Abstract
There are two practical ways of sampling small intestinal mucosa. Commonly a Crosby or similar capsule is swallowed, allowed to pass the ligament of Trietz and its level checked radiographically. A single ‘blind’ biopsy is taken, though some instruments allow multiple biopsies. Because visualization is impossible, only generalized lesions present at this level can be sampled. Increasingly, with the development of fibreoptics and gastroscopy, instruments are being passed through the pylorus, and duodenal biopsies taken under direct vision. It is probable that direct duodenal biopsy will have at least partly replaced blind jejunal biopsy within a few years and a knowledge of normal duodenal morphology is becoming essential to the practising histo- pathologist.
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References
Dawson, I. M. P. (1981). The value of histochemistry in the diagnosis and prognosis of gastrointestinal diseases. In Stoward, P. J. and Polak, J. M. (eds.) Histochemistry: the Widening Horizons, pp. 127–162. (Chichester: John Wiley & Sons)
Lojda, Z. (1974). Cytochemistry of enterocytes and of other cells in the mucous membrane of the small intestine. In Smyth, D. H. (ed.) Biomembranes 4A. Intestinal Absorption. (London: Plenum Press)
Robinson, G. (1982). Immunohistochemistry. In Bancroft, J. D. and Stevens, A. (eds.). Theory and Practice of Histological Techniques, 2nd Edn. pp. 406–427. (Edinburgh: Churchill Livingstone)
Grimelius, L. (1968). A silver nitrate stain for α2 cells in human pancreatic islets. Acta Soc. Med. Uppsala, 73, 243
Toner, P. G., Carr, K. E. and Wyburn, G. M. (1971). The Digestive System — An Ultrastructural Atlas and Review, pp. 55–204. (London: Butterworth)
Ferguson, A., Sutherland, A., MacDonald, T. T. and Allan, F. (1977). Techniques for microdissection and measurement in biopsies of human small intestine. J. Clin Pathol., 30, 1068
Slavin, G., Sowter, C., Robertson, K., McDermott, S. and Paton, K. (1980). Measurement in jejunal biopsies by computer-aided microscopy. J. Clin. Pathol., 33, 254
Rosenkrans, P. N. C., Meijer, C. J. L. M., Polanco, M., Mearin, M. L., van der Wal, A. M. and Lindeman, J. (1981). Long term morphological and immunohistochemical observations on biopsy specimens of small intestine from children with gluten sensitive enteropathy. J. Clin. Pathol., 34, 138
Pearse, A. G. E. and Polak, J. M. (1971). Neural crest origin of the endocrine polypeptide (APUD) cells of the gastrointestinal tract and pancreas. Gut, 12, 783
Wright, N. A., Appleton, D. R., Marks, J. and Watson, A. J. (1979). Cytokinetic studies of crypts in convoluted human small intestinal mucosa. J. Clin Pathol., 32, 432
Brandtzaeg, P. and Baklein, K. (1976). Immunohistochemical studies of the formation and epithelial transport of immunoglo-bulins in normal and diseased human intestinal mucosa. Scand. J. Gastroenterol., 11, Suppl. 36
March, M. N. (1980). Studies of intestinal lymphoid tissue III. Quantitative analysis of epithelial lymphocytes in the small intestine of human control subjects and of patients with coeliac sprue. Gastroenterology, 79, 481
Guix, M., Skinner, J. M. and Whitehead, R. (1979). Measuring intraepithelial lymphocytes, surface area and volume of lamina propria in the jejunal mucosa of coeliac patients. Gut, 20, 275
Hasan, M., Sircus, W. and Ferguson, A. (1981). Duodenal mucosal architecture in non-specific and ulcer-associated duodenitis. Gut, 22, 637
Lessels, A. M. and Martin, D. F. (1982). Heterotopic gastric mucosa in the duodenum. J. Clin. Pathol., 35, 591
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© 1983 I. M. P. Dawson
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Dawson, I.M.P. (1983). Small Intestine: Normal Biopsy Appearances. In: Atlas of Gastrointestinal Pathology. Current Histopathology, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6583-6_10
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DOI: https://doi.org/10.1007/978-94-009-6583-6_10
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