Abstract
The Russian surgeon Demikhov was responsible for the first serious experimental work in combined heart and lung transplantation (1). In 1946 he achieved survival of a dog for two hours after heart-lung transplantation. His efforts were hampered by the lack of cardiopulmonary bypass, and Webb and Howard, using cardiopulmonary bypass (2) then achieved survival for 22 h. Lower and associates in 1961 (3) achieved six day survival with these techniques, but it was noted that disturbance of the respiratory pattern, presumably as a result of denervation, was the primary impairment to long-term survival. The longest reported survival after cardiopulmonary transplantation in dogs was accomplished by Grinnan and associates in 1970 (4), with one 10 day survivor from 25 transplants.
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References
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© 1984 Martinus Nijhoff Publishers, The Hague
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Jamieson, S.W., Stinson, E.B., Oyer, P.E., Theodore, J., Hunt, S., Shumway, N.E. (1984). Heart-lung transplantation. In: Abouna, G.M., White, A.G. (eds) Current Status of Clinical Organ Transplantation. Developments in Surgery, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5674-2_29
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DOI: https://doi.org/10.1007/978-94-009-5674-2_29
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