Abstract
Of the three approaches to selectivity outlined in Chapter 2, this one has proved particularly successful in developing new and much used agents. In retrospect, it is astonishing how slowly comparative biochemistry developed as a subject of enquiry. Baldwin’s book An Introduction to Comparative Biochemistry first appeared in 1937 and opened many eyes to the interest and possibilities of the subject. The last two decades have seen a steady growth of activity in comparative biochemistry, and today it is a thriving and successful subject.
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References
Murray, A.W. (1966), Biochem. J., 100, 664–674.
Dixon, M. and Webb, E. (1964), Enzymes, 2nd Edn, Longmans, London, 782 pp.
Gale, E.F., Cundliffe, E., Reynolds, P.E., Richmond, M.H., and Waring, M.J. (1972), ‘The Molecular Basis of Antibiotic Action’ Wiley, London, 456 pp.
Mansour, T.E. and Bueding, E. (1954), Brit. J. Pharmacol. Chemother., 9, 459–462; Bueding, E. and Fisher, J. (1966), Biochem. Pharmacol, 15, 1197-1211.
Färber, S. (1952), Blood, 7, 107–112; Zuelzer, W.W. (1964), Blood, 24, 477-494.
Brulé, G., Eckhardt, S.J., Hall, T.C., and Winkler, A. (1973), Drug Therapy of Cancer, World Health Organization, Geneva, 163 pp.
Wood, R.C., Ferone, R., and Hitchings, G.H., (1961), Biochem. Pharmacol., 6, 113–124.
Falco, E.A., Goodwin, L.G., Hitchings, G.H., Rollo, I.M., and Russell, P.B. (1951), Brit. J. Pharmacol. Chemother., 6, 185–200.
Baker, B.R. and Shapiro, H.S. (1966), J. Pharm. Sci., 55, 308–317.
Burchall, J., and Hitchings, G.H. (1965), Molec. Pharmacol. 1, 126–136.
Ferone, R., Burchall, J., and Hitchings, G.H. (1969), Molec. Pharmacol., 5, 49–58.
Jaffe, J.J. and McCormack, J.J. (1967), Molec. Pharmacol., 3, 359–369.
Roth, B., Falco, E.A., and Hitchings, G.H. (1962), J. Med. Pharm. Chem., 5, 1103–1123.
Cattell, W., Chamberlain, D., Fry, I., McSherry, M., Broughton, C, and O’Grady, F. (1971), Brit. Med. J., 1, 377–379.
Richards, W.H.G. (1970), Adv. Pharmacol Chemother., 8, 121–147.
Hurly, M. (1959), Trans. Roy. Soc. Trop, Med. Hyg., 53, 410–412.
Hartley, B.S. and Kilby, B.A. (1952), Biochem. J., 50, 672–678.
O’Brien, R.D. (1967), Insecticides, Action, and Metabolism, Academic Press, N.Y., 332 PP.
Lee, R.M. and Hodsden, M.R. (1963), Biochem. Pharmacol., 12, 1241–1252.
Krueger, H.R. and O’Brien, R.D. (1959), J. Econ. Entomol., 52, 1063–1067.
Krueger, H.R., O’Brien, R.D., and Dauterman, W.C. (1960), J. Econ. Entomol., 53, 25–31.
Casida, J.E., McBryde, L., and Niedermeir, R.P. (1962), J. Agric. Food. Chem., 10, 370–377.
Ashe, H.B. (1964), Arch. Environ. Health, 9, 545–554.
Davies, J.H., Campbell, W.R., and Kearns, C.W. (1910), Biochem. J., 117, 221–230.
Levine, R.J., Hall, T.C., and Harris, C.A. (1963), Cancer, 16, 269–272.
Levy, D. and Boiron, M. (1969), Bulletin de Cancer, France, 56, 365–374 (in French).
Yamamoto, I. (1970), Ann. Rev. Entomol., 15, 257–272
Tolmsoff, W.J. (1962), Phytopathology, 52, 755 pp.
