Skip to main content
SpringerLink
Log in
Book cover

Radioisotope studies in cardiology pp 295–317Cite as

Imaging with 123I Labelled Fatty Acids

  • Chapter

  • 37 Accesses

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 8))

Abstract

Thallium-201 scintigraphy and radionuclide ventriculography with Tc99m-labelled albumin are now routinely used in the diagnosis of a variety of cardiac disorders, to provide information which is mainly directed to morphologic and functional aspects of disease. However, interest in cardiac metabolism has increased as a result of growing concern of the fundamental aspects of heart disease. In the metabolic chain for the production of adenosine triphosphate by the myocardial cell the preferential use of fatty acids as substrate is well established (1–4, 9). An additional diagnostic approach is the use of 123I labelled fatty acids

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bing RJ, Cardiac Metabolism. Physiol. Rev. 45:171, 1965.

    PubMed  CAS  Google Scholar 

  2. Opie LH, Metabolism of the heart in health and disease. Part I. Amer. Heart J. 76: 685, 1968

    Article  PubMed  CAS  Google Scholar 

  3. Neely JR, Rovetto MJ, Oram JF, Myocardial utilization of carbohydrate and lipids. Progr. cardiovasc. Dis. 15: 289, 1972

    CAS  Google Scholar 

  4. Neely JR, Morgan HE, Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Ann. Rev. Physiol. 34: 413, 1974

    Article  Google Scholar 

  5. Evans JR, Gunton RW, Baker RG et al: Use of radioiodinated fatty acid for photoscans of the heart. Circulat. Res. 16: 1, 1965

    PubMed  CAS  Google Scholar 

  6. Robinson GD, Lee AW, Radioiodinated fatty acids for heart imaging: Iodine monochloride addition compared with iodide replacement labelling. J. nucl. Med. 16: 17, 1975

    PubMed  CAS  Google Scholar 

  7. Poe ND, Robinson GD, Graham LS et al, Experimental basis for myocardial imaging with 123I-labeled hexadecanoic acid. J. nucl. Med.. 17: 1077, 1976

    PubMed  CAS  Google Scholar 

  8. Machulla HJ, Stöcklin G, Kupfernagel CH et al, Comparative evaluation of fatty acids labelled with C-11, CI-34m, Br-77 and I-123 for metabolic studies of the myocardium: Concise communication. J. nucl. Med. 19: 298, 1978

    PubMed  CAS  Google Scholar 

  9. Machulla HJ, Marsmann M, Dutschka K, Biochemical concept and synthesis of a radioiodinated phenylfatty acid for in vivo metabolic studies of the myocardium. Eur. J. Nucl. Med. 5:171, 1980.

    Article  PubMed  CAS  Google Scholar 

  10. Freundlieb Ch, Höck A, Vyska K et al, Myocardial imaging and metabolic studies with (17–1231) iodoheptadecanoic acid. J. nucl. Med. 21: 1043, 1980

    PubMed  CAS  Google Scholar 

  11. Vyska K, Höck A, Freundlieb C et al, Stoffwechseluntersuchung am Herzen mit 123J-Fettsäuren und 11C-Methylglukose. Nuklearmedizin 20: 148, 1981.

    PubMed  CAS  Google Scholar 

  12. Höck A, Freundlieb Ch, Vyska K et al, Myocardial imaging and metabolic studies with (17–123I) iodoheptadecanoic acids in patients with idiopathic congestive cardiomyopathy. J. nucl. Med. 24: 22, 1983

    PubMed  Google Scholar 

  13. Feinendegen LE, Vyska K, Freundlieb Ch et al, Non invasive analysis of metabolic reactions in body tissues, the case of myocardial fatty acids. Eur. J. Nucl. Med. 6: 191, 1981

    Article  PubMed  CAS  Google Scholar 

  14. Van der Wall EE, Den Hollander W, Heidendal GAK et al, Dynamic myocardial scintigraphy with 123l-labeled free fatty acids in patients with myocardial infarction. Eur. J. Nucl. Med. 6: 383, 1981

    PubMed  Google Scholar 

  15. Van der Wall EE, Heidendal GAK, Den Hollander W et al, Metabolic myocardial imaging with 123I-labeled heptadecanoic acid in patients with angina pectoris. Eur. J. Nucl. Med. 6: 391, 1981

    PubMed  Google Scholar 

  16. Knapp FF, Ambrose KR, Callahan AP et al, Effects of chain length and Tellurium position on the myocardial uptake of Te-123m fatty acids. J. nucl. Med. 22: 988, 1981

    PubMed  CAS  Google Scholar 

  17. Elmaleh DR, Knapp FF, Yasuda T et al, Myocardial imaging with 9-(Te-123m) Telluroheptadecanoic acid. J. nucl. Med. 22: 994, 1981

    PubMed  CAS  Google Scholar 

  18. Goodman MM, Knapp FF, Callahan AP, et al, A new, well retained myocardial imaging agent: Radioiodinated 15-(p-Iodo- phenyl)-6-Tellurapentadecanoic acid. J. nucl. Med. 23: 904, 1982

    PubMed  CAS  Google Scholar 

  19. Dudczak R . Höfer R, Myocardial scintigraphy with I-123 labeled fatty acids. Summary of a Round Tabel Discussion. J. Radioanal. Chem. 79:329, 1983.

