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Endemic Non-Toxic Goiter

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X-ray fluorescent scanning of the thyroid

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 3))

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Abstract

A non-toxic goiter is defined as an enlargement of the thyroid gland which is not due to thyroiditis or malignancy, maintaining an euthyroid hormone status (41).

This work was supported by the Deutsche Forschungsgemeinschaft.

The cooperation of Prof. C.R.Pickardt,M.D., and R.Kantlehner,Ph.D. and the technical assistance of Mrs. L.Segnitz and Mrs. H.Colling are gratefully acknowledged.

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References

  1. Abrams G, Larsen P. 1973. Triiodothyronine and thyroxine in the serum and thyroid gland of iodine deficiency rats. J.Clin.Invest. 52:2522.

    Article  PubMed  CAS  Google Scholar 

  2. Aubert B, Fragu P, Di Paola M, Rougier P, Tubiana M. 1981. Application of x-ray fluorescence to the study of iodine distribution and content in the thyroid. Eur.J.Nucl.Med. 6:407.

    Article  PubMed  CAS  Google Scholar 

  3. Beckers C, Cornette C. 1971. TSH-production rate in non-toxic goiter. J.Clin.Endocrinol.Metab. 32:852.

    Article  PubMed  CAS  Google Scholar 

  4. Berson S, Yalow R. 1954. Quantitative aspects of iodine metabolism. J.Clin.Invest. 33:1533.

    Article  PubMed  CAS  Google Scholar 

  5. Berthier C, Lemarchand-Béraud T. 1978. Importance of thyroid iodine and cyclic AMP, and TSH concentrations on goiter formation in rats. Acta endocrinol. 89:567.

    PubMed  CAS  Google Scholar 

  6. LeBlanc A, Bell R, Johnson Ph. 1973. Measurement of I-concentration in thyroid tissue by x-ray fluorescence. J.Nucl.Med. 14:816.

    PubMed  CAS  Google Scholar 

  7. Boddy K, Harden R, Alexander W. 1968. In vivo measurement of the intrathyroidal iodine concentration in man by activation analysis. J.Clin.Endocrinol.Metab. 28:294.

    Article  PubMed  CAS  Google Scholar 

  8. Bray G. 1968. Increased sensitivity of the thyroid in iodine-depleted rats to the goitrogenic effects of thyrotropin. J.Clin.Invest. 47:1640.

    Article  PubMed  CAS  Google Scholar 

  9. Chopra K, Hershman J, Hornabrook R. 1975. Serum thyroid hormone and thyrotropin levels in subjects from endemic goiter regions of New Guinea. J.Clin.Endocrinol.Metab. 40:326.

    Article  PubMed  CAS  Google Scholar 

  10. Coble Y, Kohler P. 1970. Plasma TSH levels in endemic goiter subjects. J.Clin.Endocrinol. 31:220.

    Article  CAS  Google Scholar 

  11. Costa A, Cottino F. 1963. Research on iodine meatbolism in endemic goiter in Piedmont. Metabolism 12:35.

    PubMed  CAS  Google Scholar 

  12. Delange F, Camus M, Ermans A. 1972. Circulating thyroid hormones in endemic goiter. J.Clin.Endocrin. 34:891.

    Article  CAS  Google Scholar 

  13. Dige-Petersen H, Hummer L. 1977. Serum thyrotropin concentrations under basal conditions and after stimulation with thyrotropin releasing hormone in idiopathic non-toxic goiter. J.Clin.Endocrinol.Metab. 44:1115.

    Article  PubMed  CAS  Google Scholar 

  14. Dunn J, Medeiros-Neto G. 1974. Endemic goiter and cretinism: continuing threats to the world health. Pan American Health Organization WHO. Scientific Publication No 292.

    Google Scholar 

  15. Ermans A. 1978. Disorders of iodine deficiency: endemic goiter. in: Ingbar SH, Werner SC (eds). The Thyroid. 4th ed. Hagerstown, Harper and Row.

    Google Scholar 

  16. Ermans AM, Verelst J. 1980. Acute effects of supra-physiological doses of iodide in the human being: management of non-toxic goiter. J.Mol.Med. 4:199.

