Abstract
The complexity and wide range of organic acids present in urine, and other biological fluids, makes their quantification and positive identification a difficult problem. Although chromatographic characteristics of individual compounds, such as retention data on gas, liquid and thin-layer chromatography, are extremely useful indicators of probable identity, it is necessary to use a technique with sufficient specificity to make a positive identification of a chromatographically separated component. Infra-red spectroscopy, for example, may be suitable when enough material in a pure form is available. In the case of a total urinary organic acid extract, such an approach is only practical on a very limited scale owing to the large number and wide variation in concentration of the components.
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© 1982 R. A. Chalmers and A. M. Lawson
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Chalmers, R.A., Lawson, A.M. (1982). Gas chromatography-mass spectrometry. In: Organic Acids in Man. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5778-7_5
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DOI: https://doi.org/10.1007/978-94-009-5778-7_5
Publisher Name: Springer, Dordrecht
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Online ISBN: 978-94-009-5778-7
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