Abstract
An understanding of the normal mechanism of coagulation and the body’s defense mechanisms to prevent excessive coagulation is an essential basis for the understanding of the use of anticoagulants in cardiopulmonary bypass. There are three main components to normal coagulation: the vasculature, platelets and the coagulation cascade. These all participate in an interrelated fashion in normal hemostasis.
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References
Weiss HJ: Platelet physiology and abnormalities of platelet function. NEJM 293(11):531–541, 1975
Deykin D: Emerging concents of platelet function. NEJM 290(3): 144–151, 1974
Salzman EW: Cyclic AMP and platelet function. NEJM 286:358–363, 1972
Shattil SJ, Bennett JS: Platelets and their membranes in hemostasis: Physiology and Pathophysiology. Ann Intern Med 94:108–118, 1980
Lewy RI, Weener L, Smith JB, Walinsky P, Silver MJ, Saia J: Comparison of plasma concentrations of thromboxan B2 in Poinzmental’s variant angina and classical angina pectors. Clin Card 2:404, 1979
Sobel M, Salzman EW, Davies GC, Hardin RI, Sweeney J, Ploetz J, Gurland G: Circulating platelet products in unstable angina pectoris. Circ 63(2):300–306, 1981
Robertson RM, Robertson D, Roberts LJ, Maas RL, Fitzgerald GA, Friesinger GC, Oates JA: Thromboxane A2 in vasotonic angina pectoris. NEJM 304(17): 998–1003, 1981
Frishman WH, Weksler B, Christodoulou JP, Smithen C, Killip T: Reversal of abnormal platelet aggregability and change in exercise tolerance in patients with angina pectoris following oral propranolol. Circulation 50:887, 1974
Weily HS, Steele PP, Davies H, Pappas G, Genton E: Platelet survival in patients with substitute heart valves. NEJM 290(10): 534–536, 1974
Steele P, Battock D, Pappas G, Genton E: Correlation of platelet survival time with occlusion of saphenous vein aorto-coronary bypass grafts. Circulation 53(4):685–690, 1976
The Anturane Preinfarction Trial Research Group: Sulfinpyrazone in the prevention of sudden death after myocardial infarction. NEJM 302(5):250–256, 1980
Bayley T, Clements JA, Osbahr AJ: Pulmonary and circulatory effects of fibrinopeptides. Circ Res 21:469–484, 1967
McInglis TC, Breeze GR, Stuart J, Abrams LD, Roberts KD, Singh SP: Excess intravascular coagulation complicating low cardiac output. J Clin Pathol 28:1–7, 1975
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© 1984 Martinus Nijhoff Publishers, Boston
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Glass, D.D. (1984). The Coagulation System: What we Monitor and How. In: Stanley, T.H., Petty, W.C. (eds) Anesthesia and the Cardiovascular System. Developments in Critical Care Medicine and Anesthesiolgy, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5668-1_15
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DOI: https://doi.org/10.1007/978-94-009-5668-1_15
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-9001-8
Online ISBN: 978-94-009-5668-1
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