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Congenital Hypothyroidism: Pathogenesis, Screening and Prognosis

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Paediatric Endocrinology in Clinical Practice

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Abstract

During the last two decades there have been great advances in our understanding of fetal and neonatal thyroid function. This information has played a vital role in the development of screening methods for congenital hypothyroidism and will be reviewed briefly before the pathogenesis and prognosis in congenital hypothyroidism are considered.

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References

  1. Fisher, D. A., Dussault, J. H., Sack, J. and Chopra, D. (1977). Ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in man, sheep and rat. Recent Prog. Horm. Res., 33, 59–116

    Google Scholar 

  2. Fisher, D. A. and Klein, A. H. (1981). Thyroid development and disorders of thyroid function in the newborn. N. Engl. J. Med., 304, 702–712

    CAS  Google Scholar 

  3. Cuestas, R. A. (1978). Thyroid function in healthy premature infants. J. Pediatr., 92, 963–967

    Article  PubMed  CAS  Google Scholar 

  4. Black, E. G., Bodden, S. J., Hulse, J. A. and Hoffenberg, R. (1982). Serum thyroglobulin in normal and hypothyroid neonates. Clin. Endocrinol., 16, 267–274

    Article  CAS  Google Scholar 

  5. Czernichow, P., Schlumberger, M., Pomarede, R. and Fragu, P. (1983). Plasma thyroglobulin measurements help determine the type of thyroid defect in congenital hypothyroidism. J. Clin. Endocrinol. Metab., 56, 242–245

    Article  PubMed  CAS  Google Scholar 

  6. Neinas, F. W., Gorman, C. A., Devine, K. D. and Woolner, L. B. (1973). Lingual thyroid: clinical characteristics of 15 cases. Ann. Int. Med., 79, 205–210

    Article  PubMed  CAS  Google Scholar 

  7. Orti, E., Castells, S., Qazi, Q. H. and Inamdar, S. (1971). Familial thyroid disease: lingual thyroid in two siblings and hypoplasia of a thyroid lobe in a third. J. Pediatr., 78, 671–677

    Article  Google Scholar 

  8. Kaplan, M., Kauli, R., Raviv, U., Lubin, E. and Laron, Z. (1977). Hypothyroidism due to ectopy in siblings. Am. J. Dis. Child., 131, 1264–1265

    PubMed  CAS  Google Scholar 

  9. Brown, A. L., Fernhoff, P. M., Milner J., McEwen, C. and Elsas, L. S. (1981). Racial differences in the incidence of congenital hypothyroidism. J. Pediatr., 99, 934–936

    Article  PubMed  CAS  Google Scholar 

  10. Iseki, M., Shimizu, M., Oikawa, T., Mojo, H., Arikawa, K., Ichikawa, Y., Moinotani, N. and Ito, K. (1983). Sequential serum measurements of thyrotropinbinding inhibitor immunoglobulin G in transient familial neonatal hypothyroidism. J. Clin. Endocrinol. Metab., 57, 384–387

    Article  PubMed  CAS  Google Scholar 

  11. Ritzen, E. M., Mahler, H. and Alveryd, A. (1981). Transitory congenital hypothyroidism and maternal thyroiditis. Acta Paediatr. Scand., 70, 765–766

    Article  PubMed  CAS  Google Scholar 

  12. Lyen, K. R., Finegold, D., Orsini, R., Herd, J. E. and Parks, J. S. (1982). Transient thyroid suppression associated with topically applied povidine-iodine. Am. J. Dis. Child., 136, 369–370

    PubMed  CAS  Google Scholar 

  13. Delange, F., Dodion, J., Wolter, R., Bourdoux, P., Dalhem, A., Glinoer, D. and Ermans, A-M. (1978). Transient hypothyroidism in the newborn infant. J. Pediatr., 92, 974–976

    Article  PubMed  CAS  Google Scholar 

  14. Lewis, P. D., Patel, A. J., Johnston, A. L. and Balazs, R. (1976). Effect of thyroid deficiency on cell acquisition in the postnatal rat brain: a quantitative histological study. Brain Res., 104, 49–62

    Article  PubMed  CAS  Google Scholar 

  15. Brasel, J. A. and Boyd, D. B. (1975). Influence of thyroid hormone on fetal brain growth and development. In Fisher, D. A. and Burrow, G. N. (eds.) Perinatal Thyroid Physiology and Disease, pp. 59–71. ( New York: Raven Press )

    Google Scholar 

  16. Eayrs, J. T. (1966). Thyroid and central nervous development. Sci. Basis Med. Ann. Rev., 317–339

    Google Scholar 

  17. Eayrs, J. T. (1971). Thyroid and developing brain: anatomical and behavioral effects. In Hamburgh, M. and Barrington, E. J. W. (eds.) Hormones in Development. pp. 345–55. ( New York: Appleton-Century-Crofts )

    Google Scholar 

  18. Smith, D. W., Blizzard, R. M. and Wilkins, L. (1957). The mental prognosis in hypothyroidism of infancy and childhood. Pediatrics, 19, 1011–1022

    PubMed  CAS  Google Scholar 

  19. Klein, A. H., Meltzer, S. and Kenny, F. M. (1972). Improved prognosis in congenital hypothyroidism treated before the age of three months. J. Pediatr., 81, 912–915

    Article  PubMed  CAS  Google Scholar 

  20. Raiti, S. and Newns, G. H. (1971). Cretinism: early diagnosis and its relation to mental prognosis. Arch. Dis. Child., 46, 692–694

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  21. Warne, G. L., Andrews, J. T., McKay, W. J. and Wettenhall, H. N. B. (1978). 99mTc Pertechnetate for detection of ectopic dysgenesis of the thyroid in childhood hypothyroidism. Aust. Paediatr. J., 14, 11–15

    Google Scholar 

  22. Money, J., Clarke, F. C. and Beck, J. (1978). Congenital hypothyroidism and IQ, increase: a quarter-century follow-up. J. Pediatr., 93, 432–434

    Article  PubMed  CAS  Google Scholar 

  23. Hulse, J. A. (1982). The place of screening for congenital hypothyroidism in the prevention of handicap. MD Thesis, University of Cambridge

    Google Scholar 

  24. Mäenpää, J. (1972). Congenital hypothyroidism: aetiological and clinical aspects. Arch. Dis. Child., 47, 914–923

    Article  PubMed  PubMed Central  Google Scholar 

  25. McFaul, R., Dorner, S., Brett, E. M. and Grant, D. B. (1978). Neurological abnormalities in patients treated for hypothyroidism from early life. Arch. Dis. Child., 53, 611–619

    Article  Google Scholar 

  26. Wolter, R., Noel, P., De Cock, P., Craen, M., Ernould, C. H., Malvaux, P., Verstraeten, F., Simons, J., Mertens, S., Van Broeck, N. and Vanderschueren-Lodewyckx, M. (1979). Neuropsychological study in treated thyroid dysgenesis. Acta Paediatr. Scand. Suppl., 277, 41–46

    Article  PubMed  CAS  Google Scholar 

  27. Burt, L. and Kulin, H. E. (1977). Head circumference in children with short stature secondary to primary hypothyroidism. Pediatrics, 59, 628–630

    PubMed  CAS  Google Scholar 

  28. Weldon, A. P. and Danks, D. M. (1972). Congenital hypothyroidism and neonatal jaundice. Arch. Dis. Child., 47, 469–471

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  29. Larsson, A., Hagenfeldt, L., Blom, L. and Mortensson, W. (1983). Serum alpha-fetoprotein — a biochemical indicator of prenatal hypothyroidism. Acta Paediatr. Scand., 72, 481–484

    Article  CAS  Google Scholar 

  30. Klein, A. H., Agustin, A. V. and Foley, T. P. (1974). Successful laboratory screening for congenital hypothyroidism. Lancet, 2, 77–79

    Article  PubMed  CAS  Google Scholar 

  31. Dussault, J. H., Coulombe, P., Laberge, C., Letarte, J., Guyda, H. and Khoury, K. (1975). Preliminary report on a mass screening program for neonatal hypothyroidism. J. Pediatr., 86, 670–674

    Article  PubMed  CAS  Google Scholar 

  32. Irie, M., Enomoto, K. and Naruse, H. (1975). Measurement of TSH in dried blood spots. Lancet, 2, 1233–1234

    Article  PubMed  CAS  Google Scholar 

  33. Fisher, D. A., Dussault, J. H., Foley, T. P., Klein, A. H., LaFrachni, S, Larsen, P. R., Mitchell, M. L., Murphy, W. H. and Walfish, P. G. (1979). Screening for congenital hypothyroidism: results of screening one million North American infants. J. Pediatr., 94, 704–705

    Article  Google Scholar 

  34. Illig, R. (1983). Report on neonatal thyroid screening in Europe. In Proceedings of the 22nd Annual Meeting of the European Society for Paediatric Endocrinology, Budapest, 1983

    Google Scholar 

  35. Dussault, J. H., Parlow, A., Letarte, J., Guyda, H. and Laberge, C. (1976). TSH measurements from blood spots on filter paper. A confirmatory screening test for congenital hypothyroidism. J. Pediatr., 89, 550–552

    Article  PubMed  CAS  Google Scholar 

  36. Alm, J., Larsson, A. and Zetterström, R. (1978). Congenital hypothyroidism in Sweden: incidence and age at diagnosis. Acta Paediatr. Scand., 67, 1–3

    Article  CAS  Google Scholar 

  37. Brock–Jacobsen, B. and Brandt, N. J. (1981). Congenital hypothyroidism in Denmark. Arch. Dis. Child., 56, 134–136

    Article  Google Scholar 

  38. DeJonge, G. A. (1976). Congenital hypothyroidism in the Netherlands. Lancet, 2, 143

    Article  CAS  Google Scholar 

  39. Hulse, J. A., Grant, D. B., Clayton, B. E., Lilly, P. Jackson, D., Spracklan, A., Edwards, R. W. H. and Nurse, D. (1980). Population screening for congenital hypothyroidism. Br. Med. J., 1, 675–678

    Article  Google Scholar 

  40. New England Congenital Hypothyroidism Collaborative (1982). Pitfalls in screening for neonatal hypothyroidism. Pediatrics, 70, 16–20

    Google Scholar 

  41. Hulse, J. A., Grant, D. B., Jackson, D. and Clayton, B. E. (1982). Growth, development and reassessment of hypothyroid infants diagnosed by screening. Br. Med. J., 1, 1435–1437

    Article  Google Scholar 

  42. Glorieux, J., Dussault, J. H., Letarte, J., Guyda, M. and Morisette, J. (1983). Preliminary results on the mental development of hypothyroid infants detected by the Quebec Screening Program. J. Pediatr., 102, 19–22

    Article  PubMed  CAS  Google Scholar 

  43. New England Congenital Hypothyroidism Collaborative (1981). Effects of neonatal screening for hypothyroidism: prevention of mental retardation by treatment before clinical manifestations. Lancet, 2, 1095–1098

    Google Scholar 

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Authors
  1. D. B. Grant
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Editors and Affiliations

  1. James Spence Professor of Child Health, The Children’s Clinic, Royal Victoria Infirmary, Newcastle upon Tyne, England

    A. Aynsley-Green

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© 1984 MTP Press Limited

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Grant, D.B. (1984). Congenital Hypothyroidism: Pathogenesis, Screening and Prognosis. In: Aynsley-Green, A. (eds) Paediatric Endocrinology in Clinical Practice. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5610-0_3

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  • DOI: https://doi.org/10.1007/978-94-009-5610-0_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8974-6

  • Online ISBN: 978-94-009-5610-0

  • eBook Packages: Springer Book Archive

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