Abstract
The susceptibility of juvenile and adult Tupaias to infection with herpes simplex virus (HSV) was investigated in detail. It was found that HSV type 1 and 2 were highly pathogenic for juvenile and adult Tupaias. The state of viral latency was studied using the co-cultivation technique in those animals which had survived an acute infection. Infectious virus was recovered from the ganglia of chronically infected tree shrews. The susceptibility of juvenile Tupaias to several strains of temperature-sensitive mutants of HSV type 1 and 2 was also investigated. These experiments revealed that the animals survived an infection of different ts-mutants of HSV 1 and 2 and were protected against a superinfection of a lethal dose of wild-type HSV-1 and/or 2. The state of viral latency in these surviving animals was studied. It was found that infectious virus could only be recovered from the spleen of these animals. Genomic analysis of these newly recovered viruses showed significant changes as compared to their parental viruses. This finding led to the development of a model system for the generation of intertypic recombinants in vivo.
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References
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© 1984 ECSC, EEC, EAEC, Brussels-Luxembourg
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Darai, G., Scholz, H.J. (1984). Latency of Herpes Simplex Virus in Tree Shrew; Generation of Intertypic Recombinants of Herpes Simplex Virus in Vivo. In: Wittmann, G., Gaskell, R.M., Rziha, HJ. (eds) Latent Herpes Virus Infections in Veterinary Medicine. Current Topics in Veterinary Medicine and Animal Science, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5662-9_2
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DOI: https://doi.org/10.1007/978-94-009-5662-9_2
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