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Interrelationship Among Aging, Cancer and Differentiation pp 23–34Cite as

Overview of the Pathobiology of Aging

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Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 18))

Abstract

The nature of biological senescence is reviewed with regards to definitions, phenotypes, genetic controls, potential mechanisms and certain experiments relevant to somatic mutational theories. Of special relevance to the theme of this conference is the evidence for a widespread loss of proliferative homeostasis and the evidence for chromosomal instability, both of which may contribute to the pathogenesis of neoplasia and might be related to aspects of differentiation.

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Author information

Authors and Affiliations

  1. Departments of Pathology and Genetics, University of Washington, Seattle, Washington, 98195, USA

    George M. Martin

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  1. George M. Martin
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

    Bernard Pullman

  2. Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA

    Paul O. P. Ts’o

  3. National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA

    Edmond L. Schneider

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© 1985 D. Reidel Publishing Company, Dordrecht, Holland

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Martin, G.M. (1985). Overview of the Pathobiology of Aging. In: Pullman, B., Ts’o, P.O.P., Schneider, E.L. (eds) Interrelationship Among Aging, Cancer and Differentiation. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5466-3_4

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  • DOI: https://doi.org/10.1007/978-94-009-5466-3_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8913-5

  • Online ISBN: 978-94-009-5466-3

  • eBook Packages: Springer Book Archive

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