Abstract
Pigs which were vaccinated with an inactivated ADV vaccine developed a latent ADV infection up to 18 months after ADV challenge. Latent virus could be demonstrated up to 6.5 months post infection by co-cultivation of different tissues (lungs, tonsils, olfactory bulb, brain stem, medulla). After this time, reactivation of latent virus was only achieved by immunosuppresion of the animals. Immunosuppression led to limited virus replication in nasal mucosa, tonsils, lymph nodes and central nervous system. In addition, ADV was detected in the nasal secretions.
Humoral and cellular immunity was investigated before and after immunosuppression of the animals. Before immunosuppression most of the animals displayed spontaneous cell-mediated cytotoxicity (SCC), antibody-dependent cell-mediated cytotoxicity (ADV-ADCC) and ADV-specific lymphocyte stimulation (ADV-LYST), and all animals had medium to high titres of neutralizing serum antibodies. After immunosuppression the number of pigs reacting in SCC and ADV-LYST assays was distinctly reduced, but the number of animals reacting in ADV-ADCC assays remained unaltered. A significant reduction of serum antibody titres occurred only in 2 of 12 animals one day after the end of immunosuppression.
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© 1984 ECSC, EEC, EAEC, Brussels-Luxembourg
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Wittmann, G., Ohlinger, V., Rziha, H.J. (1984). Latency of Aujeszky’s Disease Virus (ADV) Following Challenge in Previously Vaccinated Pigs. In: Wittmann, G., Gaskell, R.M., Rziha, HJ. (eds) Latent Herpes Virus Infections in Veterinary Medicine. Current Topics in Veterinary Medicine and Animal Science, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5662-9_34
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DOI: https://doi.org/10.1007/978-94-009-5662-9_34
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