A new approach to prolonged kidney preservation

  • G. Kootstra
  • B. G. Rijkmans
  • W. A. Buurman
Part of the Developments in Surgery book series (DISU, volume 5)


Nowadays, 48 h are available in clinical kidney transplantation, for matching and transportation of kidneys. Preservation, by either cold storage or hypothermic perfusion, permits these 48 h, sometimes with damage to kidney function, which is usually reversible within a few days. There are some reports in literature (1, 2) where preservation times over 48 h, and up to 90 h are mentioned. Nevertheless, transplant surgeons prefer to transplant a kidney within 48 h, and more time is seldom needed. Only when extended preservation times up to one week (intermediate term) are realized, will new immunological techniques intended to improve the results of clinical kidney transplantation and world-wide sharing of kidneys, necessary to reduce wastage of kidneys, become reality. Therefore research in the field of kidney preservation continues in several laboratories over the world.


Blood Perfusion Organ Preservation Organ Chamber Plasma Protein Fraction Preservation Period 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Abouna GM, Kumar AS, White AG, Daddah S, Omer OF, Samhan M, Kusma G, John P, Soubky AS, Abbas AR, Kremer G: Experience with imported human cadaveric kidneys having unusual problems and transplanted after 30-60 hours of preservation. Transplant Proceed 16: 61, 1984.Google Scholar
  2. 2.
    Squifflet JP, Pirson Y, Gianello P, Van Caugh P, Alexandre GPJ: Safe preservation of human renal cadaver transplants by Euro-Collins solution up to 50 hours. Transplant Proc 13: 693–696, 1981.PubMedGoogle Scholar
  3. 3.
    Kootstra G, Van der Wijk J, Rijkmans BG: A New device towards intermediate term kidney preservation. An experimental study. (Suppl) Scand J Urol Nephrol 54: 86–89, 1980.Google Scholar
  4. 4.
    Cohen GL, Johnson RWG: Perfusate Buffering for 8-day canine kidney storage. Proc Eur Soc Art Org VII: 235–239, 1980.Google Scholar
  5. 5.
    Woods JE: Successful Three-to-Seven-Day Preservation of Canine Kidneys. Arch Surg 102: 614–617, 1971.PubMedCrossRefGoogle Scholar
  6. 6.
    Liu WP, Humphries AL, Russell R, Stoddard LD, Garcia LA, Serkes KD: Three-and seven-day perfusion of dog kidneys with human plasma protein fraction IV-4. Surgical Forum 24: 316–318, 1973.PubMedGoogle Scholar
  7. 7.
    Cohen GL, Ballardie FW, Mainwaring A, Johnson RWG: Lysosomal enzyme release during successful 5-, 7-and 8-day canine kidney storage. In: Organ Preservation. Basic and Applied Aspects. (Pegg DE, Jacobsen IA, Halasz NA eds). MTP Press Ltd, Lancaster-Boston The Hague, 1982, p 249–253.Google Scholar
  8. 8.
    Ozaki A, Fukao K, Sano M, Okamura T, Iwasaki Y: Five-day preservation of canine kidneys using a preservation machine. In: Organ Preservation. Basic and Applied Aspects. (Pegg DE, Jacobsen IA, Halasz NA eds). MTP Press Ltd, Lancaster-Boston-The Hague, 1982, p 245–249.Google Scholar
  9. 9.
    Rijkmans BG, Van der Wijk J, Donker AJM, Slooff MJH, Kootstra G: Functional studies in 6 days successful preserved canine kidneys. J Urol 127: 163–165, 1982.PubMedGoogle Scholar
  10. 10.
    Toledo-Pereyra LH, Condie RM, Malmberg R, Simmons RL, Najarian JS: A fibrinogen-free plasma perfusate for preservation of kidneys for one hundred and twenty hours. Surg Gyn Obst 138: 901–906, 1974.PubMedGoogle Scholar
  11. 11.
    Van der Wijk J, Slooff MJH, Rijkmans BG, Kootstra G: Successful 96 and 144 hour experimental kidney preservation: a combination of standard machine preservation and newly developed normothermic ex-vivo perfusion. Cryobiology 17: 473–477, 1980.PubMedCrossRefGoogle Scholar
  12. 12.
    Van der Wijk J, Rijkmans BG, Kootstra G: Six day kidney preservation in a canine model. Influence of a 1 to 4 hr ex-vivo perfusion interval. Transplantation 35(5): 408–411, 1983.PubMedCrossRefGoogle Scholar
  13. 13.
    Rijkmans BG, Kootstra G, Van der Wijk J, Nizet A: In: Organ Preservation. Basic and Applied Aspects. (Pegg DE, Jacobsen IA, Halasz NA eds). MTP Press Ltd, Lancaster-Boston-The Hague, 1982, p 267–272.Google Scholar
  14. 14.
    Abouna GM, Lim F, Cook JS, Grubb W, Craig SS, Seible HR, Hume DM: Three-day canine kidney preservation. Surgery 71: 436–444, 1972.PubMedGoogle Scholar
  15. 15.
    Van der Wijk J, Rijkmans BG, Kootstra G: Light microscopic findings in intermediate term preservation. In: Organ Preservation. Basic and Applied Aspects. (Pegg DE, Jacobsen IA, Halasz NA eds). MTP Press Ltd, Lancaster-Boston-The Hague, 1982, p 239–243.Google Scholar
  16. 16.
    Lapchinsky AG: Recent results of experimental transplantation of preserved limbs and kidneys and possible use of this technique in clinical practice. Ann NY Acad Sci 87: 539–571, 1960.PubMedCrossRefGoogle Scholar
  17. 17.
    Spector D, Limas C, Frost JL, Zachary JB, Stenoff S, Williams GM, Rolley RT, Sadler JH: Perfusion nephropathy in human transplants. N Engl J Med 295: 1217–1221, 1976.PubMedCrossRefGoogle Scholar
  18. 18.
    Hill GS, Light JA, Perloff LJ: Perfusion-related injury in renal transplantation. Surgery 79: 440–447, 1976.PubMedGoogle Scholar
  19. 19.
    Cerra FB, Raza S, Andres G A, Siegel JH: The endothelial damage of pulsatile renal preservation and its relationship to perfusion pressure and colloid osmotic pressure. Surgery 81: 534–541, 1977.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, The Hague 1984

Authors and Affiliations

  • G. Kootstra
  • B. G. Rijkmans
  • W. A. Buurman

There are no affiliations available

Personalised recommendations