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Physicochemical aspects of cholesterol gallstone formation

  • G. Salvioli
  • R. Lugli
  • J. M. Pradelli

Abstract

Formation of cholesterol gallstones is a non-biological event caused by changes in the chemical and physical properties of bile which lead to formation of a normally absent solid phase1.

Keywords

Bile Salt Ursodeoxycholic Acid Gallstone Disease Gallstone Formation Cholesterol Gallstone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Admirand, W. H. and Small, D. M. (1968). The physical-chemical basis of cholesterol gallstone formation in man. J. Clin. Invest., 47, 1043–1052PubMedCrossRefGoogle Scholar
  2. 2.
    Been, J. M., Bills, P. M. and Lewis, D. (1974). Microstructure of gallstones. Gastroenterology, 76, 548–555Google Scholar
  3. 3.
    Carey, M. C. and Small, D. M. (19 78). The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man. J. Clin. Invest., 61, 998–1026PubMedCrossRefGoogle Scholar
  4. 4.
    Hegardt, F. G. and Dam, H. (1974). The solubility of cholesterol in aqueous solution of bile salts and lecithin. Zeit. Ernaehrungswiss., 10, 228–233Google Scholar
  5. 5.
    Holzbach, R. T., Marsh, M., Olszewski, M. and Holan, K. (1973). Cholesterol solubility in bile. Evidence that supersaturated bile is frequent in healthy man. J. Clin. Invest., 52, 1467–1479PubMedCrossRefGoogle Scholar
  6. 6.
    Carey, M. C. (1978). Critical tables for calculating the cholesterol saturation of native bile. J. Lipid Res., 19, 945–955PubMedGoogle Scholar
  7. 7.
    Van der Linden, W. and Nakayama, F. (19 74). Occurrence of cholesterol crystals in human bile. Gut, 15, 630–635PubMedCrossRefGoogle Scholar
  8. 8.
    Olszewski, M. F., Holzbach, R. T., Saupe, A. and Brown, G. H. (1973). Liquid crystals in human bile. Nature, 242, 336–337PubMedCrossRefGoogle Scholar
  9. 9.
    Somjen, G. J. and Gilat, T. (1983). A non-micellar mode of cholesterol transport in human bile. FEBS Lett., 156, 265–268PubMedCrossRefGoogle Scholar
  10. 10.
    Sedaghat, A. and Grundy, S. M. (1980). Cholesterol crystals and the formation of cholesterol gallstones. N. Engl. J. Med., 302, 1224–1227CrossRefGoogle Scholar
  11. 11.
    Holzbach, R. T. and Corbusier, C. (1978). Liquid crystals and cholesterol nucleation during equilibration in supersaturated bile analogs. Biochim. Biophys. Acta, 528, 436–444PubMedGoogle Scholar
  12. 12.
    Mazer, N. A. and Carey, M. C. (1983). Quasi-elastic light-scattering studies of aqueous biliary lipid systems. Cholesterol solubilization and precipitation in model bile solutions. Biochemistry, 22, 426–142PubMedCrossRefGoogle Scholar
  13. 13.
    Gibbs, J. W. (1928). The Collected Works of J. Willard Gibbs. (New York: Longmans, Green and Co. )Google Scholar
  14. 14.
    Craven, B. M. (1976). Crystal structure of cholesterol monohydrate. Nature, 260, 727–729PubMedCrossRefGoogle Scholar
  15. 15.
    Small, D. M. (1980). Cholesterol nucleation and growth in gallstone formation. N. Engl. J. Med., 302, 1305–1307PubMedCrossRefGoogle Scholar
  16. 16.
    Toor, E. W., Evans, D. F. and Cussler, E. L. (1978). Cholesterol monohydrate growth in model bile solutions. Proc. Natl. Acad. Sci., 75, 6230–6234PubMedCrossRefGoogle Scholar
  17. 17.
    Holan, K. R., Holzbach, R. T., Hermann, R. E., Cooperman, A. M. and Claffey, W. J. (1979). Nucleation time: a key factor in the pathogenesis of cholesterol gallstone disease. Gastroenterology, 77, 611–617PubMedGoogle Scholar
  18. 18.
