Clostridium Difficile and Colonization Resistance

  • Fiona E. Barclay
  • S. P. Borriello
Part of the Developments in Gastroenterology book series (DIGA, volume 5)


At birth the human intestine is sterile but very quickly becomes colonized with a wide variety of bacterial species, derived formerly from the mother and then from the environment. Eventually, the acquisition of new species ceases and the composition of the flora stabilises so that, in healthy individuals, host and microflora live in harmony. This relationship is important, for although the presence of an indigenous microflora is not essential for life, as is evident from the existence of gnotobiotic animals, it does exert an influence over the normal physiological functioning of the gastrointestinal tract. This includes control of fat absorption and cholic acid hydrolysis, metabolism of bilirubin, protein and urea into ammonia and the synthesis of vitamins from dietary substrate.


Intestinal Flora Normal Flora Clostridium Botulinum Toxigenic Strain Colonization Resistance 
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Copyright information

© Martinus Nijhoff Publishers, Boston 1984

Authors and Affiliations

  • Fiona E. Barclay
  • S. P. Borriello

There are no affiliations available

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