Abstract
The principle of photomedicine is the use of non-ionizing electromagnetic radiation in the ultraviolet (UV) and visible range, in the absence or in the presence of exogenous photosensitizers, to treat diseases such as porphyrias, viral infections (Herpes simplex), malignant lesions and skin diseases. For fuller discussion of the different aspects of photomedicine, see the treatise edited by Regan and Parrish, “The Science of Photomedicine” (1982).
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References
Ashwood-Smith M.J., Natarajan A.T. and Poulton G.A. (1981), Comparative photobiology of psoralens in “Psoralens in Cosmetics and Dermatology”, Proc. Int. Psoralens SIR, p. 117–131 (J. Cahn, P. Forlot, C. Grupper, A. Meybeck and F. Urbach, Eds). Pergamon Press France.
Bertaux B., Moreno G. and Dubertret L. (1981) Autoradiographic localization of 8-methoxypsoralen in psoriasis skin in vitro. Acta Dermatovener, 61, 481–485
Bishop S. (1979), DNA repair synthesis in human skin exposed to ultraviolet radiation used in PUVA (psoralen and UVA) therapy for psoriasis. Brit. J. Dermatol. 101, 399–405
Bioulac P., Denechaud M., Dubuisson L., Doutre M.S., Ducasson D. and Beylot C. (1980). Unscheduled DNA synthesis in psoriatic skin after ultraviolet irradiation and the effects of a combined treatment with 8-methoxypsoralen and longwave ultraviolet radiation: a clinical study. Brit. J. Dermatol. 102, 285–295
Bridges B.A., Greaves M., Polani P.E., and Wald N. (1981). Do treatments available for psoriasis patients carry a genetic or carcinogenic risk? Mutat. Res. 86, 279–304
Burger P.M. and Simons J.W.I.M. (1979). Mutagenicity of 8-methoxypsoralen and long-wave ultraviolet irradiation in diploid human skin fibroblasts. An improved risk estimate in photochemotherapy. Mutat. Res. 63, 371–380
Cech T., Pathak M.A. and Biswas R.K. (1970). An electron microscopic study of the photochemical cross-linking of DNA in guinea pig epidermis by psoralen derivatives. Biochim. Biophys. Acta 562, 342–360
Dubertret L., Averbeck D., Zajdela F., Bisagni E., Moustacchi E., Touraine R. and Latarjet R. (1979). Photochemotherapy (PUVA) of psoriasis using 3-carbethoxypsoralen, a non-carcinogenic compound in mice. Brit. J. Dermatol. 101, 379–389.
Dubertret L., Santus R., Bazin M. and Sae Melo T. (1982). Photochemistry in human epidermis. A quantitative approach. Photochem Photobiol. 35, 103–107
Grekin D.A. and Epstein J.H. (1981) Psoralens, UVA (PUVA) and Photocarcinogenesis. Photochem. Photobiol. 33, 957–960
Hanawalt P.C., Cooper P.K., Ganesan A.K. and Smith C.A. (1979). DNA repair in bacteria and mammalian cells. Ann. Rev. Biochem. 18, 783–836
Hanawalt P.C., Liu S.C. and Parsons C.S. (1981a). DNA repair responses in human skin cells. J. Invest. Dermatol. 77, 86–90
Hanawalt P.C., Kaye J., Smith C.A. and Zolan M. (1981b). Cellular responses to psoralen adducts in DNA. “Psoralens in Cosmetics and Dermatology”, Proc. Int. Psoralens SIR p. 133–142. (J. Cahn, P. Forlot, C. Grupper, A. Meybeck and F. Urbach, Eds) Pergamon Press France
Helene, C. (1980). Furocoumarines et Photochimiotherapie. Pathol. Biol. 28, 281–285
Hönigsmann H., Jaenicke K.F., Brenner W., Rauschmeier W. and Parrish J.A. (1981). Unscheduled DNA synthesis in normal human skin after single and combined doses of UV-A, UV-B and UV-A with methoxsalen (PUVA). Brit. J. Dermatol. 105, 491–501
Lerche A., Sondergaard J., Wadskov S., Leick V. and Bohr V. (1979) DNA interstrand cross links visualized by electron microscopy in PUVA-treated psoriasis. Acta Dermatovener. 59, 15–20
Moreno G., Salet C., Kohen C. and Kohen E. (1982). Penetration and localization of furocoumarins in single living cells studied by microspectrofluorimetry. Biochim. Biophys. Acta 721, 109–111
Parrish J.A., Fitzpatrick T.B., Tanenbaum L. and Pathak M.A. (1974) Photochemotherapy of psoriasis with oral methoxsalen and long-wave ultraviolet light. N. Engl. J. Med. 291, 1207–1211
Parsons B.J. (1980). Psoralen photochemistry. Photochem. Photobiol. 32, 813–821
Pathak M.A., West J.D. and Mullen M.P. (1982). Photosensitizing and carcinogenic properties of mono-and bi-functional psoralens. Proc. 10th Ann. Meeting Ann. Soc. Photobiol. Vancouver 1982. abstract MAM-D9, p. 67
Regan J.D. and Parrish J.A., The Science of Photomedicine, New York, Plenum Press, 1982, in press
Rodighiero G. and Dall’Acqua F. (1976). Biochemical and medical aspects of psoralens. Photochem. Photobiol. 24, 647–653
Salet C., Moreno G. and Vinzens F. (1982). Photodynamic effects induced by furocoumarins on a membrane system. Comparison with hematoporphyrin. Photochem. Photobiol. 36, 291–296
Scott B.R., Pathak M.A. and Mohn G.R. (1976). Molecular and genetic basis of furocoumarin reactions. Mutat. Res. 39, 29–74
Song P.S. and Tapley K.J. (1979) Photochemistry and photobiology of psoralens. Photochem. Photobiol. 29, 1177–1197
Stern R.S., Thibodeau L.A., Kleinerman R.A., Parrish J.A. and Fitzpatrick T.B. (1979). Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis. N. Engl. J. Med. 300, 809–813
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© 1984 Martinus Nijhoff Publishers, The Hague
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Moreno, G. (1984). Photobiology of Furocoumarins (Psoralens) and Recent Developments in the Photochemotherapy (PUVA) of Psoriasis. In: Dendy, P.P., Ernst, D.W., Şengün, A. (eds) Technical Advances in Biomedical Physics. NATO ASI Series, vol 77. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6125-8_12
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DOI: https://doi.org/10.1007/978-94-009-6125-8_12
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