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Medical treatment of peptic ulcer with prostaglandins

  • Chapter
Peptic Ulcer Disease: Basic and Clinical Aspects

Part of the book series: Developments in Gastroenterology ((DIGA,volume 7))

Abstract

Several prostaglandins have been shown to inhibit the secretion of acid and pepsin by the stomach of various species. They possess anti-ulcer acitivity in the upper gastrointestinal tract in animal models and have beneficial ‘cytoprotective’ effects on the intergrity of the gastric mucosa when it is exposed to noxious stimuli in animals and man. The ‘cytoprotective’ effect of prostaglandins is independent of the anti-secretory action.1

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References

  1. Robert A. Cytoprotection by prostaglandins. Gastroenterology 1979; 77: 761–7.

    Google Scholar 

  2. Tijtgat GN, Henzen-Logmans SC, van Minnen AJ. Human gastric mucosal changes after oral 15(R)-15 methyl prostaglandinE2 (Pg) administration. Gastroenterology 1982; 82: 1200A.

    Google Scholar 

  3. Johansson C, Aly A, Kollberg B, Rubio C, Erikoinen T, Helander HF. In: Samuelson B, Paoletti R, Ram well P (Eds). Advances in Prostaglandins, Thromboxane, and Leukotriene Research, Vol 12. New York, Raven Press 1982 403–407.

    Google Scholar 

  4. Reinhart WH, Miiller O, Halter F. Influence of long-term 16,16-dimethyl prostaglandin E2 treatment on the rat gastrointestinal mucosa. Gastroenterology 1983; 85: 1003–1010.

    PubMed  CAS  Google Scholar 

  5. Hart Hansen O, Pedersen T, Larsen JK. Gastric mucosal cell proliferation in duodenal ulcer patients. Gut 1975; 16: 23–7.

    Google Scholar 

  6. Willems G, Vansteenkiste Y, Verbenstel S. Autoradiographic study of cell renewal in fundic mucosa of fasting dogs. Acta Anat 1971; 80: 23–32.

    Article  PubMed  CAS  Google Scholar 

  7. Offerhaus GJA, Tijtgat GN, Samson G, Weinstein WM. Cell proliferation kinetics of the gastric mucosa after oral 15(R)-15-methyl prostaglandin E2 (PG) administration. Gastroenterology 1984; 86: 1199A.

    Google Scholar 

  8. Tijtgat GNJ, Offerhaus GJA, van Minnen AJ, Everts V, Hensen-Logmans SC, Samson G. Influence of oral 15(R)-15-methyl PGE2 on human gastric mucosa. A light — microscopic, cell-kinetic and ultrastructural study. Gastroenterology: to be published.

    Google Scholar 

  9. Robert A, Hanchar AJ, Lancaster C, Nezamis JE, Culp JW, Li LH. Prevention of cellular shedding as a mechanism of gastric cytoprotection by prostaglandins. Gastroenterology 1980; 78: 1244.

    Google Scholar 

  10. Ruppin H, Person B, Robert A, Domschke W. Gastric cytoprotection in man by prostaglandin Er Scand J Gastroenterol 1981; 16: 647–652.

    Article  PubMed  CAS  Google Scholar 

  11. Halter F, Meyrat P, Fritsche R, Miiller O, Lentze MJ, Koelz HR. Both topical and systemic treatment with 16, 16-dimethyl prostaglandin E2 are trophic to rat gastric mucosa. Scand J Gastroenterology 1984a; 19 (Suppl 101): 47–54.

    CAS  Google Scholar 

  12. Halter F, Reinhart WH, Koelz HR, Meyrat P, Lentze MJ, Miiller O. 16,16-dimethyl prostaglandin E2 stimulates growth and maturation of rat gastric and small intestinal mucosa. Scand J Gastroenteroly 1984b; 19(Suppl 92): 178 —183.

    CAS  Google Scholar 

  13. Ramwell PW. Biologic importance of arachidonic acid. Arch Intern Med 1981; 14: 275.

    Article  Google Scholar 

  14. Ahlquist DA, Duenes JA, Madson TH et al. Prostaglandin generation from gastroduodenal mucosa: Regional and species differences. Prostaglandins 1982; 24: 115.

    Article  PubMed  CAS  Google Scholar 

  15. Johansson C, Kollberg B. Stimulation by itnragastrically administered E2 prostaglandins of human gastric mucus output. Eur J Clin Invest 1979; 9: 229.

    Article  PubMed  CAS  Google Scholar 

  16. Robert A, Nezamis JE, Lancaster C et al. Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HC1, NaOH, hypertonic NaCl and thermal injury. Gastroenterology 1979; 77: 433.

    PubMed  CAS  Google Scholar 

  17. Allen A, Garner A. Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. Gut 1980; 21: 249.

    Article  PubMed  CAS  Google Scholar 

  18. Konturek SJ, Brzozowski T, Piastucki I et al. Role of locally generated prostaglandins in adaptive gastric cytoprotection. Dig Dis Sci 1982; 27: 967.

    Article  PubMed  CAS  Google Scholar 

  19. Sharon P, Zifroni A, Ligumsky M. Prostanoid synthesis by cultered gastric and duodenal mucosa: Possible role in the pathogenesis of duodenal ulcer. Scand J Gastroenterology 1983; 18: 1045–9.

    Article  Google Scholar 

  20. Ahlquist DA, Dozius RR, Zinsmeister AR et al. Duodenal prostaglandin synthesis and acid load in health and in duodenal ulcer disease. Gastroenterology 1983; 85: 522.

    PubMed  CAS  Google Scholar 

  21. Wright JP, Young GO, Klaff LJ et al. Gastric mucosal prostaglandin E levels in patients with gastric ulcer disease and carcinoma. Gastroenterology 1982; 82: 263.

    CAS  Google Scholar 

  22. Reele GB, Bohan D. Oral antisecretory activity of prostaglandin E2 in man. Dig Dis Sci 1984; 29: 390–393.

    Google Scholar 

  23. Samuelsson B, Grantstrom E, Green K, Hamberg M. Metabolism of prostaglandins. Ann NY Acad Sci 1971; 180: 139–161.

    Google Scholar 

  24. Magerlein BJ, Ducharme DW, Magee WE, Miller WL, Robert A, Weeks JR. Synthesis and biological properties of 16-alkylprostaglandins. Prostaglandins 1973; 4(1): 143–144.

    Google Scholar 

  25. Karim SMM, Carter DC, Bhana D, Ganesan PA. Effect of orally administered prostaglandin E2 and its 15-methyl analogues on gastric secretion. Brit Med J 1973; 1: 143–146.

    Google Scholar 

  26. Salmon JA, Karim SMM, Carter DC, Adaikan PG, Bhana D. Effect of 15(R) 15-methyl PGE2 methylester on basal and pentagastrin stimulated pepsin secretion in men. Int Res Comm Syst (Medical Science) 1975; 3: 83.

    CAS  Google Scholar 

  27. Konturek SJ, Kwiecien N, SwierczekJ, Oleksy J, Sito E, Robert A. Comparison of methylated prostaglandin E2 analogues given orally in the inhibition of gastric responses to pentagastrin and peptone meal in man. Gastroenterology 1976; 70: 683–687.

    Google Scholar 

  28. Robert A, Schultz JR, Nezamis JE, Lancaster C. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2 and 16,16 dimethyl PGE2. Gastroenterology 1976; 70: 359–370.

    PubMed  CAS  Google Scholar 

  29. Fung WP, Lee SK, Karim SMM. Effect of prostaglandin 15(R) 15-methyl- E2-methyl ester on the gastric mucosa in patients with peptic ulceration. An endoscopic and histological study. Prostaglandin 1974; 5: 465–472.

    Article  CAS  Google Scholar 

  30. Kollberg B, Slezak P. The effect of prostaglandin E2 on duodenal ulcer healing. Prostaglandins 1982: 24: 527.

    Article  PubMed  CAS  Google Scholar 

  31. Dajani EZ, Driskill D, Bianchi R, Collins P, Pappo R. Sc 29333: A potent inhibitor of canine gastric secretion. Am J Dig 1976; 21: 1049–1057.

    Google Scholar 

  32. Colton DG, Driskill DR, Phillips EL, Poy P, Dajani EZ. Effect of SC 29333 an inhibitor of gastric secretion, on canine gastric mucosal blood flow and serum gastrin levels. Arch Int Pharmacodyn Ther 1978; 236: 86–95.

    Google Scholar 

  33. Ramage JK, Denton A, Williams JG. Duration of action of Misoprostol, an orally active synthetic analogue of prostaglandin. Gut 1983; 24: A973.

    Google Scholar 

  34. Larsen KR, Jensen NF, Davis EK, Jensen JC, Moody FG. The cytoprotective effects of (+)-15-deoxy-16-methyl PGE1 methyl ester (SC 29333) versus aspirin on shock gastric ulcerogenesis in the dog. Prostaglandin 1981; 21 (Suppl): 119–124.

    Google Scholar 

  35. Cohen MM, Clark L, Armstrong L, D’Sousa J. Reduced aspirin fecal blood loss with simultaneous administration of misoprostol (PGE1? methyl analogue). Gastroenterology 1983; 84: 1126.

    Google Scholar 

  36. Gullikson G, Anglin C, Kessler L, Smeach S, Crowder S, Bauer R, Dajani EZ. Misoprostol prevents aspirin-induced damage in canine Heidenhain pouches. Gastroenterology 1983; 84: 1176.

    Google Scholar 

  37. Hunt JN, Smith JL, Jiang CL, Kessler L. Effect of synthesic prostaglandin Ej-analogue on aspirin-induced gastric bleeding and secretion. Dig Dis Sci 1983; 28: 897–902.