    Article  Google Scholar 

  20. Angelberger P, Wagner-Löffler M, Dudczak R et al, I-123(131) labeled aliphatic and aromatic fätty acids: optimized preparation and biodistribution. In: Radioaktive Isotope in Klinik und Forschung, Vol. 15. Höfer R, Bergmann H (eds), H. Egermann, Vienna, pp 249, 1982

    Google Scholar 

  21. Schmoliner R, Dudczak R, Kronik G et al, Thallium-201-Myokardszintigraphie nach hochdosierter Dipyridamolgabe, Z. Kardiol. 70: 111, 1981

    CAS  Google Scholar 

  22. Vogel RA, Quantitative aspects of myocardial perfusion imaging. Seminars Nucl. Med. 10: 146, 1980

    CAS  Google Scholar 

  23. Botvinick EH, Dunn RF, Hattner RS et al, A consideration of factors affecting the diagnostic accuracy of thallium 201 myocardial perfusion scintigraphy in detecting coronary artery disease. Seminars Nucl. Med. 10: 157, 1980

    CAS  Google Scholar 

  24. Pohost GM, Alpert NM, Ingwall JS et al, Thallium redistribution: Mechanisms and clinical utility. Seminars Nucl. Med. 10: 70, 1980

    CAS  Google Scholar 

  25. Dudczak R, Schmoliner R, Angelberger P et al: Myocardial perfusion and metabolism as assessed by Tl-201 and I-123 heptadecanoic acid (HDA) scintigraphy. Nuklearmedizin suppl. 19: 540, 1982

    Google Scholar 

  26. Opie IH, Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction. Amer. J. Cardiol. 36: 938, 1975

    Article  PubMed  CAS  Google Scholar 

  27. Dudczak R, Schmoliner R, Derfler K et al, Effect of ischemia and pharmacological interventions on the myocardial elimination of I-123 heptadecanoic acid. J. nucl. Med. 23: P34, 1982

    Google Scholar 

  28. Dudczak R, Schmoliner R, Angelberger P et al, Myocardial studies with I-123-p-phenyl-pentadecanoic acid in patients with coronary artery disease (CAD) and cardiomyopathy (CMP). J. nucl. Med. 23: P34, 1982

    Google Scholar 

  29. Dudczak R, Kletter K, Frischauf H et al, Myocardial turnover rates of I-123 heptadecanoic acid (HDA) and I-123 p-phenyl- pentadecanoic acid(p-IPPA). In: Radioaktive Isotope in Klinik und Forschung, Vol. 15. Höfer R, Bergmann H (eds), H. Egermann, Vienna, pp 685, 1982

    Google Scholar 

  30. Reske SN, Sauer W, Machulla HJ et al, 15(p(123I) iodophenyl) pentadecanoic acid as tracer of lipid metabolism: Comparison with (1–14c) palmitic acid in murine tissues. J. nucl. Med. 25: 1335, 1984

    PubMed  CAS  Google Scholar 

  31. Reske SN, Machulla HJ, Winkler C, Metabolism of 15-p (I-123- phenyl)-pentadecanoic acid in hearts of rats. J. nucl. Med. 23: P10, 1982

    Google Scholar 

  32. Coenen HH, Harmand MF, Kloster G et al, 15-(p-75-Br bromo- phenyl) pentadecanoic acid: Pharmacokinetics and potential as heart agent. J. nucl. Med. 22: 891, 1981

    PubMed  CAS  Google Scholar 

  33. Weiss ES, Hoffman EJ, Phelps ME et al, External detection and visualization of myocardial ischemia with 11-C-substrates in vitro and in vivo. Circulat. Res. 39: 24, 1976

    PubMed  CAS  Google Scholar 

  34. Oram JF, Bennetch SL, Neely JR, Regulation of fatty acid utilization in isolated perfused rat hearts. J. Biol. Chem. 248: 5299, 1973

    PubMed  CAS  Google Scholar 

  35. Gordon RS, Cherkes A, Gates H, Unesterified fatty acid in human blood plasma. II. The transport function of unesterifie fatty acid. J. clin. Invest. 36: 810, 1957

    Article  PubMed  CAS  Google Scholar 

  36. Fisher RB, Williamson JR, The effects of insulin, adrenaline and nutrients on the oxygen uptake of the perfused rat heart. J. Physiol. 158: 102, 1961

