Abstract
The surface of the macrophage bears more than 30 distinct types of receptors (1), each of which when ligated can alter the behavior of the cell. It appears that the response of a macrophage to a given set of stimuli (or ligands) is not the simple arithmetic sum of the responses to individual stimuli. Rather, macrophages continuously process the information derived from their receptors to determine their behavior. Here we describe one instance in which information from two types of receptors is processed with the ‘AND’ function of symbolic logic: Macrophages phagocytose C3-coated erythrocytes only if both C3 receptors and fibronectin receptors are simultaneously occupied.
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© 1985 Martinus Nijhoff Publishers, Dordrecht
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Wright, S.D., Silverstein, S.C. (1985). Regulation of the function of receptors for C3b and C3bi on human mononuclear phagocytes by receptors for other ligands. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5020-7_19
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DOI: https://doi.org/10.1007/978-94-009-5020-7_19
Publisher Name: Springer, Dordrecht
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