Abstract
While conducting studies on the induction of ovulation in anovulation, and the stimulation of luteal function in luteal insufficiency, with the hyperpotent analog of LH-RH, we found that the LH-RH analog was effective in inhibiting the gonadal functions. We therefore started studies on the possible use of the analog in the termination of early pregnancy and to investigate its mechanism of action. As a trial agent, we used [des-gly10][pro9-ethylamide]-LH-RH or D-leu6-LH-RH-EA. Low levels of urinary hCG were measured by the Hi-Gonavis method.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Saito, M., Kumasaka, T., Yaoi, Y., Nishi, N., Arimura, A., Coy, D. H. and Schally, A. V. (1977). Stimulation of LH and FSH secretion by (d-leu6,des-gly10-NH2)-LH-RH-ethylamide after SC, Intravaginal and Intrarectal administration to women. Fertil. Steril., 28, 240–245
Yaoi, Y., Kumasaka, T., Nishi, N., Koyama, T., Ohkura, T., Saito, M., Arimura, A. and Scgally, S. V. (1976). Clinicial studies on Inducing Ovulation with [Des-Gly10][Pro9-ethylamide]-LH-RH, 5th International Congress of Endocrinology, Hamburg
Yaoi, Y., Kubota, T., Imakita, T., Suzuki, A., Nishi, N., Teh, A., Ohkura, T., Koyama, T., Nishi, N., Saito, M., Kumasaka, T. and Arimura, A. (1980). Study on Induction of Ovulation by LH-RH Analog, Xth International Congress of Fertility & Sterility. Madrid
Bergquist, C., Nillius, S. J. and Wide, L. (1982). Long-term intranasal luteinizing hormone-releasing hormone agonist treatment for contraception in women. Fertil. Steril., 38, 190–193
Yen S. S. C. (1983). Clinical applications of gonadotropin-releasing hormone and gonado-tropin-releasing hormone analogs. Fertil. Steril., 39, 257–266
Editor information
Rights and permissions
Copyright information
© 1984 MTP Press Limited
About this chapter
Cite this chapter
Yaoi, Y. et al. (1984). Study on the effect of LH-RH analog in the termination of pregnancy. In: Bonnar, J., Thompson, W., Harrison, R.F. (eds) Research in Family Planning. Studies in Fertility and Sterility, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5604-9_29
Download citation
DOI: https://doi.org/10.1007/978-94-009-5604-9_29
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8971-5
Online ISBN: 978-94-009-5604-9
eBook Packages: Springer Book Archive