Intestinal metabolism of bile acids and cholelithiasis

  • N. Carulli
  • P. Loria
  • D. Menozzi


In 1969 Cleave1 proposed the term ‘the saccharine disease’ to include diverse conditions associated with overconsumption, such as obesity, diabetes and coronary heart disease, or attributed to colonic stasis such as constipation, haemorrhoids and diverticulosis. In the author’s view such diseases share a common aetiological factor represented by the consumption of refined carbohydrates which has two effects: it increases the caloric intake/weight of ingested food ratio, and alters the colonic function due to the diminished ingestion of roughage, lost during the refining procedures.


Bile Acid Gallstone Disease Cholesterol Gallstone Lithocholic Acid Biliary Lipid 
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© MTP Press Limited 1984

Authors and Affiliations

  • N. Carulli
  • P. Loria
  • D. Menozzi

There are no affiliations available

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