    PubMed  CAS  Google Scholar 

  37. Schelbert HR, Henze E, Phelps ME, Emission tomography of the heart. Seminars Nucl. Med. 10: 355, 1980

    CAS  Google Scholar 

  38. Schön HR, Schelbert HR, Robinson G et al, C-11 labeled palmitic acid for the noninvasive evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. I. Kinetics of C-11 palmitic acid in normal myocardiui Amer. Heart J. 103: 532, 1982

    Article  Google Scholar 

  39. Schön HR, Schelbert HR, Najafi A et al, C-11 labeled evaluation of regional myocardial fatty acid metabolism with positron-computed tomography. II. Kinetics of C-11 palmitic acid in acutely ischemic myocardium. Amer. Heart J. 103: 548, 1982

    Article  PubMed  Google Scholar 

  40. Lerch RA, Bergmann SR, Ambos HD et al, Effect of flow-independent reduction of metabolism on regional myocardial clearance of 11C-palmitate. Circulation 65: 731, 1982

    Article  PubMed  CAS  Google Scholar 

  41. Lerch RA, Ambos HD, Bergmann SR et al, Localization of viable, ischemic myocardium by positron-emission tomography with C-11 palmitate. Circulation 64: 689, 1981

    Article  PubMed  CAS  Google Scholar 

  42. Stein O, Stein Y, Lipid synthesis, intracellular transport and storage. Ill Electron microscopic radioautographic study of the rat heart perfused with tritiated oleic acid. J. Cell. Biology 36:63, 1968.

    Article  CAS  Google Scholar 

  43. Idell-Wenger JA, Grotyohann LW, Neely JR, Coenzyme A and carnitine distribution in normal and ischemic hearts. J. biol. Chem. 253: 4310, 1978

    PubMed  CAS  Google Scholar 

  44. Crass MF, McCaskill ES, Shipp JC et al, Metabolism of endogenous lipids in cardiac muscle: Effect of pressure development. Amer. J. Physiol. 220: 428, 1971

    PubMed  CAS  Google Scholar 

  45. Gloster J, Harris P, Fatty acid binding to cytoplasmic proteins of myocardium and red and white skeletal muscle in the rat. A possible new role for myoglobin. Biochem. biophys. Res. Commun. 74: 506, 1977

    CAS  Google Scholar 

  46. Whitmer JT, Idell-Wenger JA, Rovetto MJ et al, Control of fatty acid metabolism in ischemic and hypoxic hearts. J. biol. Chem. 253: 4305, 1978

    PubMed  CAS  Google Scholar 

  47. McMillin Wood J, Sordahl LA, Lewis RM et al, Effect of chronic myocardial ischemia on the activity of carnitine palmitylcoenzyme. A transferase of isolated canine heart mitochondria. Circul. Res. 32: 340, 1973

    Google Scholar 

  48. Dudczak R, Schmoliner R, Kletter K et al, Clinical evaluation of 123I-labeled p-phenylpentadecanoic acid (p-IPPA) for myocardial scintigraphy. J. nucl. Med. & Biol. 27: 267, 1983

    CAS  Google Scholar 

  49. Dudczak R, Myokardszintigraphie mit I-123 markierten Fettsäuren. Wien. Klin. Wschr. 95:Suppl. 143, pp 1–35, 1983.

    Google Scholar 

  50. Lerch RA, Myocardial kinetics of C-11 palmitate and 123I- heptadecanoic acid: Similarities and differences. Workshop on radiolabeled free fatty acids. Amsterdam 6. 7. 1984

    Google Scholar 

  51. Dudczak R, Kletter K, Frischauf H et al, The use of 123I- labeled heptadecanoic acid (HDA) as metabolic tracer: preliminary report. Eur. J. Nucl. Med. 9: 81, 1984

    Article  PubMed  CAS  Google Scholar 

  52. Dudczak R, Homan R, Zangeneh A et al, Myocardial metabolic studies in patients with cardiomyopathy. J. nucl. Med. 24:P20, 1983 (abstr).

    Google Scholar 

Download references

Authors
  1. R. Dudczak
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Clinical and Experimental Nuclear Medicine, University of Bonn, Federal Republic of Germany

    H. J. Biersack

  2. Department of Nuclear Medicine, Rotterdam Radio-Therapeutic Institute, Rotterdam, The Netherlands

    P. H. Cox

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Martinus Nijhoff Publishers, Dordrecht

About this chapter

Cite this chapter

Dudczak, R. (1985). Imaging with 123I Labelled Fatty Acids. In: Biersack, H.J., Cox, P.H. (eds) Radioisotope studies in cardiology. Developments in Nuclear Medicine, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5022-1_12

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-5022-1_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8724-7

  • Online ISBN: 978-94-009-5022-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation