Pharmacological approach of drugs used in coronary insufficiency and cerebrovascular pathology

Abstract

The choice of animal models in vascular diseases is as difficult as that of atherogenic diets (see Appendix). Atherosclerosis may be considered as the main cause of coronary insufficiency due to a progressive reduction of the internal size of the epicardial coronary arteries. Spasm of a coronary artery is also involved in more than one third of coronary insufficiencies. The resulting desequilibrium between oxygen supply and oxygen demand of the myocardium of a hypoperfused area acts as a trigger for haemodynamic, metabolic and electric disturbances.