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Inherited LFA-1, Mac-1 deficiency and its molecular biology

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Mononuclear Phagocytes
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Abstract

A family of functionally important, high molecular weight glycoproteins, i.e., the macrophage differentiation antigen (Mac-1), the lymphocyte-function assiociated antigen (LFA-1), and the p150,95 molecule, with identical β subunits but different a subunits has recently been defined on leukocyte cell surfaces in the mouse (1) and human (2). The properties of the Mac-1, LFA-1, and p150,95 family are summarized in Table 1 (1–12). The LFA-1 and Mac-1 molecules function in differing types of leukocyte adhesion reactions.

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References

  1. Sanchez-Madrid F, Simon P, Thompson S, Springer TA: Mapping of antigenic and functional epitopes on the alpha and beta subunits of two related glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med 1983, 158:586–602.

    Article  PubMed  CAS  Google Scholar 

  2. Sanchez-Madrid F, Nagy J, Robbins E, Simon P, Springer TA: A human leukocyte differentiation antigen family with distinct alpha subunits and a common beta subunit: the lymphocyte-function associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med 1983, 158:1785–1803.

    Article  PubMed  CAS  Google Scholar 

  3. Davignon D, Martz E, Reynolds T, Kürzinger K, Springer TA: Monoclonal antibody to a novel lymphocyte function-associated antigen (LFA-1): Mechanism of blocking of T lymphocyte-mediated killing and effects on other T and B lymphocyte functions. J Immunol 1981, 127:590–595.

    PubMed  CAS  Google Scholar 

  4. Kürzinger K, Reynolds T, Germain RN, Davignon D, Martz E, Springer TA: A novel lymphocyte function-associated antigen (LFA-1): cellular distribution, quantitative expression, and structure. J Immunol 1981, 127:596–602.

    PubMed  Google Scholar 

  5. Pierres M, Goridis C, Golstein P: Inhibition of murine T cell-mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94000 and 180000 molecular weight. Eur J Immunol 1982, 12:60–69.

    Article  PubMed  CAS  Google Scholar 

  6. Krensky AM, Sanchez-Madrid F, Robbins E, Nagy J, Springer TA, Burakoff SJ: The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. J Immunol 1983, 131:611–616.

    PubMed  CAS  Google Scholar 

  7. Springer T, Galfre G, Secher DS, Milstein C: Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol 1979, 9:301–306.

    Article  PubMed  CAS  Google Scholar 

  8. Ho MK, Springer TA: Mac-1 antigen: Quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen. J Immunol 1982, 128:2281–2286.

    PubMed  CAS  Google Scholar 

  9. Ault KA, Springer TA: Cross reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells. J Immunol 1981, 126:359–364.

    PubMed  CAS  Google Scholar 

  10. Beller DI, Springer TA, Schreiber RD: Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor. J Exp Med 1982, 156:1000–1009.

    Article  PubMed  CAS  Google Scholar 

  11. Arnaout MA, Todd III RF, Dana N, Melamed J, Schloss-man SF, Colten HR: Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest 1983, 72:171–179.

    Article  PubMed  CAS  Google Scholar 

  12. Wright SD, Rao PE, Van Voorhis WC, Craigmyle LS, Iida K, Talle MA, Westberg EF, Goldstein G, Silverstein SC: Identification of the C3bi receptor of human monocytes and macrophages with monoclonal antibodies. Proc Nat Acad Sci USA 1983, 80:5699–5703.

    Article  PubMed  CAS  Google Scholar 

  13. Bongrand P, Pierres M, Golstein P: T-cell mediated cytolysis: on the strength of effector-target cell interaction. Eur J Immunol 1983, 13:424–429.

    Article  PubMed  CAS  Google Scholar 

  14. Krensky AM, Robbins E, Springer TA, Burakoff SJ: LFA1, LFA-2 and LFA-3 antigen are involved in CTL-target conjugation. J Immunol 1984, 132:2180–2182.

    PubMed  CAS  Google Scholar 

  15. Hildreth JEK, Gotch FM, Hildreth PDK, McMichael AJ: A human lymphocyte-associated antigen involved in cell-mediated lympholysis. Eur J Immunol 1983, 13:202–208.

    Article  PubMed  CAS  Google Scholar 

  16. Beatty PG, Ledbetter JA, Martin PJ, Price TH, Hansen JA: Definition of a common leukocyte cell-surface antigen (Lp95–150) associated with diverse cell-mediated immune functions. J Immunol 1983, 131:2913–2918.

    PubMed  CAS  Google Scholar 

  17. Kohl S, Springer TA, Schmalstieg FS, Loo LS, Anderson DC: Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency. J Immunol 1984, 133:2972–2978.

    PubMed  CAS  Google Scholar 

  18. Miedema F, Tetteroo PAT, Hesselink WG, Werner G, Spits H, Melief CJM: Both Fc receptors and lymphocytefunction-associated antigen on human g lymphocytes are required for antibody-dependent cellular cytotoxicity (K-cell activity). Eur J Immunol 1984, 14:518–523.

    Article  PubMed  CAS  Google Scholar 

  19. Miedema F, Tetteroo PAT, Hesselink WG, Werner G, Spits H, Melief CJM: Both Fc receptors and lymphocytefunction-associated antigen on human g lymphocytes are required for antibody-dependent cellular cytotoxicity (K-cell activity). Eur J Immunol 1984, 14:518–523.