    Garside, J. (1982). Nucleation. In Nancollas, G. H. (ed.) Biological Mineralization and Demineralization. Dahlem Konferenzen, pp. 23–35. ( Berlin, Heidelberg, New York: Springer-Verlag )Google Scholar
  19. 19.
    Whiting, M. J. and Watts, J. McK. (1983). Cholesterol crystal formation and growth in model bile solutions. J. Lipid Res., 24, 861–868PubMedGoogle Scholar
  20. 20.
    Salvioli, G., Igimi, H. and Carey, M. C. (1983). Cholesterol gallstone dissolution in bile. Dissolution kinetics of crystalline cholesterol monohydrate by conjugated chenodeoxy-cholate-lecithin and conjugated urodeoxycholate-lecithin mixtures: dissimilar phase equilibria and dissolution mechanisms. J. Lipid Res., 24, 701–719PubMedGoogle Scholar
  21. 21.
    Gollish, S. H., Burnstein, M. J., Ilson, R. G., Petrunka, C. N. and Strasberg, S. M. (1983). Nucleation of cholesterol monohydrate crystals from hepatic and gallbladder bile of patients with cholesterol gallstones. Gut, 24, 836–844PubMedCrossRefGoogle Scholar
  22. 22.
    Burnstein, M. J., Ilson, R. G., Petrunka, C. N., Taylor, R. D. and Strasberg, S. M. (1983). Evidence for a potent nucleating factor in the gallbladder bile of patients with cholesterol gallstones. Gastroenterology, 85, 801–807PubMedGoogle Scholar
  23. 23.
    Gill, W. B., Ruggiero, K. J. and Fromes, M. C. (1980). Elevation of the metastable limits and absence of container surface nucleation for calcium Oxalate crystallization in a urothelial-lined system as compared to glass containers. Invest. Urol., 18, 157–161Google Scholar
  24. 24.
    Higuchi, W. I. and Saad, H. Y. (1965). Cholesterol particles growth and solution rates in aqueous media. J. Pharm. Sci., 54, 72–78Google Scholar
  25. 25.
    Ohara, M. and Reid, R. C. (1973). Modeling Crystal Growth Rates from Solutions. pp. 19–45. ( Englewood Cliffs, NJ: Prentice-Hall )Google Scholar
  26. 26.
    Sutor, D. J. and Wooley, S. E. (1973). The nature and incidence of gallstones containing calcium. Gut, 14, 215–220, IPubMedCrossRefGoogle Scholar
  27. 27.
    Been, J. M., Bills, P. M. and Lewis, D. (1978). Microstructure of gallstones. Gastroenterology, 76, 548–555Google Scholar
  28. 28.
    Boskey, A. L, Boyan Salyers, B. D., Burnstein, L. S. and Mandel, I. D. (1983). Lipids associated with mineralization of human submandibular gland sialoliths. Arch. Oral Biol., 26, 779–785CrossRefGoogle Scholar
  29. 29.
    Bogren, H. and Larsson, K. (1963). Crystalline components of biliary calculi. Scand. J. Clin. Lab. Invest., 15, 569–572PubMedCrossRefGoogle Scholar
  30. 30.
    Bateson, M. C., Bouchier, I. A. D. and Trash, D. B. (1981). Calcification of radiolucent gallstones during treatment with ursodeoxycholic acid. Br. Med. J., 283, 645CrossRefGoogle Scholar
  31. 31.
    Gleeson, D., Ruppin, D. C., Murphy, G. M. and Dowling, R. H. (1983). Second look at ursodeoxycholic acid (UDCA): high efficacy for partial but low efficacy for complete gallstone dissolution, and a high rate of acquired stone opacification. Gut, 24, A999 (abstract)Google Scholar
  32. 32.
    Maki, T., Matsushiro, T., Suzuki, N. and Nakamura, N. (1971). Role of sulfated glycoprotein in gallstone formation. Surg. Gynecol. Obstet., 132, 846–854PubMedGoogle Scholar
  33. 33.
    Womack, N. A. (1971). The development of gallstones. Surg. Gynecol. Obstet., 132, 37–45Google Scholar
  34. 34.
    Smith, B. F. and LaMont, J. T. (1983). Bovine gallbladder mucin binds bilirubin in vitro. Gastroenterology, 85, 707–712PubMedGoogle Scholar
  35. 35.
    Sutor, D. J. (1980). Ionized-calcium in pathological human bile. J. Clin. Pathol., 33, 86–88PubMedCrossRefGoogle Scholar
