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Actions of LHRH and its analogs in lower vertebrates

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LHRH and Its Analogs

Part of the book series: Advances in Reproductive Health Care ((ARHE,volume 1))

Abstract

Pituitary gonadotropic hormone function in lower vertebrates is under stimulatory control by the brain (Ball, 1981). Gonadal regression results from the isolation or the removal of specific neurosecretory brain centres in reptiles, amphibians and fish. Extracts of both fish and sheep hypothalamus increase gonadotropin release from mature carp pituitaries incubated in vitro (Breton et al., 1972). Injections of synthetic LHRH into carp and trout increase circulating gonadotropin levels (Breton and Weil, 1973; Crim and Cluett, 1974). The high doses of LHRH required to elicit gonadotropin release from the fish pituitary lead to speculation that the structures of mammalian and fish LHRH are different.

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References

  • Anon (Conference on Application of Hormones to Economic Fish) (1975). Kexue Tonghoe, 20, 43 (Fishery Marine Service Translation Series No. 4186)

    Google Scholar 

  • Anon (The Fukien-Kiangsu-Chekiang-Shanghai Cooperative Group for Artificial Reproduction of Freshwater Economic Fishes) (1977a). A further investigation on the stimulatory effect of a synthetic analogue of hypothalamic luteinizing hormone releasing hormone (LRH-A) on spawning in ‘Domestic Fishes’. Acta Biochem. Biophys. Sinica, 9, 12

    Google Scholar 

  • Anon (Cooperative Team for Hormonal Application in Pisciculture) (1977b). A new highly effective ovulating agent for fish reproduction. Practical application of LH-RH analogue for the induction of spawning of farm fishes. Sci. Sinica., 20, 469

    Google Scholar 

  • Ball, J. N. (1981). Hypothalamic control of the pars distalis in fishes, amphibians and reptiles. Gen. Comp. Endocrinol., 44, 135

    Article  PubMed  CAS  Google Scholar 

  • Bao, I. Y. and Kallman, K. D. (1982). Genetic control of the hypothalamo-pituitary axis and the effect of hybridization on sexual maturation (Xiphophorus, Pisces, Poeciliidae). J. Exp. Zool., 220, 297

    Article  CAS  Google Scholar 

  • Barnett, F. H., Jackson, I. M. D., Sohn, J. and Reichlin, S. (1979). Novel large molecular weight luteinizing hormone releasing hormone in teleost fish brain. Endocrinology, 104, 148A

    Article  Google Scholar 

  • Barnett, F. H., Sohn, J., Reichlin, S. and Jackson, I. M. D. (1982). Three luteinizing hormone-releasing hormone like substances in a teleost fish brain: none identical with the mammalian LH-RH decapeptide. Biochem. Biophys. Res. Commun., 105, 209

    Article  PubMed  CAS  Google Scholar 

  • Billard, R., Marcel, J., Matéi, D. and Rusu, C. (1984). Induction de l’ovulation par un analogue du LH-RH chez Hypophthalmichthys molitrix (Poisson Téléostéen) placé dans diverses conditions d’environnement. Bull. Cere. Pise (Romania), (In press)

    Google Scholar 

  • Breton, B., Weil, C., Jalabert, B. and Billard, R. (1972). Activité réciproque des facteurs hypothalamiques de bélier (Ovis aries) et de poissons téléostéen sur la sécrétion in vitro des hormones gonadotropes G-HG et LH respectivement par les hypophyses de carpe et de bélier. C.R. Acad. Sci. Ser. D., 274, 2530

    CAS  Google Scholar 

  • Breton, B. and Weil, C. (1973). Effets du LH/FSH-RH synthétique et d’extraits hypothalamiques de carpe sur la sécrétion d’hormone gonadotrope in vivo chez la carpe (Cyprinus carpio L.). C.R. Acad. Sci. Ser. D., 277, 2061

    CAS  Google Scholar 

  • Breton, B., Jalabert, B. and Weil, C. (1975). Characterisation partielle d’un facteur hypothalamique de libération des hormones gonadotropes chez la carpe (Cyprinus carpio L.). Etude in vitro. Gen. Comp. Endocrinol., 25, 405

    Article  PubMed  CAS  Google Scholar 

  • Breton, B., Jalabert, B., Bieniarz, I., Sokolowska, M. and Epler, P. (1984). The effects of synthetic LH-RH and analog (D6 Serine Ethylamide 10 Gn-RH) on gonadotropin plasma levels, and oocyte sensitization to 17α-Hydroxy-20β-Dihydroprogesterone induced vesicle germinal breakdown. Aquaculture (In press)

