Potential for prostaglandin use in controlling human reproduction
It was observed in 1930 that seminal plasma of a number of species contained very large amounts of substance(s) capable of altering uterine motility. These substances were subsequently demonstrated to be prostaglandins (PGs); this began the early and continued association of this group of compounds with reproduction. The activity was found to be associated with a fraction containing lipid–soluble acids, derived from prostanoic acid. Restrictions imposed by obscure sources and small amounts of material available for testing were initially impediments to their study. However, after some time and considerable effort, a cooperative venture by The Upjohn Company and scientists at the Karolinska Institute resulted in the isolation of compound in pure form from sheep vesicular glands. The structures of PGE1 and PGFlα were subsequently determined (Bergstrom et al., 1968; Bergstrom and Sjovall, 1957). Larger amounts of materials were then prepared which enabled biologists to investigate their properties more extensively in a number of tests.
KeywordsCorpus Luteum Seminal Plasma Arachidonic Acid Cascade Fertility Regulation Bovine Corpus Luteum
Unable to display preview. Download preview PDF.
- Granström, E. (1983). The Prostaglandins, thromboxanes and leukotrienes. In: The importance of Prostaglandins in obstetrics and gynecology. Acta Obstet. Gynecol. Scand., Suppl. 113, 9–14Google Scholar
- Greene, S. I. and Gilling, E. A. (1979). Postconceptional menses induction with a single dose of (15S)–15–methyl Prostaglandin F2α methyl ester in a silicone vaginal device. Acta Therapeutica, 5, 143–153Google Scholar
- Karim, S. M. M. (1975). Advances in Prostaglandin research. In Karim, S. M. M. (ed.). Prostaglandins and Reproduction. (Lancaster: MTP Press)Google Scholar
- Kimball, F. A. (1983). Role of PGI2 and other Prostaglandins in pregnancy. In Lewis, P. J., O’Grady, J. and Moncoda, S. (eds.). Prostacyclin and Pregnancy, pp. 1–13. (London: Raven Press)Google Scholar
- Kimball, F. A. and Kirton, K. T. (1977). Prostaglandins as antifertility agents. In Goldberg, M. E. (ed.). Pharmacological and Biochemical Properties of Drug Substances, pp. 373–386. (Washington, DC: American Pharmaceutical Association)Google Scholar
- Kirton, K. T., Kimball, F. A. and Porteus, S. E. (1976). Reproductive physiology: prostaglandin–associated events. In Paoletti, R. and Samuelsson, B. (eds.). Advances in Prostaglandin and Thromboxane Research, Vol. 2, pp. 621–625. (New York: Raven Press)Google Scholar
- Mackenzie, R. D. and Embrey, M. P. (1978). The influence of pre–induction vaginal Prostaglandin E2 gel upon subsequent labor. Br. J. Obstet. Gynaecol., 84, 657–661Google Scholar
- Pharriss, B. B. and Kirton, K. T. (1969). Prostaglandin F2α: a new contraceptive approach. Excerpta Med. Int. Congr., Ser No. 207, 2185Google Scholar
- Roseman, T. J., Spilman, C. H., Tuttle, M. E., Lee, E. K. L. and Lonsdale, H. K. (1982). Membrane controlled delivery of Prostaglandins. Contraceptive Deliv. Syst., 3, 460Google Scholar
- Samuelsson, B.. Granström, E., Gréen, K. and Hamberg, M. (1971). Metabolism of Prostaglandins. Ann. NY Acad. Sci., 180, 138–163Google Scholar
- Sharma, S. D., Hale, R. W. and Steinmiller, V. (1983). Intramuscular administration of 15(S)–15 methyl Prostaglandin F2α and olaminaria insertion for termination of mid trimester pregnancy. Contraceptive Deliv. Syst., 3, 477Google Scholar