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New Uses for Agonist-Antagonists in Anesthesia

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Anesthesiology: Today and Tomorrow

Part of the book series: Developments in Critical Care Medicine and Anaesthesiology ((DCCA,volume 9))

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Abstract

The introduction of neuroleptanalgesia by De Castro and Mundeleer opened a new epoch in anesthesiology, since many of the side effects associated with the deep planes of inhalational anesthetics were obviated. The separate and appropriate dosing of droperidol and fentanyl allowed the safe conduct of surgery with minimal adverse endocrine and metabolic sequelae. The introduction of benzodiazepines provided another safe, alternate technique; ataract-analgesia with the combination of diazepam-fentanyl or flunitrazepam-fentanyl has been used during the past two decades. The introduction of the highly specific narcotic antagonist, naloxone, further enhanced the safety of neuroleptor ataract-analgesia, since reversal of the respiratory depression could be carried out with safety.

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Authors
  1. Elemer K. Zsigmond M.D.
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Editors and Affiliations

  1. Department of Anesthesiology, The University of Utah Medical School, 84132, Salt Lake City, Utah, USA

    Theodore H. Stanley M.D.  & W. Clayton Petty M.D.  & 

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© 1985 Martinus Nijhoff Publishers, Dordrecht

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Zsigmond, E.K. (1985). New Uses for Agonist-Antagonists in Anesthesia. In: Stanley, T.H., Petty, W.C. (eds) Anesthesiology: Today and Tomorrow. Developments in Critical Care Medicine and Anaesthesiology, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5000-9_11

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  • DOI: https://doi.org/10.1007/978-94-009-5000-9_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8714-8

  • Online ISBN: 978-94-009-5000-9

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