effective therapy.

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Authors
  1. P. Bright-Asare
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Editor information

Editors and Affiliations

  1. Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, 44106, USA

    David Fleischer MD

  2. Division of Gastroenterology Wadsworth Veterans Administration Medical Center, UCLA School of Medicine, Los Angeles, CA, 90024, USA

    Dennis Jensen MD

  3. Charles R. Drew Postgraduate Medical School, Los Angeles, CA, 90059, USA

    Peter Bright-Asare MD (Associate Dean of Research) (Associate Dean of Research)

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© 1983 Martinus Nijhoff Publishers, Boston

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Bright-Asare, P. (1983). Endoscopic and Pharmacologic Therapy of Upper Gastrointestinal Bleeding’. Laser vs. Pharmacotherapy vs. Autacid. In: Fleischer, D., Jensen, D., Bright-Asare, P. (eds) Therapeutic Laser Endoscopy in Gastrointestinal Disease. Developments in Gastroenterology, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6723-6_5

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  • DOI: https://doi.org/10.1007/978-94-009-6723-6_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6725-0

  • Online ISBN: 978-94-009-6723-6

  • eBook Packages: Springer Book Archive

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