    Google Scholar 

  17. Ermans AM, Kinthaert J, Delcroix C, Collard J. 1968. Metabolism of intrathyroidal iodine in normal man. J.Clin.Endocrinol.Metab. 28:169.

    Article  PubMed  CAS  Google Scholar 

  18. Fisher DA, Sack J, Oddie TH, Pekary AE, Hershman JM, Lam RW, Parslow ME. 1977. Serum T4, TBG, T3 uptake, T3, reverse T3, and TSH concentrations in children 1 to 15 years of age. J.Clin.Endocrinol.Metab. 45:191.

    Article  PubMed  CAS  Google Scholar 

  19. Foley TP, Owings J, Hayford JH, Blizzard RM. 1972. TSH responses to TRH in children. J.Clin.Invest. 51:431.

    Article  PubMed  Google Scholar 

  20. McGarack TH, Seegers U. 1959. Status of the thyroid gland after age 50. Metabolism 8:136.

    Google Scholar 

  21. Garcia-Bulnes G, Cervantes C, Cerbon MA, Tudon H. 1977. Serum thyrotropin, triiodothyronine, and thyroxine levels by radioimmunoassay during childhood and adolescence. Acta endocrinol. 86:742.

    PubMed  CAS  Google Scholar 

  22. Gerber D. 1980. Schilddrüsengewichte und Jodsalzprophylaxe. Schweiz.Med.Wschr. 110:2010.

    PubMed  CAS  Google Scholar 

  23. Golstein-Golaire J, Delange F. 1971. Serum thyrotropin level during growth in man. Europ.J.Clin.Invest. 1:405.

    Article  PubMed  CAS  Google Scholar 

  24. Greer MA. 1962. The natural occurrence of goitrogenic agents. Rec.Adv.Horm.Res. 18:187.

    CAS  Google Scholar 

  25. Habermann J, Heinze HG, Horn K, Kantlehner R, Marschner I, Neumann J. Alimentärer Jodmangel in der Bundesrepublik. Dtsch.med.Wschr. 100:1937.

    Google Scholar 

  26. Heedman PA, Jacobson B. 1964. Thyroid iodine determined by x-ray spectrophotometry. J.Clin.Endocrin. 24:246.

    Article  CAS  Google Scholar 

  27. Heidemann P, Stubbe P. 1978. Serum 3,5,3′-triiodothyronine, thyroxine, and thyrotropin in hypothyroid infants with congenital goiter and the response to iodine. J.Clin. Endocrinol.Metab. 47:189.

    Article  PubMed  CAS  Google Scholar 

  28. Hellstern P, Keller HE, Weinheimer B, Wesch H. 1978. Thyroid iodine concentration and total thyroid iodine in normal subjects and in endemic goiter subjects. Clin.Endocrinol. 9:351.

    Article  CAS  Google Scholar 

  29. Hoffer PB, Jones WB, Crawford RB, Beck R, Gottschalk A. 1968. Fluorescent thyroid scanning: a new method of imaging the thyroid. Radiology 90:342.

    Google Scholar 

  30. Horn K. 1976. Trijodthyronin (T3): Zur Bestimmung und pathophysiologischen Bedeutung. München, Urban u. Schwarzenberg.

    Google Scholar 

  31. Igl W, Seiderer M, Fink U, Lissner J. 1980. Quantitative Volumenbestimmung der Schilddrüse mit Hilfe der Sonographie. Nuc Compact 1:11.

    Google Scholar 

  32. Igl W, Lukas P, Leisner B, Fink U, Seiderer M, Pickardt CR. 1981. Sonographische Volumenbestimmung der Schilddrüse. Vergleich mit anderen Methoden. Nuklearmedizin 20:64.

    PubMed  CAS  Google Scholar 

  33. Imamura K, Sasaki Y, Sekita N, Someya K, Fuji M. 1979. Quantitative in vivo measurement of thyroidal iodine content by static x-ray fluorescent technique: some preliminary clinical observations. Invest.Radiol. 14:316.

