Abstract
The delivery of polypeptide and protein drugs by a convenient and effective method is a major challenge in the development of these compounds as therapeutic agents. Due to degradation and/or lack of absorption in the gastrointestinal tract, large, uneconomical doses are required for activity following oral administration. Rectal, nasal and depot injectable preparations have been investigated for the delivery of insulin but success has been limited. The injectable route, which assures availability of drug to the patient, is still the most frequently used. Efficient absorption and low variability of absorption are among the criteria to be emphasized when developing alternative delivery systems.
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Anik, S.T., Sanders, L.M., Chaplin, M.D., Kushinsky, S., Nerenberg, C. (1984). Delivery systems for LHRH and analogs. In: Vickery, B.H., Nestor, J.J., Hafez, E.S.E. (eds) LHRH and Its Analogs. Advances in Reproductive Health Care, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5588-2_33
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DOI: https://doi.org/10.1007/978-94-009-5588-2_33
Publisher Name: Springer, Dordrecht
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