Interaction of Clostridium Difficile Toxin B (Cytotoxin) with Cultured Cells
Two toxins from C. difficile have been described (see Lyerly and Wilkins, this volume), both of which appear important in the etiology of antibiotic-associated colitis (AAC) (Libby et al. 1982). Toxin A causes fluid accumulation in rabbit ileal loops and is thus referred to as an enterotoxin, while toxin B is devoid of enterotoxic activity (Taylor et al. 1981; Sullivan et al. 1982). Both toxins are cytopathogenic, i.e. induce morphological changes in cultured mammalian cells. Toxin B, however, is active at very much lower concentrations than toxin A (Donta et al. 1982; Libby and Wilkins, 1982).
KeywordsTetanus Toxin Cellular Internalization Toxin Exposure Endocytotic Vesicle Lysosomotropic Agent
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