    Article  PubMed  CAS  Google Scholar 

  34. Ingbar SH. 1972. Autoregulation of the thyroid. Response to iodide excess and depletion. Mayo Clin.Proc. 47:814.

    PubMed  CAS  Google Scholar 

  35. Inoue K, Taurog A. 1968. Acute and chronic effects of iodide on thyroid radioiodine metabolism in iodine-deficient rats. Endocrinology 83:279.

    Article  PubMed  CAS  Google Scholar 

  36. Jackson D, Vanderschueren-Lodeweyckx M, Grant DB. 1975. Thyrotrophin estimation in diagnosis and treatment of childhood thyroid disorders. Arch.Dis.Childhood 50:522.

    Article  CAS  Google Scholar 

  37. Jacobson B. 1964. X-ray spectrophotometry in vivo. Am.J.Roentgenol. 91:202.

    CAS  Google Scholar 

  38. Jonckheer M, Deconinck F. 1979. Dissociation between iodine-storage function and hormone formation, as observed with XRF-scanning of the thyroid. Ann.Endocrin. 40:45A.

    Google Scholar 

  39. Jonckheer MH, Vanhaelst L, Deconinck F, Michotte Y. 1981. Atrophic autoimmune thyroiditis: relationship between the clinical state and intrathyroidal iodine as measured in vivo in man. J.Clin.Endocrinol.Metab. 53:476.

    Article  PubMed  CAS  Google Scholar 

  40. Kantlehner R, Leisner B, Heinze HG, Lissner J. 1979. Untersuchung des Jodgehalts der Schilddrüse durch Fluoreszenzanregung. Fortschr.Röntgenstr. 130:597.

    Article  CAS  Google Scholar 

  41. Klein E, Kracht J, Krüskemper HL, Reinwein D, Scriba PC. 1973. Klassifikation der Schilddrüsenkrankheiten. Dtsch.med.Wschr. 98:2249.

    Article  PubMed  CAS  Google Scholar 

  42. Kohler H, Studer H. 1981. Biochemische Veränderungen in “warmen” und “kalten” Strumaknoten. Therapiewoche 31:1539.

    Google Scholar 

  43. Koutras DA, Alexander WD, Harden RM, Wayne E. 1964. Effect of small iodine supplements on thyroid function in normal individuals. J.Clin.Endocrinol.Metab. 24:857.

    Article  PubMed  CAS  Google Scholar 

  44. Leisner B, Kantlehner R, Heinze HG, Lissner J. 1979. Klinische Ergebnisse der Schilddrüsenszintigraphie und Jodbestimmung mit Fluoreszenztechnik. Fortschr.Röntgenstr. 130:694.

    Article  CAS  Google Scholar 

  45. Leisner B, Pickardt CR, Fink U, zur Nieden J, Igl W. 1982. Bestimmung des Schilddrüsenvolumens mittels kleinrechnerunterstützter Sonogrammauswertung nach verschiedenen Therapiemaßnahmen. in: Nuklearmedizin. HAE Schmidt, H Rösler (eds). Stuttgart-New York, Schattauer, p. 757.

    Google Scholar 

  46. Meignan M, Galle P. 1978. Exploration thyroidienne par fluorescence X. Etude réalisée chez 140 malades. Nouv. Presse Med. 7:13.

    PubMed  CAS  Google Scholar 

  47. Nagataki S, Ingbar SH. 1963. Demonstration of a second thyroidal iodide pool in rat thyroid glands by double isotope labeling. Endocrinology 73:479.

    Article  PubMed  CAS  Google Scholar 

  48. Nodine JH, Channick BJ, Sokhos D, Tassoni SD, Perloff WH. 1957. Measurement of the active iodine stores and daily hormonal output of the intact human thyroid. J.Clin. Endocrin. 17:832.

    Article  CAS  Google Scholar 

  49. Palmer DW, Deconinck F, Swann SJ, Okerlund M, Kaufman L, Hoffer PB. 1976. Low cost intrathyroidal iodine quantification with a fluorescent scanner. Radiology 119:733.

    PubMed  CAS  Google Scholar 

  50. Patel YC, Pharoah POD, Hornabrook RW, Hetzel BS. 1973. Serum triiodothyronine, thyroxine and thyroid-stimulating hormone in endemic goiter: a comparison of goitrous and nongoitrous subjects in New Guinea. J.Clin.Endocrinol.Metab. 37:783.

