Skip to main content
SpringerLink
Log in

Pathogenesis of gastric mucosal damage: Contribution of the ‘mucus-bicarbonate barrier’

  • Chapter
Peptic Ulcer Disease: Basic and Clinical Aspects

Part of the book series: Developments in Gastroenterology ((DIGA,volume 7))

  • 84 Accesses

Abstract

The unique ability of the gastroduodenal mucosa to resist the corrosive effects of gastric acid and pepsin has been the subject of considerable interest and speculation over the last century. Hypotheses have emerged and floundered with regular monotony and the precise mechanisms responsible for preserving epithelial integrity still remain a mystery.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Davenport HW. Salicylate damage to the gastric mucosal barrier. N Engl J Med 1967; 267: 1307–12.

    Article  Google Scholar 

  2. Rees WDW, Turnberg LA. Mechanisms of gastric mucosal protection: a role for the mucus-bicarbonate barrier. Clin Sci 1982; 62: 343–348.

    PubMed  CAS  Google Scholar 

  3. Bickel M, Kaufman G. Gastric gel mucus thickness: Effect of distension, 16,16dimethyl prostaglandin E and carbenoxolone. Gastroenterology 1981; 80: 770–775.

    PubMed  CAS  Google Scholar 

  4. Kerss S, Allen A, Garner G. A simple method for measuring thickness of the mucus gel layer adherent to rat, frog and human gastric mucosa: Influence of feeding, prostaglandin, N-acetyl cysteine and other agents. Clin Sci 1982; 63: 187–195.

    PubMed  CAS  Google Scholar 

  5. Allen A. Structure of gastrointestinal mucus glycoproteins and the viscous and gel forming properties of mucus. Brit Med Bull 1978; 34: 28–33.

    PubMed  CAS  Google Scholar 

  6. Allen A, Pain RH, Robson TR. Model for the structure of the gastric mucus gel. Nature 1976; 264: 88–89.

    Article  PubMed  CAS  Google Scholar 

  7. Pearson J, Allen A, Venables C. Gastric mucus: Isolation and polymeric structure of the undegraded glycoprotein: its breakdown by pepsin. Gastro- entrology 1980; 78: 709–715.

    CAS  Google Scholar 

  8. Williams SE, Turnberg LA. Retardation of acid diffusion by pig gastric mucus: A potential role in mucosal protection. Gastroenterology 1980; 79: 299–304.

    PubMed  CAS  Google Scholar 

  9. Flemstrom G. Gastric secretion of bicarbonate. In: Johnson RL, Christensen H, Grossman MI, Jacobson ED, Schultz SG (Eds). Physiology of the Gastro intestinal Tract. New York, Raven Press 1981;vol 1: 603–614.

    Google Scholar 

  10. Flemstrom G, Garner A. Gastroduodenal HCO~3 transport: Characteristics and proposed role in acidity regulation and mucosal protection. Am J Physiol 1982; 242 (Gastrointest Liver Physiol 5): G183–G193.

    PubMed  CAS  Google Scholar 

  11. Rees WDW, Garner A, Turnberg LA, Gibbons LC. Studies of acid and alkali secretion by rabbit gastric fundus in vitro: Effect of low concentrations of sodium taurocholate. Gastroenterology 1982; 83: 435–440.

    PubMed  CAS  Google Scholar 

  12. Rees WDW, Gibbons LC, Turnberg LA. Effects of non-steroidal antiinflammatory drugs and prostaglandins on alkali secretion by rabbit gastric fundus in vitro. Gut 1983; 24: 784–789.

    Article  PubMed  CAS  Google Scholar 

  13. Rees WDW, Botham D, Turnberg LA. A demonstration of bicarbonate production by the normal human stomach in vivo. Dig Dis Sci 1982; 27: 961–966.

    Article  PubMed  CAS  Google Scholar 

  14. Flemstrom G, Heylings JR, Garner A. Gastric and duodenal HCO3 transport in vitro: Effects of hormones and local transmitters. Am J Physiol 1982; 242 (Gastrointest Liver Physiol 5): G100–G110.

    PubMed  CAS  Google Scholar 

  15. Garner A, Hurst BC. Alkaline secretion by the canine Heidenhain pouch in response to endogenous acid, some gastrointestinal hormones and prosta- glandins. In: Gati T, Szollar LG, Ungvary CTY (Eds). Advances in Physiological Science, Vol 12. Nutrion, Digestion and Metabolism, 1981.

    Google Scholar 

  16. Heylings JR, Garner A, Flemstrom G. Regulation of gastroduodenal HCO” transport by luminal acid in the frog in vitro. Am J Physiol 1984; 246 (Gastro- intest Liver Physiol 9): G235–G242.

    PubMed  CAS  Google Scholar 

  17. Rees WDW, Gibbons LC, Warhurst G, Turnberg LA. Studies of bicarbonate secretion in the normal human stomach in vivo: Effect of aspirin, sodium tauro- cholate and prostaglandin E. In: Allen A, Flemstrom G, Garner A, Silen W, Turnberg LA (Eds). Mecnanisms of Mucosal Protection in the Upper Gastrointestinal Tract. New York, Raven Press, 1984.

    Google Scholar 

  18. Heatley NG. Mucosubstance as a barrier to diffusion. Gastroenterology 1959; 37: 313–317.

    PubMed  CAS  Google Scholar 

  19. Williams SE, Turnberg LA. Studies of the ‘protective’ properties of gastric mucus: Evidence for a ‘mucus-bicarbonate’ barrier. Gut 1981; 22: 94–96.

    Article  PubMed  CAS  Google Scholar 

  20. Ross IN, Bahari HMM, Turnberg LA. The pH gradient across mucus adherent to rat fundic mucus in vivo and effects of possible damaging agents. Gastroenterology 1981; 81: 713–718.

    PubMed  CAS  Google Scholar 

  21. Flemstrom G, Kivilaakso E. Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkali secretion. Gastroenterology 1983; 84: 787–794.

    PubMed  CAS  Google Scholar 

  22. Younan F, Pearson J, Allen A, Venables C. Changes in the structure of the mucus gel on the mucosal surface of the stomach in association with peptic ulcer disease. Gastroenterology 1982; 82: 827–831.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hope Hospital, University of Manchester, Salford, UK

    W. D. W. Rees M.D., M.R.C.P. & Linda Gibsons (Technical assitant)

Authors
  1. W. D. W. Rees M.D., M.R.C.P.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Linda Gibsons
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine, Sophia Ziekenhuis, Zwolle, 8000 GK, The Netherlands

    G. F. Nelis MD (Consultant Physician) (Consultant Physician)

  2. Department of Surgery, Sophia Ziekenhuis, Zwolle, 8000 GK, The Netherlands

    J. Boevé M.D. (Consultant Surgeon) (Consultant Surgeon)

  3. Department of Gastroenterology & Nutrition, Central Middlesex Hospital, London, NW10 7NS, UK

    J. J. Misiewics B.Sc, M.B., F.R.C.P. (Consultant Physician and Head of the Department) (Consultant Physician and Head of the Department)

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Rees, W.D.W., Gibsons, L. (1985). Pathogenesis of gastric mucosal damage: Contribution of the ‘mucus-bicarbonate barrier’. In: Nelis, G.F., Boevé, J., Misiewics, J.J. (eds) Peptic Ulcer Disease: Basic and Clinical Aspects. Developments in Gastroenterology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5034-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-5034-4_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8730-8

  • Online ISBN: 978-94-009-5034-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation