Abstract
Antigen or mitogen activated T lymphocytes secrete lymphokines which bind to macrophages and their precursors. Such lymphokines induce growth, differentiation, and expression of a variety of effector functions of their target cells. Lymphokines are active in minute quantities and have been difficult to purify from supernatants of heterogeneous populations of lymphocytes in bulk cultures. The investigation of lymphokines made considerable progress when methods became available to maintain T lymphocytes in long-term culture. Long-term T cell lines and clones became a major source of lymphokines. These cells often secreted quantities of lymphokines sufficient for purification (1). In the future, long-term T cell lines, and hybridomas constructed with these lines, will be used to clone T lymphocyte-derived lymphokine genes.
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References
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© 1985 Martinus Nijhoff Publishers, Dordrecht
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Krammer, P.H. et al. (1985). The role of T cell clone- and hybridoma-derived lymphokines in macrophage activation. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5020-7_56
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DOI: https://doi.org/10.1007/978-94-009-5020-7_56
Publisher Name: Springer, Dordrecht
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