Calcium-ions and excitation contraction coupling in vascular smooth muscle cells

  • R. Casteels
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 40)


Calcium entry, release and extrusion are essential parameters in determining the activity of smooth muscle cells. Modification of any of these parameters by pharmacological means could have important therapeutic implications. However, we should also be aware of the fact that Ca2+ is not the only secondary messenger in smooth muscle, and that therefore pharmacological agents not necessarily always act by changing the Ca metabolism of smooth muscle cells.


Smooth Muscle Cell Sarcoplasmic Reticulum Rabbit Aorta Smooth Muscle Tissue Taenia Coli 
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L’entrée des ions calciques, leur libération et leur extrusion sont des processus essentiels déterminant l’activité des muscles lisses. La modification d’un de ces processus par des agents pharmacologiques peut mener à des implications thérapeutiques importantes. Cependant, le Ca2+ n’est pas le seul messager secondaire dans le muscle lisse et, par conséquent, l’effet des agents pharmacologiques n’y est pas toujours nécessairement dû à un changement du métabolisme calcique.


La penetración, liberación y expulsión de calcio son parámetros esenciales en la determinación de la actividad de las células musculares Iisas. La modificación de cualquier de estos parámetros por medio de fármacos podría tener implicaciones terapéuticas importantes. No obstante, ha de tenerse en cuenta el hecho de que Ca2+ no es el único agente secundario en el músculo liso, y que por eso los agentes farmacológicos no siempre actúan necesariamente cambiando el metabolismo de calcio en las células musculares lisas.


Kalziumeintritt, -freisetzung und -Verdrãngung sind essentielle Parameter, die die Aktivität der glatten Muskeln bestimmen. Die Veränderung eines dieser Parameter durch pharmakologischen Mittel kann wichtige therapeutische Folgen haben. Wir sollen jedoch berücksichtigen, dass Ca2+ nicht der einzige sekundäre Botenstoff in den glatten Muskeln ist und dass pharmakologische Stoffe daher nicht immer notwendigerweise dadurch wirken, dass sie den Ca-Stoffwechsel in der glatten Muskulatur ändern.


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© Martinus Nijhoff Publishers, The Hague 1984

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  • R. Casteels

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