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LHRH and analogs in relation to livestock

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LHRH and Its Analogs

Part of the book series: Advances in Reproductive Health Care ((ARHE,volume 1))

Abstract

Since its structural elucidation and synthesis, luteinizing hormone releasing hormone (LHRH) has been utilized extensively in most domestic species of livestock. On the other hand, evaluation of the in vivo effects of the LHRH analogs in these same species has been limited to only a few studies. The commercial availability of LHRH and its analogs and an increased awareness of how these peptide hormones can affect mammalian reproduction has prompted investigations into the utility of these preparations for large animal medicine. Application of these peptide hormones to the livestock industry involves both their profertility and antifertility properties.

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References

  • Al-Dahashn, S. Y. A. and David, J. S. E. (1977). Histological examination of ovaries and uteri from cows with cystic ovaries. Vet. Rec., 101, 342

    Article  Google Scholar 

  • Bierschwal, C. J., Garverick, H. A., Martin, C. E., Youngquist, R. S., Cantley, T. C. and Brown, M. D. (1975). Clinical response of dairy cows with ovarian cysts to GnRH. J. Anim. Sci., 41, 1660

    PubMed  CAS  Google Scholar 

  • Bremner, W. J., Findlay, J. K., Lee, V. W. K., deKretser, D. M. and Cumming, I. A. (1980). Feedback effects of the testis on pituitary responsiveness to luteinizing hormone-releasing hormone infusions in the ram. Endocrinology, 106, 329

    Article  PubMed  CAS  Google Scholar 

  • Britt, J. H., Kittok, R. J. and Harrison, D. S. (1974). Ovulation, estrus and endocrine response after GnRH in early postpartum cows. J. Anim. Sci., 39, 915

    PubMed  CAS  Google Scholar 

  • Brown, E. M., Elmore, R. G., Garverick, H. A. and Kesler, D. J. (1982). Gonadotropin releasing hormone treatment of dairy cows with ovarian cysts. II. Histology of ovarian cyst walls. Theriogenology, 17, 689

    Article  Google Scholar 

  • Cantley, T. C., Garverick, H. A., Bierschwal, C. J., Martin, C. E. and Youngquist, R. S. (1975). Hormonal response of dairy cows with ovarian cysts to GnRH. J. Anim. Sci., 41, 1666

    PubMed  CAS  Google Scholar 

  • Chipepa, J. A. S., Kinder, J. E. and Reeves, J. J. (1977). Synchronized breeding in cattle using PGF2α and LHRH/FSHRH stimulatory analogs. Theriogenology, 8, 25

    Article  CAS  Google Scholar 

  • Clarke, I. J., Fraser, H. M. and McNeilly, A. S. (1978). Active immunization of ewes against luteinizing hormone releasing hormone and its effects on ovulation and gonadotrophin, prolactin and ovarian steroid secretion. J. Endocrinol., 78, 39

    Article  PubMed  CAS  Google Scholar 

  • Domanski, E. and Kochman, K. (1968). Induction of ovulation in sheep by intraadenohypophysial infusion of hypothalamic extracts. J. Endocrinol., 42, 383

    Article  PubMed  CAS  Google Scholar 

  • English, H. F., Schanbacher, B. D., Gross, D., Walker, M. F., Falvo, R. E. and Santen, R. J. (1983). Animal model of isolated gonadotropin deficiency: II. Morphological responses to LHRH immunoneutralization. J. Androl., 4, 240

    PubMed  CAS  Google Scholar 

  • Foster, D. L., Mickelson, I. H., Ryan, K. D., Coon, G. A., Drongowski, R. A. and Holt, J. A. (1978). Ontogeny of pulsatile luteinizing hormone and testosterone secretion in male lambs. Endocrinology, 102, 1137

    Article  PubMed  CAS  Google Scholar 

  • Frandle, K. A., Kinder, J. E., Coy, D. H., Schally, A. V., Reeves, J. J. and Estergreen, V. L. (1977). Plasma progestins in anestrous ewes treated with d-Leu6 desGlyNH 102 -LHRH ethylamide. J. Anim. Sci., 45, 486

    CAS  Google Scholar 

  • Fraser, H. M. (1975). Effects of antibodies to luteinizing hormone releasing hormone on reproductive functions in rodents. In Nieschlag, E. (ed.) Immunization with Hormones in Reproduction Research, pp. 107–116. (Amsterdam: North Holland)

    Google Scholar 

  • Fraser, H. M. and Sandow, J. (1977). Gonadotrophin release by a highly active analogue of luteinizing hormone releasing hormone in rats immunized against luteinizing hormone releasing hormone. J. Endocrinol, 74, 291

    Article  PubMed  CAS  Google Scholar 

  • Garverick, H. A., Elmore, R. G., Vaillancourt, D. H. and Sharp, A. J. (1980). Ovarian response to gonadotropin-releasing hormone in postpartum dairy cows. Am. J. Vet. Res., 41, 1582

    PubMed  CAS  Google Scholar 

  • Gordon, I. (1963). The induction of pregnancy in the anoestrous ewe, by hormonal therapy. J. Agric. Sci. Camb., 60, 77

    Article  Google Scholar 

  • Greger, D. L., Stricklin, W. R., Haaland, M. A., Vickery, B. H. and Kushinsky, S. (1984). Reduction of boar taint steroid (5α-androst-16-en-3-one) and testosterone in serum of boars treated with an LHRH agonist. Submitted for publication

    Google Scholar 

  • Hackett, A. J. and Wolynetz, M. S. (1982). Reproductive performance of confined sheep in an accelerated controlled program under two lighting regimes. Theriogenology, 18, 621

    Article  Google Scholar 

  • Haynes, N. B., Hafs, H. D. and Manns, J. G. (1977). Effect of chronic administration of gonadotrophin releasing hormone and thyrotrophin releasing hormone to pubertal bulls on plasma luteinizing hormone, prolactin and testosterone concentration, the number of epididymal sperm and body weight. J. Endocrinol., 73, 227

    Article  PubMed  CAS  Google Scholar 

  • Haynes, N. B. and Schanbacher, B. D. (1983). The control of reproductive activity in the ram. In Haresign, W. (ed.) Sheep Production, pp. 441–465. (London: Butterworth)

    Google Scholar 

  • Hernandez-Ledezma, J. J., Garverick, H. A., Elmore, R. G., Brown, E. M. and Kesler, D. J. (1982). Gonadotropin releasing hormone treatment of dairy cows with ovarian cysts. III. Steroids in ovarian follicular fluid and ovarian cyst fluid. Theriogenology, 17, 697

    Article  CAS  Google Scholar 

  • Herschler, R. C. and Vickery, B. H. (1981). Effects of (d-Trp6-Des Gly10-Pro NH 92 )-Luteinizing hormone-releasing hormone ethylamide on the estrous cycle, weight gain, and feed efficiency in feedlot heifers. Am. J. Vet. Res., 42, 1405

    PubMed  CAS  Google Scholar 

  • Hodges, J. K. and Hearn, J. P. (1977). Effects of immunization against luteinizing hormone releasing hormone on reproduction of the marmoset monkey (Callithrix jacchus). Nature (Lond.), 265, 747

    Article  Google Scholar 

  • Jeffcoate, I. A., Foster, J. P. and Crighton, D. B. (1978). Effect of active immunization of ewes against synthetic luteinizing hormone releasing hormone. Theriogenology, 10, 323

    Article  PubMed  CAS  Google Scholar 

  • Jeffcoate, I. A., Lucas, J. M. S. and Crighton, D. B. (1982). Effects of active immunization of ram lambs and bull calves against synthetic luteinizing hormone releasing hormone. Theoriogenology, 18, 65

    Article  CAS  Google Scholar 

  • Johnson, E. S., Gendrich, R. L. and White, W. F. (1976). Delay of puberty and inhibition of reproductive processes in the rat by a gonadotrophin releasing hormone agonist analog. Fertil. Steril., 27, 853

    PubMed  CAS  Google Scholar 

  • Karsch, F. J., Goodman, R. L. and Legan, S. J. (1980). Feedback basis of seasonal breeding: test of an hypothesis. J. Reprod. Fertil., 58, 521

    Article  PubMed  CAS  Google Scholar 

  • Kesler, D. J., Elmore, R. G., Brown, E. M. and Garverick, H. A. (1981). Gonadotropin releasing hormone treatment of dairy cows with ovarian cysts. I. Gross ovarian morphology and endocrinology. Theriogenology, 16, 207

    Article  PubMed  CAS  Google Scholar 

  • Kinder, J. E., Adams, T. E., Nett, T. M., Coy, D. H., Schally, A. V. and Reeves, J. J. (1976). Serum gonadotropin concentrations and ovarian response in ewes treated with analogs to LH-RH/FSH-RH. J. Anim. Sci., 42, 1220

    PubMed  CAS  Google Scholar 

  • Kittok, R. J., Britt, J. H. and Convey, E. M. (1973). Endocrine response after GnRH in luteal phase cows and cows with ovarian follicular cysts. J. Anim. Sci., 37, 985

    PubMed  CAS  Google Scholar 

  • Lacroix, A. and Pelletier, J. (1979). LH and testosterone release in developing bulls following LH-RH treatment. Effect of gonadectomy and chronic testosterone propionate pre-treatment. Acta Endocrinol., 91, 719

    PubMed  CAS  Google Scholar 

  • Lincoln, G. A. and Short, R. V. (1980). Seasonal breeding: Nature’s contraceptive. Recent Prog. Horm. Res., 36, 1

    PubMed  CAS  Google Scholar 

  • Lofstedt, R. M., Manns, J. G., Murphy, B. D., Humphrey, W. D. and Mapletoft, R. J. (1981). Influence of GnRH infusion on endocrine parameters and duration of postpartum anestrus in beef cows. Theriogenology, 15, 359

    Article  PubMed  CAS  Google Scholar 

  • McLeod, B. J. (1982). Plasma luteinizing hormone and ovarian follicle development in the ewe. Ph D Thesis, University of Nottingham

    Google Scholar 

  • McNatty, K. P., Gibb, M., Dobson, C. and Thurley, D. C. (1981). Evidence that changes in tonic luteinizing hormone secretion regulate the growth of the preovulatory follicle in the ewe. J. Endocrinol., 90, 375

    Article  PubMed  CAS  Google Scholar 

  • McNatty, K. P., Ball, K., Gibb, M., Hudson, N. and Thurley, D. C. (1982). Induction of cyclic ovarian activity in seasonally anoestrous ewes with exogenous GnRH. J. Reprod. Fertil., 64, 93

    Article  PubMed  CAS  Google Scholar 

  • Mayar, M. Q., Tarnavsky, G. K. and Reeves, J. J. (1978). Pituitary responsiveness following infusion or repeated injections of [d-Leu6, des Gly -NH 102 ]-LHRH-ethylamide in prepubertal ewes. J. Anim. Sci., 47, 235

    PubMed  CAS  Google Scholar 

  • Moger, W. H. (1982). Impact of pulsatile administration of gonadotropin-releasing hormone on the pituitary-testicular axis of the immature rat. J. Androl., 3, 256

    CAS  Google Scholar 

  • Reeves, J. J., Séguin, C., Lefebvre, F. A., Kelly, P. A. and Labrie, F. (1980). Similar LHRH binding sites in the rat anterior pituitary and ovary. Proc. Natl. Acad. Sci. USA, 77, 5567

    Article  PubMed  CAS  Google Scholar 

  • Riley, G. M., Peters, A. R. and Lamming, G. E. (1981). Induction of pulsatile LH release, FSH release and ovulation in postpartum acyclic beef cows by repeated small doses of Gn-RH. J. Reprod. Fertil., 63, 559

    Article  PubMed  CAS  Google Scholar 

  • Rippel, R. H., Johnson, E. S., White, W. F., Fujino, M., Fukuda, T. and Kobayashi, S. (1975). Ovulation and gonadotropin-releasing activity of [d-Leu6, Des GlyNH 102 , Pro-Ethylamide9]-GnRH. Proc. Soc. Exp. Biol. Med., 148, 1193

    PubMed  CAS  Google Scholar 

  • Robertson, I. S., Wilson, J. C. and Fraser, H. M. (1979). Immunological castration in male cattle. Vet. Rec., 105, 556

    Article  PubMed  CAS  Google Scholar 

  • Sandow, J., von Rechenberg, W. V., Konig, W., Hahn, M., Jerzabek, G. and Fraser, H. (1978). Physiological studies with highly active analogues of LHRH. In Gupta, D. and Voelter, W. (eds.) Hypothalamic Hormones - Chemistry, Physiology and Clinical Applications, pp. 307–326. (Weinheim: Verlag Chimie)

    Google Scholar 

  • Schanbacher, B. D. (1979). Increased lamb production with rams exposed to short daylengths during the nonbreeding season. J. Anim. Sci., 49, 927

    Google Scholar 

  • Schanbacher, B. D. (1981). Importance of the episodic nature of luteinizing hormone secretion for normal development of the bovine testis during puberty: Interference with oestradiol-17β. J. Endocr., 88, 393

    Article  PubMed  CAS  Google Scholar 

  • Schanbacher, B. D. (1982a). Hormonal interrelationships between hypothalamus, pituitary and testis of rams and bulls. J. Anim. Sci. (Suppl. II) 55, 56

    PubMed  Google Scholar 

  • Schanbacher, B. D. (1982b). Response of ram lambs to active immunization against testosterone and luteinizing hormone-releasing hormone. Am. J. Physiol., 242, E201

    PubMed  CAS  Google Scholar 

  • Schanbacher, B. D., D’Occhio, M. J. and Kinder, J. E. (1982). Initiation of spermatogenesis and testicular growth in oestradiol-17β-implanted bull calves with pulsatile infusion of luteinizing hormone releasing hormone. J. Endocrinol., 93, 183

    Article  PubMed  CAS  Google Scholar 

  • Schanbacher, B. D., English, H. F., Gross, D., Santen, R. J., Walker, M. F. and Falvo, R. E. (1983). Animal model of isolated gonadotropin deficiency: I. Hormonal responses to LHRH immunoneutralization. J. Androl., 4, 233

    PubMed  CAS  Google Scholar 

  • Séguin, C., Bélanger, A., Cusan, L., Pelletier, G., Reeves, J.J., Lefebvre, F.-A., Kelly, P. A. and Labrie, F. (1981). Relative importance of the adenohypophyseal and gonadal sites of inhibitory action of LHRH agonists. Biol. Reprod., 24, 889

    Article  PubMed  Google Scholar 

  • Short, R. V. (1962). Steroid concentrations in normal follicular fluid and ovarian cyst fluid from cows. J. Reprod. Fertil., 4, 27

    Article  PubMed  CAS  Google Scholar 

  • Vickery, B. H. (1982). Antigonadotropic, antisteroidogenic and antisteroidal activities of agonist analogs of luteinizing hormone-releasing hormone as revealed by their antireproductive activities. In Agarwal, M. K.(ed.) Hormone Antagonists, pp. 623–657. (Berlin: de Gruyter)

    Google Scholar 

  • Vickery, B. H. and McRae, G. I. (1980). Synchronization of oestrus in adult female rats by utilizing the paradoxical effects of an LH-RH agonist. J. Reprod. Fertil., 60, 399

    Article  PubMed  CAS  Google Scholar 

  • Walters, D. L., Short, R. E., Convey, E. M., Staigmiller, R. B., Dunn, T. G. and Kaltenback, C. C. (1982). Pituitary and ovarian function in postpartum beef cows. III. Induction of estrus, ovulation and luteal function with intermittent small-dose injections of GnRH. Biol. Reprod., 26, 655

    Article  PubMed  CAS  Google Scholar 

  • Wetteman, R. P., Turman, E. J., Wyatt, R. D. and Totusek, R. (1978). Influence of suckling intensity on reproductive performance of range cows. J. Anim. Sci., 47, 342

    Google Scholar 

  • Wheaton, J. E. and Mullett, M. A. (1982). Effects of progesterone treatment on basal and LH-RH-induced plasma LH concentrations in anoestrous and ovariectomized sheep. J. Reprod. Fertil., 64, 325

    Article  PubMed  CAS  Google Scholar 

  • Wildt, L., Marshall, G. and Knobil, E. (1980). Experimental induction of puberty in the infantile rhesus monkey. Science, 207, 1373

    PubMed  CAS  Google Scholar 

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  1. B. D. Schanbacher
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B. H. Vickery J. J. Nestor Jr. E. S. E. Hafez

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© 1984 MTP Press Limited

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Schanbacher, B.D. (1984). LHRH and analogs in relation to livestock. In: Vickery, B.H., Nestor, J.J., Hafez, E.S.E. (eds) LHRH and Its Analogs. Advances in Reproductive Health Care, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5588-2_30

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  • DOI: https://doi.org/10.1007/978-94-009-5588-2_30

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8963-0

  • Online ISBN: 978-94-009-5588-2

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