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Male fertility control with an LHRH agonist: primate studies

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LHRH and Its Analogs

Part of the book series: Advances in Reproductive Health Care ((ARHE,volume 1))

Abstract

The pulsatile administration of LHRH, mimicking its endogenous pattern of release stimulates the pituitary–gonadal axis enhancing fertility (Carmel et al., 1976; Knobil, 1980; Wickings et al., 1981a). However, continuous administration of identical doses of LHRH or more potent agonists leads to pituitary desensitization and paradoxical antifertility effects (Be1chetz et al., 1978; Sandow et al., 1978). The initial hypersecretion of pituitary gonadotropins following high dose LHRH administration causes a down regulation of gonadal gonadotropin receptors. Chronic administration of LHRH agonists then leads to pituitary refractoriness. These effects are accompanied by decreased ovarian and testicular steroidogenesis which results in a regression of steroid dependent accessory reproductive organs.

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Authors
  1. F. Bint Akhtar
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  2. E. J. Wickings
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  3. E. Nieschlag
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Editor information

B. H. Vickery J. J. Nestor Jr. E. S. E. Hafez

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© 1984 MTP Press Limited

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Akhtar, F.B., Wickings, E.J., Nieschlag, E. (1984). Male fertility control with an LHRH agonist: primate studies. In: Vickery, B.H., Nestor, J.J., Hafez, E.S.E. (eds) LHRH and Its Analogs. Advances in Reproductive Health Care, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5588-2_7

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  • DOI: https://doi.org/10.1007/978-94-009-5588-2_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8963-0

  • Online ISBN: 978-94-009-5588-2

  • eBook Packages: Springer Book Archive

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