In Situ Lobular Carcinoma

  • Rosemary R. Millis
Part of the Current Histopathology book series (CUHI, volume 7)


Lobular carcinoma in situ was first described as a distinct entity by Foote and Stewart in 1941 1, although there is still considerable controversy concerning the true nature of the lesion and the most appropriate terminology. Haagensen and colleagues2 consider the lesion to be precancerous and call it simply ‘lobular neoplasia’, while Toker and Goldberg3 prefer the noncommittal term ‘in situ small cell lesion’. It is usually an incidental finding in biopsies performed for other reasons, such as cystic disease, since it does not itself produce a palpable mass and it cannot be recognized macroscopically. Although lobular carcinoma in situ is sometimes found in tissue removed because of mammographic calcification, it is rare for the calcium deposits actually to be within the tumour foci; they are usually situated in adjacent non-neoplastic tissue. Pure lobular carcinoma in situ accounts for about 2–3% of all mammary carcinomas. Discrepancies in the incidence reported in the literature may be attributable to geographical variations as well as to different diagnostic criteria and thoroughness of examination of breast biopsy tissue. Lobular carcinoma shows a high incidence of multicentricity and bilaterality. Multicentricity has been estimated to be at least 70% and bilaterality at least 30–35%4.


Lobular Carcinoma Cystic Disease Duct Wall Intraduct Carcinoma Lobular Neoplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Foote, F. W. Jr. and Stewart, F. W. (1941). Lobular carcinoma in situ. Am. J. Pathol., 17, 491PubMedPubMedCentralGoogle Scholar
  2. 2.
    Haagensen, C.D., Lane, N., Lattes, R. and Bodian, C. (1978). Lobular neoplasia (so-called lobular carcinoma in situ) of the breast. Cancer, 42, 737PubMedCrossRefGoogle Scholar
  3. 3.
    Toker, C. and Goldberg, J.D. (1977). The small cell lesion of mammary ducts and lobules. In Sommers, S. C. and Rosen, P. P. (eds.) Pathology Annual, Vol. 12, pp. 217–249. ( New York: Appleton-Century-Crofts )Google Scholar
  4. 4.
    Andersen, J. A. and Schiodt, T. (1980). On the concept of carcinoma in situ of the breast. Pathol. Res. Pract., 166, 407PubMedCrossRefGoogle Scholar
  5. 5.
    Wheeler, J.E. and Enterline, H.T. (1976). Lobular carcinoma of the breast in situ and infiltrating. In Sommers, S.C. (ed.) Pathology Annual, Vol. 11, pp. 161–188, ( New York: Appleton- Century-Crofts )Google Scholar
  6. 6.
    Andersen, J.A. and Vendleboe, M.L. (1981). Cytoplasmic mucous globules in lobular carcinoma in situ. Am. J. Surg. Pathol., 5, 251PubMedCrossRefGoogle Scholar
  7. 7.
    Fechner, R. E. and Houston, M. D. (1972). Epithelial alterations in the extralobular ducts of breasts with lobular carcinoma. Arch. Pathol., 93, 164PubMedGoogle Scholar
  8. 8.
    Fechner, R. E. (1971). Ductal carcinoma involving the lobule of the breast. Cancer, 28, 274PubMedCrossRefGoogle Scholar
  9. 9.
    Fechner, R. E. (1981). Lobular carcinoma in situ in sclerosing adenosis. Am. J. Surg. Pathol., 5, 233PubMedCrossRefGoogle Scholar
  10. 10.
    Rosen, P.P., Senie, R., Schottenfeld, D. and Ashikari, R. (1979). Noninvasive breast carcinoma. Frequency of unsuspected invasion and implications for treatment. Ann. Surg., 189, 377PubMedCrossRefPubMedCentralGoogle Scholar
  11. 11.
    Rosen, P. P., Lieberman, P. H., Braun, D. W. Jr., Kosloff, C. and Adair, F. (1978). Lobular carcinoma in situ of the breast. Am. J. Surg. Pathol., 2, 225PubMedCrossRefGoogle Scholar

Copyright information

© Rosemary R. Millis 1984

Authors and Affiliations

  • Rosemary R. Millis
    • 1
  1. 1.Guy’s Hospital and Imperial Cancer Research Fund Breast Cancer Unit at Guy’s and New Cross HospitalsLondonUK

Personalised recommendations