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Enhanced transcardiac 1-norepinephrine response during cold pressor test in obstructive coronary artery disease

  • Chapter
Coronary Tone in Ischemic Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 38))

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Abstract

Studies during the past decade have demonstrated that sympathetic nervous activity can play an important role in the regulation of coronary blood flow. It became apparent that alpha adrenergic mediated coronary vasoconstriction can compete with metabolically-induced coronary vasodilatation, particularly in myocardial regions with decreased coronary reserve [1–7]. Recent studies have also emphasized that increased sympathetic nervous activity enhanced ventricular irritability and lowers the threshold to ventricular fibrillation in the ischemic myocardium [8–11]. Since these observations suggest that increases in sympathetic nervous activity could place the patient with obstructive coronary artery disease at increased risk, we measured arterial and coronary sinus 1-norepinephrine contents during relatively mild sympathetic stress in this patient category and compared their response of transcardiac 1-norepinephrine pattern to that in patients with normal coronary arteries. We selected cold pressor stimulation because it is probably similar to the level of sympathetic stress experienced frequently during daily life. Our data indicate that there is a substantially greater increase in coronary sinus 1-norepinephrine concentrations in the patients with obstructive coronary artery disease compared to those without disease.

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Authors
  1. Hiltrud S. Mueller
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  2. Parinam S. Rao
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  3. Pullipaka B. Rao
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  4. Dennis J. Gory
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  5. Stephen M. Ayres
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Editor information

Editors and Affiliations

  1. Department of Cardiology, University Hospital Hamburg, Eppendorf, Germany

    Wolfram Kupper MD  & Walter Bleifeld MD  & 

  2. Department of Cardiology, University of California, Los Angeles, USA

    Rex N. MacAlpin MD

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© 1984 Martinus Nijhoff Publishers, Boston/The Hague/Dordrecht/Lancaster

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Mueller, H.S., Rao, P.S., Rao, P.B., Gory, D.J., Ayres, S.M. (1984). Enhanced transcardiac 1-norepinephrine response during cold pressor test in obstructive coronary artery disease. In: Kupper, W., MacAlpin, R.N., Bleifeld, W. (eds) Coronary Tone in Ischemic Heart Disease. Developments in Cardiovascular Medicine, vol 38. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6021-3_11

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  • DOI: https://doi.org/10.1007/978-94-009-6021-3_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6023-7

  • Online ISBN: 978-94-009-6021-3

  • eBook Packages: Springer Book Archive

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