Interaction of Clostridium Difficile Toxin B (Cytotoxin) with Cultured Cells

  • Monica Thelestam
  • Inger Florin
Part of the Developments in Gastroenterology book series (DIGA, volume 5)


Two toxins from C. difficile have been described (see Lyerly and Wilkins, this volume), both of which appear important in the etiology of antibiotic-associated colitis (AAC) (Libby et al. 1982). Toxin A causes fluid accumulation in rabbit ileal loops and is thus referred to as an enterotoxin, while toxin B is devoid of enterotoxic activity (Taylor et al. 1981; Sullivan et al. 1982). Both toxins are cytopathogenic, i.e. induce morphological changes in cultured mammalian cells. Toxin B, however, is active at very much lower concentrations than toxin A (Donta et al. 1982; Libby and Wilkins, 1982).


Tetanus Toxin Cellular Internalization Toxin Exposure Endocytotic Vesicle Lysosomotropic Agent 
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Copyright information

© Martinus Nijhoff Publishers, Boston 1984

Authors and Affiliations

  • Monica Thelestam
  • Inger Florin

There are no affiliations available

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