Clinical pancreas and islet transplantation: registry statistics and an overview

  • David E. R. Sutherland
Part of the Developments in Surgery book series (DISU, volume 5)


Interest in the application of clinical pancreas transplantation has increased dramatically recently, as evidenced by the fact that nearly as many pancreas transplants have been performed in the last two years (1981–1982) as in the preceding 14 years following the first pancreas transplantation in 1966 (14). The potential of pancreas and islet transplantation as treatments for Type I diabetes approximates that of kidney transplantation for treatment of end stage renal disease.


Kidney Transplant Islet Transplantation Pancreas Transplantation Exogenous Insulin Functioning Graft 
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  1. 1.
    Bart KJ, Macon EJ, Whittier FC, Baldwin PJ, Blaunt JH: Cadaveric kidneys for transplantation. A paradox of shortage in the face of plenty. Transplantation 31: 374–382, 1981.Google Scholar
  2. 2.
    Baumgartner D, Largiader F, Uhlschmid G, Binswanger U: Rejection of simultaneous pancreas and kidney transplants. Transpl Proc 15(1): 1330–1331, 1983.Google Scholar
  3. 3.
    Brownlee MC, Cahill GF: Diabetic control and vascular complications. Atherosclerotic Reviews, Vol 4 (Paoletti R, Gatto AM eds). Raven Press, New York, pp 29–70, 1979.Google Scholar
  4. 4.
    Buchwald H, Rupp WM, Rhode JD, Barbosa J, Dorman FD, Blackshear PJ, Varco RL, Steffes MW, Mauer SM: Implantable insulin pump: insulin infusion in animals and man. Trans Am Soc Art Int Organs 28: 687–690, 1982.Google Scholar
  5. 5.
    Calne RY, White DJG: The use of cyclosporine in clinical organ grafting. Ann Surg 196: 330–337, 1982.PubMedCrossRefGoogle Scholar
  6. 6.
    Clark WH (ed): Proceedings of a Workshop on Preventing Rejection of Transplanted Pancreas or Islets. Diabetes 31 (Suppl 4): 1–111, 1982.Google Scholar
  7. 7.
    Dubernard JM, Traeger J, Possa G et al: Clinical experience with 31 pancreatic transplants in man. Transpl Proc 15(1): 1318–1321, 1983.Google Scholar
  8. 8.
    Faustman D, Hauptfeld V, Lacy P, Davie J: Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to la determinants. Proc Natl Acad Sci USA 78: 8, 5156–5159, 1981.PubMedCrossRefGoogle Scholar
  9. 9.
    Florack G, Sutherland DER, Heil J, Zweber B, Najarian JS: Long term preservation of segmental pancreas autografts. Surgery 92: 260–269, 1982.PubMedGoogle Scholar
  10. 10.
    Gerrish EW: Final Newsletter, American college of Surgeons/National Institutes of Health Organ Transplant Registry, June 30, 1977.Google Scholar
  11. 11.
    Groth CG, Lundgren G, Klintman G et al: Successful outcome of segmental pancreas transplantation with Roux-en-Y jejunal diversion after modification in technique. Lancet 2: 522–524, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Groth Cg, Lundgren G, Ostman J, Gunnarsson R: Experience with nine segmental pancreatic transplantations in pre-uremic diabetic patients in Stockholm. Trans Proc 12 (No 4, Suppl 2): 68–71, 1980.Google Scholar
  13. 13.
    Health Care Financing Administration (HCFA) Office of Special Programs. End-Stage Renal Disease Program Medical Information System, Facility Survey Tables, Department of Health and Human Services, USA, HCFA. January 1-December 31, 1981.Google Scholar
  14. 14.
    Kelly WD, Lillehei RC, Merkel FK, Idezuki Y, Goetz FC: Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 61: 827–837, 1967.PubMedGoogle Scholar
  15. 15.
    Kolb E, Largiader F: Transplantation of pancreatic microfragments in patients with juvenile diabetes. In: Islet Isolation, Culture and Cryopreservation (Eds. Federlin K, Bretzeleds). RG Georg Thieme Verlag, Stuttgart-New York, pp 188–194, 1981.Google Scholar