  36. 36.
    Mingrone, G., Greco, A. V. and Passi, S. (1983). The possible role of free fatty acids in the pathogenesis of cholesterol gallstones in man. Biochim. Biophys. Acta, 751, 138–144PubMedGoogle Scholar
  37. 37.
    Masuda, H. and Nakayama, F. (1979). Composition of bile pigment in gallstones and bile and their etiological significance. J. Lab. Clin. Med., 93, 353–360PubMedGoogle Scholar
  38. 38.
    Kawamoto, T., Kost, L.J., Sewell, R. B., Mao, S.J. T., Thistle, J. L. and LaRusso, N. F. (1982). Biliary excretion of the protein and lipid components of lipoproteins. Hepatology, 2, 699 (abstract)Google Scholar
  39. 39.
    King, M. (1980). Viscoelastic properties of airway mucus. Fed. Proc., 39, 3080–3085PubMedGoogle Scholar
  40. 40.
    Pearson, J. P., Kaura, R., Taylor, W. and Allen, A. (1983). The composition and polymeric structure of mucus glycoprotein from human gallbladder. Biochim. Biophys. Acta, 706, 221–228CrossRefGoogle Scholar
  41. 41.
    Bouchier, I. A. D., Copperband, S. R. and El Kidsl, B. M. (1965). Mucous substances and viscosity of normal and pathological human bile. Gastroenterology, 49, 343–352PubMedGoogle Scholar
  42. 42.
    Lee, S. P., LaMont, J. T. and Carey, M. C. (1981). Role of gallbladder mucus hypersecretion in the evaluation of cholesterol gallstones. J. Clin. Invest., 67, 1712–1723PubMedCrossRefGoogle Scholar
  43. 43.
    Schade, H. (1911). Zur Genese der Gallensteine. Z. Exp. Pathol. Ther., 8, 92–124CrossRefGoogle Scholar
  44. 44.
    Levy, P., Smith, B. F., Atkinson, D. and LaMont, J. T. (1983). Human gallbladder mucin enhances in vitro nucleation of cholesterol monohydrate crystals. Gastroenterology, 84, 1382 (abstract)Google Scholar
  45. 45.
    Allen, B., Bernhoft, R., Blanckaert, N., Svanvik, J., Filly, R., Gooding, G. and Way, L. (1981). Sludge is calcium bilirubinate associated with bile stasis. Am. J. Surg., 141, 51–54PubMedCrossRefGoogle Scholar
  46. 46.
    Pitt, H. A., King, W., Mann, L. L, Roslyn, J. J., Bequist, W. E., Ament, M. E. and DenBesten, L. (1983). Increased risk of cholelithiasis with prolonged total parenteral nutrition. Am. J. Surg., 145, 106–112PubMedCrossRefGoogle Scholar
  47. 47.
    Doty, J. E., Pitt, H. A., Kuchenbecker, S. L. and DenBesten, L. (1983). Impaired gallbladder emptying before gallstone formation in the prairie dog. Gastroenterology, 85, 168–174PubMedGoogle Scholar
  48. 48.
    Doty, J. E., Pitt, H. A., Kuchenbecker, S. L., Porter-Fink, V. and DenBesten, L. (1983). The role of gallbladder mucus in the pathogenesis of cholesterol gallstones. Am. J. Surg., 145, 54–61PubMedCrossRefGoogle Scholar
  49. 49.
    Hutton, S. W., Siewert, C. E. Jr., Vennes, J. A. and Duane, W. C. (1982). Inhibition of gallstone formation by sphincterotomy in the prairie dog: reversal by atropine. Gastroenterology, 82, 1308–1313PubMedGoogle Scholar
  50. 50.
    Martin, G. P., Marriott, C. and Kellaway, I. W. (1978). Direct effect of bile salts and phospholipids on the physical properties of mucus. Gut, 19, 103–107PubMedCrossRefGoogle Scholar
  51. 51.
    Tagesson, C., Norrby, S. and Sjödahl, R. (1979). The prerequisites for local lysolecithin formation in the human gallbladder. III: Demonstration of two different phospholipase A activities. Scand. J. Gastroenterol., 14, 379–384PubMedCrossRefGoogle Scholar

Copyright information

© MTP Press Limited 1984

Authors and Affiliations

  • G. Salvioli
  • R. Lugli
  • J. M. Pradelli

There are no affiliations available

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