    Article  PubMed  CAS  Google Scholar 

  20. Miedema F, Tetteroo PAT, Hesselink WG, Werner G, Spits H, Melief CJM: Both Fc receptors and lymphocytefunction-associated antigen on human g lymphocytes are required for antibody-dependent cellular cytotoxicity (K-cell activity). Eur J Immunol 1984, 14:518–523.

    Article  PubMed  CAS  Google Scholar 

  21. Kürzinger K, Springer TA: Purification and structural characterization of LFA-1, a lymphocyte function-associated antigen, and Mac-1, a related macrophage differentiation antigen. J Biol Chem 1982, 257:12412–12418.

    PubMed  Google Scholar 

  22. Trowbridge IS, Omary MB: Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. J Exp Med 1981, 154:1517–1524.

    Article  PubMed  CAS  Google Scholar 

  23. Kürzinger K, Ho MK, Springer TA: Structural homology of a macrophage differentiation antigen and an antigen involved in T-cell-mediated killing. Nature 1982, 296:668–670.

    Article  PubMed  Google Scholar 

  24. Springer TA, Teplow D, Dreyer WJ: The LFA-1, Mac-1 family of leuckoyte adhesion glycoproteins: alpha subunit sequence homology and unexpected relation to leukocyte interferon. 1984, submitted for publication.

    Google Scholar 

  25. Crowley CA, Curnutte JT, Rosin RE, Andre-Schwartz J, Gallin JI, Klempner M, Snyderman R, Southwick FS, Stossel TP, Babior BM: An inherited abnormality of neutrophil adhesion: Its genetic transmission and its association with a missing protein. New Eng J Med 1980, 302:1163–1168.

    Article  PubMed  CAS  Google Scholar 

  26. Buchanan MR, Crowley CA, Rosin RE, Gimbrone MA, Babior BM: Studies on the interaction between GP-180deficient neutrophils and vascular endothelium. Blood 1982, 60:160–165.

    PubMed  CAS  Google Scholar 

  27. Arnaout MA, Pitt J, Cohen HJ, Melamed J, Rosen FS, Colten HR: Deficiency of a granulocyte-membrane glycoprotein (gp150) in a boy with recurrent bacterial infections. New Eng J Med 1982, 306:693–699.

    Article  PubMed  CAS  Google Scholar 

  28. Anderson DC, Schmalstieg FC, Kohl S, Arnaout MA, Hughes BJ, Tosi MF, Buffone GJ, Brinkley BR, Dickey WD, Abramson JS, Springer TA, Boxer LA, Hollers JM, Smith CW: Abnormalities of polymorphonuclear leukocyte function associated with a heritable deficiency of a high molecular weight surface glycoproteins (GP138): Common relationship to diminished cell adherence. J Clin Invest 1984, 74:536–551.

    Article  PubMed  CAS  Google Scholar 

  29. Dana N, Todd III, RF, Pitt J, Springer TA, Arnaout MA: Deficiency of a surface membrane glycoprotein (Mol) in man. J Clin Invest 1984, 73:153–159.

    Article  PubMed  CAS  Google Scholar 

  30. Dana N, Todd III, RF, Pitt J, Springer TA, Arnaout MA: Deficiency of a surface membrane glycoprotein (Mol) in man. J Clin Invest 1984, 73:153–159.

    Article  PubMed  CAS  Google Scholar 

  31. Beatty PG, Harlan JM, Rosen H, Hansen JA, Ochs HD, Price TD, Taylor RF, Klebanoff SJ: Absence of monoclonal-antibody-defined protein complex in boy with abnormal leucocyte function. Lancet 1984, L535–537.

    Google Scholar 

  32. Ross GD, Thompson RA, Walport MJ, Springer TA, Watson JV, Ward RHR, Lida J, Newman SL, Harrison RA, Lachmann PJ: Identification of a genetic deficiency of leukocyte membrane complement receptor type 3 (CR3, an iC3b receptor) and its association with increased susceptibility to bacterial infections. 1984, submitted for publication.

    Google Scholar 

  33. Fischer A, Seger R, Durandy A, Grospierre B, Virelizier JL, Griscelli C, Fischer E, Kazatchkine M, Bohler MC, Descamps-Latscha B, Trung PH, Olive D, Mawas C: Deficiency of the adhesive protein complex LFA-1, C3bi complement receptor, p150,95 in a girl with recurrent bacterial infections. 1984, submitted for publication.

    Google Scholar 

  34. Anderson DC, Schmalstieg FE, Shearer W, Freeman K, Kohl S, Smith CW, Springer T: Abnormalities of PMN/ Monocyte function and recurrent infection associated with a heritable deficiency of adhesive surface glycoproteins. Fed Proc 1984, in press.

    Google Scholar 

  35. Dana N, Todd R, Pitt J, Cotten HR, Arnaout MA: Evidence that Mol (a surface glycoprotein involved in phagocytosis) is distinct from the C3bi receptor. Immunobiology 1983, 164:205–206.

    Google Scholar 

  36. Shapiro SZ, Young JR: An immunochemical method for mRNA purification. J Bio Chem 1981, 256:1495–1498.

    CAS  Google Scholar 

  37. Anderson DJ, Blobel G: Biosynthesis of acetylcholine receptor in vitro. Meth Enzymol 1983, 96:111–120.

    Article  PubMed  CAS  Google Scholar 

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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Springer, T.A., Sastre, L., Schmalstieg, F., Anderson, D. (1985). Inherited LFA-1, Mac-1 deficiency and its molecular biology. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5020-7_12

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  • DOI: https://doi.org/10.1007/978-94-009-5020-7_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8723-0

  • Online ISBN: 978-94-009-5020-7

  • eBook Packages: Springer Book Archive

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