Abstract
There is increasing evidence that interactions between mononuclear phagocytes and vascular endothelium are involved in a variety of pathological processes. In its unique anatomic location, the endothelium could serve a regulatory role in the trafficking of blood monocytes across the vascular wall. Once localized at a particular site, monocytes and macrophages may potentially exert a broad spectrum of effects on vascular wall cells through the elaboration of biologically active products (Table I). In this paper we will first briefly review studies from our laboratory and others on the role of monocyte-macrophage-derived products which affect the growth of new blood vessels (neovascularization) and the proliferation of vascular smooth muscle cells and fibroblasts. We will then present results of current work on the induction of endothelial cell procoagulant activity (PCA) by human monocyte-derived interleukin 1 (IL-1). Finally, we will report certain recent observations on direct cellular interactions between mononuclear phagocytes and vascular endothelium in vitro.
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Bevilacqua, M.P., Pober, J.S., Cotran, R.S., Gimbrone, M.A. (1985). Effects of mononuclear phagocytes and their secretory products on vascular endothelium. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5020-7_77
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DOI: https://doi.org/10.1007/978-94-009-5020-7_77
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-8723-0
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