    Google Scholar 

  • Chan, K. S. K. (1977). Effect of synthetic luteinizing hormone-releasing hormone (LH-RH) on ovarian development in Japanese medaka, Oryzias latipes. Can. J. Zool., 55, 155

    Article  CAS  Google Scholar 

  • Chang, J. P. and Peter, R. E. (1983a). Effects of dopamine on gonadotropin release in female goldfish, Carassius auratus. Neuroendocrinology, 36, 351

    Article  PubMed  CAS  Google Scholar 

  • Chang, J. P. and Peter, R. E. (1983b). Effects of pimozide and des-Gly10,[d-ala6] luteinizing hormone-releasing hormone ethylamide on serum gonadotropin concentrations, germinal vesicle migration and ovulation in female goldfish, Carassius auratus. Gen. Comp. Endocrinol. 52, 30

    Article  PubMed  CAS  Google Scholar 

  • Crim, L. W. and Cluett, D. M. (1974). Elevation of plasma gonadotropin concentration in response to mammalian gonadotropin releasing hormone (GRH) treatment of the male brown trout as determined by radioimmunoassay. Endocr. Res. Commun., 1, 101

    PubMed  CAS  Google Scholar 

  • Crim, L. W. and Evans, D. M. (1980). LH-RH stimulated gonadotropin release from the rainbow trout pituitary gland: An in vitro assay for detection of teleostean gonadotropin releasing factor(s). Gen. Comp. Endocrinol., 40, 283

    Article  PubMed  CAS  Google Scholar 

  • Crim, L. W. and Evans, D. M. (1983). Influence of testosterone and/or luteinizing hormone releasing hormone analogue on precocious sexual development in the juvenile rainbow trout. Biol. Reprod., 29, 137

    Article  PubMed  CAS  Google Scholar 

  • Crim, L. W., Evans, D. M., Coy, D. H. and Schally, A. V. (1981). Control of gonadotropic hormone release in trout: influence of synthetic LH-RH and LH-RH analogues in vivo and in vitro. Life Sci., 28, 129

    Article  PubMed  CAS  Google Scholar 

  • Crim, L. W., Evans, D. M. and Vickery, B. H. (1983a). Manipulation of the seasonal reproductive cycle of the landlocked salmon (Salmo salar) by LHRH analogues administered at various stages of gonadal development. Can. J. Fish. Aquat. Sci., 40, 61

    Article  CAS  Google Scholar 

  • Crim, L. W., Sutterlin, A. M., Evans, D. M. and Weil, C. (1983b). Accelerated ovulation by pelleted LHRH analogue treatment of spring-spawning rainbow trout (Salmo gairdneri) held at low temperature. Aquaculture, 35, 299

    Article  CAS  Google Scholar 

  • Daniels, E. and Licht, P. (1980). Effects of gonadotropin-releasing hormone on the levels of plasma gonadotropins (FSH and LH) in the bullfrog, Ram catesbeiana. Gen. Comp. Endocrinol., 42, 455

    Article  PubMed  CAS  Google Scholar 

  • Deery, D. J. and Jones, A. C. (1975). Effects of hypothalamic extracts, neurotransmitters and synthetic hypothalamic releasing hormones on the adenyl cyclase activity of the pituitary of the dogfish (Scyliorhinus canicula L.). J. Endocrinol., 64, 49

    Article  PubMed  CAS  Google Scholar 

  • De Vlaming, V. L. and Vodicnik, M. J. (1975). Effects of photoperiod-temperature regimes on pituitary gonadotrophs, pituitary gonadotropin potency and hypothalamic gonadotropin releasing activity in the teleost Notemigonus crysoleucas. J. Thermal Biol., 1, 119

    Article  Google Scholar 

  • Donaldson, E. M., Hunter, G. A. and Dye, H. M. (1981). Induced ovulation in coho salmon (Oncorhynchus kisutch). II. Preliminary study of the use of LH-RH and two high potency LHRH analogues. Aquaculture, 26, 129

    Article  CAS  Google Scholar 

  • Eiden, L. E. and Eskay, R. L. (1980). Characterization of LRF-like immunoreactivity in the frog sympathetic ganglia: non-identity with LRH decapeptide. Neuropeptides, 1, 29

    Article  CAS  Google Scholar 

  • Harvey, B. J. and Hoar, W. S. (1979). The Theory and Practice of Induced Breeding in Fish. (Ottawa: The International Development Research Centre)

    Google Scholar 

  • Hirose, K. and Ishida, R. (1974). Induction of ovulation in the ayu, Plecoglossus altivelis and LH-releasing hormone (LH-RH). Bull. Jpn. Soc. Sci. Fish., 40, 1235

    Article  CAS  Google Scholar 

  • Idler, D. R. and Crim, L. W. (1984). Gonadotropin releasing factor(s) (GtH-RF) from hypothalamus of winter flounder. In Lofts, B. (ed.) Proceedings of the Ninth International Symposium on Comparative Endocrinology. (Hong Kong: University of Hong Kong Press) (In press)

    Google Scholar 

  • Kent, J. S., Vickery, B. H. and McRae, G. I. (1980). The use of a cholesterol matrix pellet implant for early studies on the prolonged release in animals of agonist analogues of luteinizing hormone releasing hormone. Presented at 7th International Symposium (Controlled Release of Bioactive Materials), Fort Lauderdale, Florida

    Google Scholar 

  • King, J. A. and Millar, R. P. (1979). Heterogeneity of vertebrate luteinizing releasing hormone. Science, 206, 67

    Article  PubMed  CAS  Google Scholar 

  • King, J. A. and Millar, R. P. (1980). Comparative aspects of luteinizing hormone-releasing hormone structure and function. Endocrinology, 106, 707

    Article  PubMed  CAS  Google Scholar 

  • King, J. A. and Millar, R. P. (1982). Structure of chicken hypothalamic luteinizing hormone-releasing hormone. II. Isolation and characterization. J. Biol. Chem., 257, 10729

    PubMed  CAS  Google Scholar 

  • Lam, T. J. (1982). Application of endocrinology to fish culture. Can. J. Fish. Aquat. Sci., 39, 111

    Article  CAS  Google Scholar 

  • Lam, T. J., Pandey, S. and Hoar, W. S. (1975). Induction of ovulation in goldfish by synthetic luteinizing hormone-releasing hormone (LH-RH). Can. J. Zool., 53, 1189

    Article  PubMed  CAS  Google Scholar 

  • Licht, P. (1974). Induction of sperm release in frogs by mammalian gonadotropin-releasing hormone. Gen. Comp. Endocrinol., 23, 352

    Article  PubMed  CAS  Google Scholar 

  • Licht, P. (1980). Evolutionary and functional aspects of pituitary gonadotropins in the green turtle, Chelonia mydas. Am. Zool., 20, 565

    CAS  Google Scholar 

  • Licht, P., Owens, D. W., Cliffton, K. and Penaflores, C. (1982). Changes in LH and progesterone associated with the nesting cycle and ovulation in the olive ridley sea turtle, Lepidochelys olivacea Gen. Comp. Endocrinol., 48, 247

    Article  PubMed  CAS  Google Scholar 

  • Lin, H.-R., Peter, R. E., Nahorniak, C. S. and Bres, O. (1984). Actions of the superactive analogue Des-Gly10[d-Ala6]LRH ethylamide (LRH-A) on gonadotropin secretion in goldfish. In Lofts, B. (ed.) Proceedings of the Ninth International Symposium on Comparative Endocrinology. (Hong Kong: University of Hong Kong Press) (In press).

    Google Scholar 

  • McCreery, B. R., Licht, P., Barnes, R., Rivier, J. E. and Vale, W. W. (1982). Actions of agonistic and antagonistic analogs of gonadotropin releasing hormone (Gn-RH) in the bullfrog Rana catesbeiana. Gen. Comp. Endocrinol., 46, 511

    Article  PubMed  CAS  Google Scholar 

  • Mazzi, V., Vellano, C., Colucci, D. and Merlo, A. (1974). Gonadotropin stimulation by chronic administration of synthetic luteinizing hormone-releasing hormone in hypophysectomized pituitary grafted male newts. Gen. Comp. Endocrinol., 24, 1

    Article  PubMed  CAS  Google Scholar 

  • Nozaki, M. and Kobayashi, H. (1979). Distribution of LHRH-like substance in the vertebrate brain as revealed by immunohistochemistry. Arch. Histol. Jpn., 42, 201

    PubMed  CAS  Google Scholar 

  • Peter, R. E. (1982). Nature, localization and actions of neurohormones regulating gonadotropin secretion in teleosts. In Richter, C. J. J. and Goos, H. J. Th. (eds.) Proceedings of the International Symposium on Reproductive Physiology of Fish, pp. 30–40. Pudoc: Wageningen

    Google Scholar 

  • Peter, R. E. and Paulencu, C. R. (1980). Involvement of the preoptic region in gonadotropin release-inhibition in goldfish, Carassius auratus. Neuroendocrinology, 31, 133

    Article  PubMed  CAS  Google Scholar 

  • Sherwood, N., Eiden, L., Brownstein, M., Spiess, J., Rivier, J. and Vale, W. (1983). Characterization of a teleost gonadotropin-releasing hormone. Proc. Natl. Acad. Sci. U.S.A., 80, 2794

    Article  PubMed  CAS  Google Scholar 

  • Sokolowska, M., Popek, W. and Bieniarz, K. (1978). Synthetic releasing hormones LH/FSH-RH and LH-RH: effect of intracerebral and intramuscular injections on female carp (Cyprinus carpio L.) maturation. Ann. Biol. Anim. Biochim. Biophys., 18, 963

    Article  CAS  Google Scholar 

  • Sokolowska, M., Peter, R. E., Nahorniak, C. S., Pan, C. H., Chang, J. P., Crim, L. W. and Weil, C. (1983). Induction of ovulation in goldfish, Carassius auratus, by pimozide and analogues of LH-RH. Aquaculture, 36, 71

    Article  Google Scholar 

  • Sower, S. A., Schreck, C. B. and Donaldson, E. M. (1982). Hormone-induced ovulation of coho salmon (Oncorhynchus kisutch) held in seawater and fresh water. Can. J. Fish. Aquat. Sci., 39, 627

    Article  CAS  Google Scholar 

  • Thornton, V. F. and Geschwind, I.I. (1974). Hypothalamic control of gonadotropin release in amphibia: evidence from studies of gonadotropin release in vitro and in vivo. Gen. Comp. Endocrinol., 23, 294

    Article  PubMed  CAS  Google Scholar 

  • Van Der Kraak, G., Lin, H.-R., Donaldson, E. M., Dye, H. M. and Hunter, G. A. (1982). Effects of LH-RH and des-Gly10[d-Ala6]LH-RH-ethylamide on plasma gonadotropin levels and oocyte maturation in adult female coho salmon (Oncorhynchus kisutch). Gen. Comp. Endocrinol., 49, 470

    Article  Google Scholar 

  • Vellano, C., Bona, A., Mazzi, V. and Colucci, D. (1974). The effect of synthetic luteinizing hormone releasing hormone on ovulation in the crested newt. Gen. Comp. Endocrinol., 24, 338

    Article  PubMed  CAS  Google Scholar 

  • Weil, C., Breton, B. and Reinaud, P. (1975). Etude de la réponse hypophysaire à l’administration de Gn-RH exogène au cours du cycle reproducteur annuel chez la carpe Cyprinus carpio L. C. R. Acad. Sci. 280D, 2469

    Google Scholar 

  • Weil, C., Billard, R., Breton, B. and Jalabert, B. (1978). Pituitary response to LH-RH at different stages of gametogenesis in the rainbow trout (Salmo gairdnerî). Ann. Biol. Anim. Biochim., Biophys., 18, 863

    Article  CAS  Google Scholar 

  • Weil, C., Fostier, A., Horvath, L., Marlot, S. and Berscenyl, M. (1980). Profiles of plasma gonadotropin and 17β-estradiol in the common carp, Cyprinus carpio L., as related to spawning induced by hypophysation or LH-RH treatment. Reprod. Nutr. Devel., 20, 1041

    Article  CAS  Google Scholar 

  • Weil, C. and Crim, L. W. (1983). Administration of LHRH analogues in various ways: effect on the advancement of spermiation in prespawning landlocked salmon, Salmo salar. Aquaculture 35, 103

    Article  CAS  Google Scholar 

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  1. L. W. Crim
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B. H. Vickery J. J. Nestor Jr. E. S. E. Hafez

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© 1984 MTP Press Limited

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Crim, L.W. (1984). Actions of LHRH and its analogs in lower vertebrates. In: Vickery, B.H., Nestor, J.J., Hafez, E.S.E. (eds) LHRH and Its Analogs. Advances in Reproductive Health Care, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5588-2_29

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  • DOI: https://doi.org/10.1007/978-94-009-5588-2_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8963-0

  • Online ISBN: 978-94-009-5588-2

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