  16. 16.
    Lacy PE, Lacy ET, Finke EH, Yasunami Y: An improved method for the isolation of islets from the beef pancreas. Diabetes 31 (Suppl 2): 109–111, 1982.PubMedGoogle Scholar
  17. 17.
    Largiader F, Kolb E, Binswanger U: A long term functioning human pancreatic islet allotransplant. Transplantation 39: 76–77, 1980.CrossRefGoogle Scholar
  18. 18.
    Lillehei RC, Simmons RL, Najarian JS, Weil R III, Uchida H, Ruiz JO, Kjellstrand CM, Goetz FC: Pancreaticoduodenal allotransplantation. Experimental and clinical experience. Ann Surg 172: 405–436, 1970.PubMedCrossRefGoogle Scholar
  19. 19.
    McMaster P, Gibby OM, Calne RY et al: Pancreatic transplantation. J Roy Soc Med 75: 47–51, 1982.Google Scholar
  20. 20.
    Opelz G, Terasaki PI: International study of histocompatibility in renal transplantation. Transplantation 3: 87–95, 1982.CrossRefGoogle Scholar
  21. 21.
    Rosenbloom AL, Silverstein JH, Lezotte DC, Richardson K, McCallum RN: Limited joint mobility in childhood diabetes mellitus indicates increased risk for microvascular disease. N Eng J Med 305: 191–194, 1981.CrossRefGoogle Scholar
  22. 22.
    Sutherland DER: Current status of clinical pancreas and islet transplantation with comments on need for and complications of cyrogenic and other preservation techniques. Cryobiology (1983, in press).Google Scholar
  23. 23.
    Sutherland DER: Current status of pancreas transplantation: Registry statistics and an overview. Transpl Proc 15(1) (1983, in press).Google Scholar
  24. 24.
    Sutherland DER: International human pancreas and islet transplant registry. Transpl Proc 12 (No 4, Suppl 2): 229–236, 1980.Google Scholar
  25. 25.
    Sutherland DER: Pancreas and islet transplantation. I. Experimental Studies. Diabetologia 20: 161–185, 1981.PubMedGoogle Scholar
  26. 26.
    Sutherland DER: Pancreas and islet transplantation. II. Clinical trials. Diabetologia 20: 435–450, 1981.PubMedGoogle Scholar
  27. 27.
    Sutherland DER, Goetz FC, Elick BA, Najarian JS: Experience with 49 segmental pancreas transplants in 45 diabetic patients. Transplantation 34: 330–338, 1982.PubMedCrossRefGoogle Scholar
  28. 28.
    Sutherland DER, Goetz FC, Elick BA, Najarian JS: Pancreas transplantation for diabetes: Clinical experience and metabolic studies in 54 recent cases at the University of Minnesota. Transpl Proc 15(1): 1322–1326, 1983.Google Scholar
  29. 29.
    Sutherland DER, Goetz FC, Najarian JS: Pancreas Organ Transplantation. Clin Endocrin & Metabol 11: 549–578, 1982.CrossRefGoogle Scholar
  30. 30.
    Sutherland DER, Goetz FC, Najarian JS: Living related donor segmental pancreatectomy for transplantation. Transpl Proc 12 (No 4, Suppl 2): 19–25, 1980.Google Scholar
  31. 31.
    Sutherland DER, Morrow CE, Fryd DS, Ferguson RM, Simmons RL, Najarian JS: Improved patient and renal allograft survival in uremic diabetic patients. Transplantation 34: 319–325, 1982.PubMedCrossRefGoogle Scholar
  32. 32.
    Toledo-Pereyra LH, Mittal VK: Segmental pancreas transplantation. Arch Surgery 171: 505–508, 1982.CrossRefGoogle Scholar
  33. 33.
    Ungar RH: Meticulous control of diabetes: Benefits, risks and precautions. Diabetes 31: 479–483, 1982.Google Scholar
  34. 34.
    White N, Skor DA, Cryer PE, Levandoski PA, Bier DM, Santiago JV: Identification or Type I diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 308: 485–491, 1983.PubMedCrossRefGoogle Scholar
  35. 35.
    West KM: Epidemiology of diabetes and its vascular lesions. Elsevier, New York, 1978.Google Scholar

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© Martinus Nijhoff Publishers, The Hague 1984

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  • David E. R. Sutherland

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