    Article  PubMed  CAS  Google Scholar 

  51. Patton JA, Hollifield J, Lee GS, Brill AB. 1974. Quantitative scanning of thyroidal iodine pools for assessment of thyroid disease. J.Nucl.Med. 15:522.

    Google Scholar 

  52. Petersen F. 1978. Altersabhängige Änderungen im Regelkreis der Schilddrüse. Therapiewoche: 961.

    Google Scholar 

  53. Pickardt CR, Erhardt F, Grüner J, Horn K, Scriba PC. 1972. Stimulation der TSH-Sekretion durch TSH bei blander Struma: Diagnostische Bedeutung und pathophysiologische Folgeerscheinungen. Klin.Wschr. 50:1134.

    Article  PubMed  CAS  Google Scholar 

  54. Rapoport B, West MN, Ingbar SH. 1976. On the mechanism of inhibition by iodine of the thyroid adenylate cyclase response to thyrotropic hormone. Endocrinology 99:11.

    Article  PubMed  CAS  Google Scholar 

  55. Rasmussen SN, Hjorth L. 1974. Determination of thyroid volume by ultrasonic scanning. J.Clin.Ultrasound 2:143.

    Article  PubMed  CAS  Google Scholar 

  56. Reinwein D, Durrer HA, Meinhold H. 1981. Iodine, thyroxine (T4), triiodothyronine(T3 ) , 3′,3,5′-triiodothyronine (rT3), 3,3′-diiodothyronine (T2) in normal human thyroids. Effect of excessive iodine exposure. Horm.Metab.Res. 13:456.

    Article  PubMed  CAS  Google Scholar 

  57. Ridder-Dirks A. 1979. Vergleichende Untersuchungen zur medikamentösen Therapie der euthyreoten Struma. Thesis Göttingen.

    Google Scholar 

  58. Riek M, Kohler H, König MP, Bürgi H, Studer H. 1974. Zur Pathogenese des Knotenkropfes. Therapiewoche 24:2332.

    Google Scholar 

  59. Robertson I, Boddy K, Hooper MJ, Stevenson RD, McGhie T, Alexander WD, Wilson GM. 1976. Total thyroidal content of iodine in thyrotoxic patients measured by in-vivo neutron activation analysis. Clin. Endocrin. 5:151.

    Article  CAS  Google Scholar 

  60. Schneider PB. 1964. Thyroidal iodine heterogeneity: “last come, first served” system of iodine turnover. Endocrinology 74:973.

    Article  PubMed  CAS  Google Scholar 

  61. Scriba PC, Pickardt CR. 1980. Die blande Struma. In: Die Krankheiten der Schilddrüse. K Oberdisse, E Klein, D Reinwein (eds) 2nd ed. Stuttgart-New York, G.Thieme p. 493.

    Google Scholar 

  62. Steiner H, Zimmermann G. 1978. Die Epidemiologie der endemischen Struma unter Jodsalzprophylaxe. Wien.med.Wschr. 4:476.

    Google Scholar 

  63. Studer H, Kohler H, Bürgi H. 1974. Iodine deficiency. In: Endocrinology vol.III: Thyroid. MA Greer, DH Solomon (eds) Washington DC, Am.Physiol. Soc.

    Google Scholar 

  64. Tadros TG, Maisey MN, Tang Fui SC, Turner PC. 1981. The iodine concentration in benign and malignant thyroid nodules measured by x-ray fluorescence. Brit.J.Radiol. 54:626

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. B. Leisner
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Editors and Affiliations

  1. Department of Radioisotopes Academic Hospital, Vrije Universiteit, Brussel, Belgium

    M. H. Jonckheer MD, PhD  & F. Deconinck PhD  & 

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© 1983 Martinus Nijhoff Publishers, Boston

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Leisner, B. (1983). Endemic Non-Toxic Goiter. In: Jonckheer, M.H., Deconinck, F. (eds) X-ray fluorescent scanning of the thyroid. Developments in Nuclear Medicine, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6705-2_8

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  • DOI: https://doi.org/10.1007/978-94-009-6705-2_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6707-6

  • Online ISBN: 978-94-009-6705-2

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