Clinico-Epidemiological Features of Adult T-Cell Leukemia/Lymphoma (ATLL) in Japan: Relations of HTLV-I/ATLV Infection to ATLL Manifestation

  • Kazuo Tajima
  • Suketami Tominaga
Part of the Developments in Oncology book series (DION, volume 31)


The age-adjusted death rate of malignant lymphomas in the Kyushu district including Okinawa Prefecture, the southern-most district in Japan, was twice as high as those for other districts of Japan.1 A nationwide survey2 showed that the excess rate of mortality from malignant lymphomas in Kyushu was due to the high incidence of adult T-cell leukemia/lymphoma (ATLL).3 The Kyushu district seemed to be the most typical endemic area of ATLL in the world. It was estimated that more than 300 new cases of ATLL will occur every year in the Kyushu district. In addition to the Kyushu district, many cases of ATLL have been observed in other districts of Japan2 and in the northern part of Taiwan.4 It was reported5 that cases similar to Japanese ATLL were found among Caribbean people who might have originated in central Africa.


HTLV Infection Natural Transmission ATLL Patient HTLV Carrier Kyushu District 
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  1. 1.
    Tajima K, Tominaga S, Kuroishi T, Shimizu H, Suchi H. 1979. Geographical features and epidemiological approach to endemic T-cell leukemia/lymphoma in Japan. Jpn J Clin Oncol 9:495–504.Google Scholar
  2. 2.
    The T- and B-cell Malignancy Study Group. Statistical analysis of immunologic, clinical and histopathologic data on lymphoid malignancies in Japan. Jpn J Clin Oncol 11:15–38.Google Scholar
  3. 3.
    Uchiyama T, Yodoi J, Sagawa Wf Takatsuki Kr Uchino H. 1977. Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood 50:481–492.Google Scholar
  4. 4.
    Pan I-H (personal communication).Google Scholar
  5. 5.
    Catovsky D, Greaves MF, Rose M, Galton DAG, Goolden AWG, McClusky DR, White JM, Lampert I, Bourikas G, Ireland R, Brownell AI, Bridges JM, Blattner WA, Gallo RC. 1982. Adult T-cell lymphoma-leukaemia in blacks from the West Indies. Lancet 1:639–643.PubMedCrossRefGoogle Scholar
  6. 6.
    Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77:7415–7419.PubMedCrossRefGoogle Scholar
  7. 7.
    Reitz MS, Poiesz BJ, Ruscetti FW, Gallo RC. 1981. Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes. Proc Natl Acad Sci USA 78:1887–1891.PubMedCrossRefGoogle Scholar
  8. 8.
    Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita K, Shirakawa S, Miyoshi I. 1981. Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 78:6476–6480.PubMedCrossRefGoogle Scholar
  9. 9.
    Yoshida M, Miyoshi I, Hinuma Y. 1982. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 79:2031–2035.PubMedCrossRefGoogle Scholar
  10. 10.
    T- and B-cell Malignancy Study Group. Clinical and epidemiological findings of adult T-cell leukemia/lymphoma in Japan: a nation-wide study II. (unpublished)Google Scholar
  11. 11.
    Hinuma Y, Komoda H, Chosa T, Kondo T, Kohakura M, Takenaka T, Kikuchi M, Ichimaru M, Yunoki K, Sato I, Matsuo R, Takiuchi Y, Uchino H, Hanaoka M. 1982. Antibodies on adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide sero-epidemiological study. Int J Cancer 29:631–635.PubMedCrossRefGoogle Scholar
  12. 12.
    Tajima K, Tominaga S, Suchi T, Kawagoe T, Komoda H, Hinuma Y, Oda T, Fujita K. 1982. Epidemiological analysis of the distribution of antibody to adult T-cell leukemia-virus-associated antigen: possible horizontal transmission of adult T-cell leukemia virus. Gann Monogr Cancer Res 73:893–901.Google Scholar
  13. 13.
    Maeda Y, Furukawa M, Takehara Y, Yoshimura K, Miyamoto K, Matsuura T, Morishima Y, Tajima K, Okochi K, Hinuma Y. 1984. Prevalence of possible adult T-cell leukemia virus-carriers among volunteer blood donors in Japan: a nation-wide study. Int J Cancer 33:717–720.PubMedCrossRefGoogle Scholar
  14. 14.
    Tajima K, Hinuma Y. 1984 (in press). Epidemiological features of adult T-cell leukemia virus. In: Pathological Aspects of Cancer Epidemiology: Immunological, Virological, Endocrinological and Genetical Factors.Google Scholar
