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Diseases of Aging: Viral Genes and Perturbation of Differentiated Functions in Persistent Infection

  • Conference paper
Interrelationship Among Aging, Cancer and Differentiation

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 18))

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Abstract

Here we present evidence that viruses alter the differentiated (luxury) function of a cell without affecting the cell’s vital (house keeping) activity. The outcome may be disturbed homeostasis and, thereby, disease. These events can occur with neither altered cell morphology nor cell destruction. Hence, viruses can induce disease by “silently” infecting cells in the absence of ordinarily expected footprints of viral infection. These events may foment the fatal physiologic breakdowns characteristic of aging.

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Author information

Authors and Affiliations

  1. Scripps Clinic and Research Foundation, La Jolla, CA, USA

    Michael B. A. Oldstone

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  1. Michael B. A. Oldstone
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Editor information

Editors and Affiliations

  1. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Paris, France

    Bernard Pullman

  2. Division of Biophysics, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, Maryland, USA

    Paul O. P. Ts’o

  3. National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA

    Edmond L. Schneider

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© 1985 D. Reidel Publishing Company, Dordrecht, Holland

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Oldstone, M.B.A. (1985). Diseases of Aging: Viral Genes and Perturbation of Differentiated Functions in Persistent Infection. In: Pullman, B., Ts’o, P.O.P., Schneider, E.L. (eds) Interrelationship Among Aging, Cancer and Differentiation. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5466-3_28

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  • DOI: https://doi.org/10.1007/978-94-009-5466-3_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8913-5

  • Online ISBN: 978-94-009-5466-3

  • eBook Packages: Springer Book Archive

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