    Google Scholar 

  38. Bianchi RG, Casler JJ, Dajani EZ. Gastric antisecretory and antiulcer activity of SC 29333: A synthetic E-prostaglandin analogue. Pharmacologist 1981; 23: 121.

    Google Scholar 

  39. Tijtgat GN. Therapeutic use of prostaglandins in gastrointestinal disease. In: van Maercke YMF, van Moer EMJ, Pelckmans PAR (Eds). Stomach Diseases. Current status. Excerpta Medica, Amsterdam - Oxford - Princeton 1981: 49–54.

    Google Scholar 

  40. Fung WP, Karim SMM, Tye CY. Effect of 15(R) 15-methyl-prostaglandin E2 methyl ester on healing of gastric ulcers. Lancet 1974; 2: 10–12.

    Article  PubMed  CAS  Google Scholar 

  41. Fung WP, Karim SMM. Effect of prostaglandin E2 on the healing of gastric ulcers: A double-blind endoscopic trial. Aust N Z J Med 1976; 6: 121–122.

    Article  PubMed  CAS  Google Scholar 

  42. Gibinski K, Rybicka J, Mikos E, Nowak A. Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues. Gut 1977; 18: 636–639.

    Google Scholar 

  43. Rybicka J, Gibinsky K. Methyl-prostaglandin analogues for healing of gastroduodenal ulcers. Scand J Gastroenterology 1978; 13: 155–159.

    Article  CAS  Google Scholar 

  44. Chen F et al. Effect of prostaglandin E2 and 15(R)-15-methyl PGE2 on duodenal ulcer. Singapore Med J 1980; 21: 596.

    PubMed  CAS  Google Scholar 

  45. Tijtgat GNJ, Huibregtse K. A double-blind trial with 15(R)-15-methyl PGE2 in duodenal ulcer. Data on file Upjohn Company Kalamozoo, USA 1982.

    Google Scholar 

  46. Vantrappen G, Jansen J, Popiela J, Kulig J, Tijtgat GN, Huibregtse K, Lambert R, Pauchard JP, Robert A. Effect of 15(R)-15-methyl prostaglandin E2 (Arbaprostil) on the healing of duodenal ulcers. A double-blind multicentre study. Gastroenterology 1982; 83: 357–363.

    PubMed  CAS  Google Scholar 

  47. Brand D et al. Misoprostol, a prostaglandin Ej analogue, is effective in healing duodenal ulcers: Results of a multi-center controlled trial. Gastroenterology 1984; 86: 1034.

    Google Scholar 

  48. Arvanitakis C et al. A comparative clinical trial of cimetidine and misoprostol (methyl PGEJ in the treatment of duodenal ulcer. Gastroenterology 1984; 86: 1017.

    Google Scholar 

  49. Simon B et al. Misoprostol and cimetidine in a short-term treatment of duodenal ulcer. A double-blind, randomized multi-center study in Germany. Gastroenterology 1984; 86: 1253.

    Google Scholar 

  50. Nicholson PA. On behalf of an International Study Group. A multi-center international contolled comparison of two dosage regimes of misoprostol and cimetidine in the treatment of duodenal ulcer in out patients. To be published.

    Google Scholar 

  51. Shield MJ. Interim results of a multi-center international comparison of misoprostol and cimetidine in the treatment of outpatients with benign gastric ulcers. To be published.

    Google Scholar 

  52. Bardhan K et al. Trimoprostil vs. cimetidine in duodenal ulcer. Gut 1983; 24: A580.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Gastroenterology-Hepatology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands

    G. N. J. Tijtgat M.D.

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  1. G. N. J. Tijtgat M.D.
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Editors and Affiliations

  1. Department of Internal Medicine, Sophia Ziekenhuis, Zwolle, 8000 GK, The Netherlands

    G. F. Nelis MD (Consultant Physician) (Consultant Physician)

  2. Department of Surgery, Sophia Ziekenhuis, Zwolle, 8000 GK, The Netherlands

    J. Boevé M.D. (Consultant Surgeon) (Consultant Surgeon)

  3. Department of Gastroenterology & Nutrition, Central Middlesex Hospital, London, NW10 7NS, UK

    J. J. Misiewics B.Sc, M.B., F.R.C.P. (Consultant Physician and Head of the Department) (Consultant Physician and Head of the Department)

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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Tijtgat, G.N.J. (1985). Medical treatment of peptic ulcer with prostaglandins. In: Nelis, G.F., Boevé, J., Misiewics, J.J. (eds) Peptic Ulcer Disease: Basic and Clinical Aspects. Developments in Gastroenterology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5034-4_11

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  • DOI: https://doi.org/10.1007/978-94-009-5034-4_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8730-8

  • Online ISBN: 978-94-009-5034-4

  • eBook Packages: Springer Book Archive

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