Abstract
Throughout this paper it would have been possible to make frequent reference to the characteristics of MCFV which are similar to or different from those of primate, rabbit and avian viruses which are now classed as Gammaherpesvirinae (Roizman et al., 1981), or lymphoproliferative herpesviruses (Epstein-Barr virus, H. saimiri, H. ateles, H. sylvilagus and Marek’s disease virus in particular). Such comparisons have undoubtedly been invaluable. We have been taken to task by Hunt and Billups (1979) for our failure to recognise MCF for what it is, comparatively speaking. This may seem a little difficult to accept as “African” MCFV was the first of the lymphoproliferative herpesviruses to be recognised (1960) and there is, unfortunately, no evidence that it induces neoplastic transformation of any cell in any species. The similarities of MCF to infectious mononucleosis were observed in 1953 (Plowright, 1953a,b) and rabbits have been used as an “experimental model” for nearly 50 years. Furthermore, MCF is still a clinicopathological and not an aetiological entity; until an identity of causal agents is proven it is important to recognise the possibility of differences between the wildebeest-derived and sheep-associated diseases; Hunt and Billups (1979) unfortunately took for pathological examination tissues from animals which were well-documented, sheep-associated cases (Piercy, 1954) and attributed to them a herpesvirus aetiology. It is to be hoped that this paper will clarify some of the issues involved.
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Plowright, W. (1984). Malignant Catarrhal Fever Virus: A Lymphotropic Herpesvirus of Ruminants. In: Wittmann, G., Gaskell, R.M., Rziha, HJ. (eds) Latent Herpes Virus Infections in Veterinary Medicine. Current Topics in Veterinary Medicine and Animal Science, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5662-9_23
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