Gysin, H. (1962), Chem. and Indust., 1393–1400.
Gibson, F. (1964), Biochem. J., 90, 256–261
Goodwin, T.W. (ed.) (1965), Aspects of Insect Biochemistry (Biochem. Soc. Symposia, 25), London, Academic Press, 107 pp.
Mansour, T.E. (1964), Adv. Pharmacol., 3, 129–165.
O’Brien, I.G., Cox, G.B., and Gibson, F. (1971), Biochim. Biophys. Acta, 237, 537–549.
Krebs, H.A. (1965), Endeavour, 16, 125–132.
Rogers, E., and 12 others (1960), J. Amer. Chem. Soc., 82, 2974–2975.
Buchanan, J.M., Flaks, J.G., Hartman, S.C., Levenberg, B., Lukens, L.N., and L. Warren., in Chemistry and Biology of Purines (Ciba Symposium) (ed. Wolstenholme, G. and O’Connor, C), Churchill, London, 233–255).
Reyes, P. and Heidelberger, C. (1965), Molec. Pharmacol., 1, 14–30.
Kaufman, H.E. (1962), Proc. Soc. Exper. Biol. Med., 109, 251–252.
Kaplan, A.S. and Ben-Porat, T. (1966), J. Molec. Biol., 19, 320–332.
Kim, J.H. and Eidinoff, M.L. (1965), Cancer Res., 25, 698–702.
Chow, A.W., Foerster, J., and Hryniuk, W. (1970), Antimicrob. Agents Chemother., 214–217.
Elion, G.B., Kovensky, A., Hitchings, G.H., Metz, E., and Rundles, R.W. (1966), Biochem. Pharmacol., 15, 863–869.
Iversen, L.L. (1967), ‘The Uptake and Storage of Noradrenaline in Sympathetic Nerves’, University Press, Cambridge, 253 pp.
Bovet, D. (1947), RendacontiIstituto superiore di Sanitá, Rome, 10, 1161–1193.
Paton, W.D.M. (1961), Proc. Roy. Soc, B, 154, 21–69.
Lipscombe, W. (1970), Accounts of Chemical Research, (Amer. Chem. Soc), 3, 81–89.
Katz, B. and Thesleff, S. (1957), J. Physiol., Lond., 138, 63–80.
Grollman, A.P. (1968), J. Biol. Chem., 243, 4089–4094.
Goss, W.A., Deitz, W.H. and Cook, T.M.(1965), J. Bact., 89, 1068–1074.
Färber, S. and Mitus, A. (1968) in ‘Actinomycin’ (ed. Waksman, S.), Wiley, N.Y. 231 pp.
Tamm, I., Eggers, H.J., Bablanian, R., Wagner, A.F., and Folkers, K. (1969), Nature, Lond. 223, 785–788.
Grigg, G.W. (1970), Molec Gen. Genetics, 106, 228–238.
Suggestions for further reading
Albert, A. (1973), Selective Toxicity, 5th edn., Chapman and Hall, London, 597 pp. Covers the territory of this chapter, but in greater depth.
Florkin, M. and Mason, H. (1960-1964), Comparative Biochemistry (7 vols) Academic Press, N.Y. A rich source of reference; however, many advances have taken place since 1964.
Franklin, T.J. and Snow, G.A. (1971), ‘Biochemistry of Antimicrobial A ction’, Chapman and Hall, London, 152 pp. Discusses mainly substances of microbial origin such as mycobactins and tetracyclines.
Gale, E.F., et al, (as Ref. 3, above). Experienced investigators discuss the molecular basis of antibiotic action.
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Albert, A. (1975). Favourable differences in biochemistry: the second principle of selectivity. In: The Selectivity of Drugs. Outline Studies in Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5734-3_5
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DOI: https://doi.org/10.1007/978-94-009-5734-3_5
Publisher Name: Springer, Dordrecht
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