  15. 15.
    Ministry of Health and Welfare. Vital Statistics Japan Series, Vol 2, 1978–1982.Google Scholar
  16. 16.
    Hinuma Y, Gotoh Y, Sugamura K, Nagata K, Gotoh T, Nakai N, Kamada N, Matsumoto T, Kinoshita K. 1982. A retrovirus associated with human adult T-cell leukemia: in vitro activation. Gann 73:341–344.PubMedGoogle Scholar
  17. 17.
    Gotoh Y, Sugamura K, Hinuma Y. 1982. Healthy carriers of a human retrovirus, adult T-cell leukemia virus (ATLV): demonstration by clonal culture of ATLV-carrying T cells from peripheral blood. Proc Natl Acad Sci USA 79:4780–4782.PubMedCrossRefGoogle Scholar
  18. 18.
    Hinuma Yr Chosa T, Komoda H, Mori I, Suzuki T, Tajima K, Pan I-H, Lee M. 1983. Spradic retrovirus (ATLV)-seropositive individuals outside Japan. Lancet 1:824–825.PubMedCrossRefGoogle Scholar
  19. 19.
    Zeng Y, Lan XY, Fang J, Wang PZ, Wang YR, Sui YF, Wang ZT, Hu RJ, Hinuma Y. 1984. HTLV antibody in China. Lancet 1:799–800.PubMedCrossRefGoogle Scholar
  20. 20.
    Tajima K, Tominaga S, Suchi T. 1984 (in press). Malignant lymphomas in Japan: epidemiological analysis on adult T-cell leukemia/lymphoma. Haematol Oncol 2.Google Scholar
  21. 21.
    Kinoshita K, Hino S, Amagasaki T, Ikeda S, Yamada Y, Suzuyama J, Momita S, Toriya K, Kamihira S, Ichimaru M. 1984. Demonstration of adult T-cell leukemia virus antigen in milk from three sero-positive mothers. Gann 75:103–105.PubMedGoogle Scholar
  22. 22.
    Nakano S, Ichijo M, Hinuma Y, et al. Search for possible routes of vertical and horizontal transmission of adult T-cell leukemia virus, (unpublished)Google Scholar
  23. 23.
    Okochi K, Sato H, Hinuma Y. 1984 (in press). A retrospective study on transmission of adult T-cell leukemia virus by blood transfusion: seroconversion in recipient. Vox Sang.Google Scholar
  24. 24.
    Ichimaru M, Kinoshita K, Kamihira S, Yamada Y, Oyakawa Y, Amagasaki T, Kusano M. 1982. Familial disposition of adult T-cell leukemia and lymphoma. Gann Monogr Cancer Res 28:185–195.Google Scholar
  25. 25.
    Tajima K, Akaza T, Koike K, Hinuma Y, Suchi T, Tominaga S. 1984. HLA antigens and adult T-cell leukemia virus infection: a community based study in the Goto Islands, Japan. Jpn J Clin Oncol 14:347–352.PubMedGoogle Scholar
  26. 26.
    Tajima K, Tominaga S, Suchi T, Fujita K, Oda T, Tochikura T, Hinuma Y. 1984 (in press). Sero-epidemiological analysis of antibody expression against natural infection with ATLV amongst healthy inhabitants in the Goto Islands, Japan: an interim report. In: Manipulation of Host Defence Mechanisms—Fifth Symposium Proceedings. Haddon RA, ed. Excerpta Medica Asia.Google Scholar
  27. 27.
    Miyamoto T, Hino S, Muneshita T. 1983. Seroepidemiological studies of antibody against antigens expressed on adult T-cell leukemia cells in Nagasaki area. In: Leukemia Reviews International. Rich MA, ed. Marcel Dekker, p105.Google Scholar
  28. 28.
    Tajima K, Tominaga S, Shimizu H, Suchi T. 1981. A hypothesis on the etiology of adult T-cell leukemia/lymphoma. Gann Monogr Cancer Res 72:684–691.Google Scholar
  29. 29.
    Tajima K, Fujita K, Tsukidate S, Oda T, Tominaga S, Suchi T, Hinuma Y. 1983. Seroepidemiological studies on the effects of filarial parasites on infestation of adult T-cell leukemia virus in the Goto Islands, Japan. Gann Monogr Cancer Res 74:188–191.Google Scholar
  30. 30.
    Seiki M, Hattori S, Hirayama Y, Yoshida M. 1983. Human adult T-cell leukemia virus: complete nucleotide sequence of the pro-virus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA 80:3618–3622.PubMedCrossRefGoogle Scholar
  31. 31.
    Kinoshita K, Hino S, Amagasaki T, Yamada Y, Kamihira S, Ichimaru M, Munehisa Y, Hinuma Y. 1982. Development of adult T-cell leukemia-lymphoma (ATL) in two anti-ATL-associated antigen-positive healthy adults. Gann Monogr Cancer Res 73:684–685.Google Scholar

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© Martinus Nijhoff Publishers, Dordrecht 1985

Authors and Affiliations

  • Kazuo Tajima
  • Suketami Tominaga

There are no affiliations available

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