Abstract
In cases of plutonium contamination, performance of a microdosimetric evaluation is important from the radiation protection point of view because of the short range of the emitted alpha particles. This makes it necessary to obtain accurate data on the microdistribution of plutonium at various times after intake. Since plutonium is essentially a bone surface seeker, most of the data available in the literature refer to the plutonium microdistribution near endosteal and periosteal bone surfaces (1,2,3,4,5,6,7,8,9,10,11,12) considered the critical tissues for the induction of bone osteosarcomas. There is a paucity of data on plutonium microdistribution in adult cortical bone. The purpose of this study was to obtain data on plutonium microdistribution in cortical bone, which consists of a mineralized component and a soft tissue component, lining the forming and resorbing cavities and the Haversian and Volkmann’s canals. The soft tissue consists of various bone cells (13,14) considered to be at risk from radiation-induced osteosarcomas including bone lining cells and “osteoprogenitor” cells. Cortical bone is a dynamic structure subject to continuous remodeling: the removal of compact bone is followed by the replacement of a new Haversian system or osteon. Alpha irradiation of the remodeling units could promote pathological alterations in the skeleton (radiation osteodystrophy) as well as the induction of osteosarcomas (15,13,7,16).
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Ingrao, G., Jee, W.S.S. (1985). Pu Microdistribution Study in Cortical Bones of Beagle Dogs. In: Priest, N.D. (eds) Metals in Bone. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4920-1_18
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DOI: https://doi.org/10.1007/978-94-009-4920-1_18
Publisher Name: Springer, Dordrecht
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