Skip to main content
SpringerLink
Log in
Book cover

Future Aspects in Contraception pp 189–201Cite as

Mechanism of action of gonadotrophin releasing hormone in the pituitary and gonads

  • Chapter

  • 69 Accesses

Abstract

Gonadotrophin releasing hormone (GnRH) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) biosynthesis and release from pituitary gonadotrophs. Paradoxical antifertility effects of GnRH analogues in vivo demonstrated that GnRH also exerts direct stimulatory and inhibitory gonadal effects1–13.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hillensjö, T. and Lemaire, W. J. (1980). Nature (London), 287, 145

    Article  Google Scholar 

  2. Clark, M. R., Thibier, C., Marsh, J. M. and Lemaire, W. J. (1980). Endocrinology, 107, 17

    Article  PubMed  CAS  Google Scholar 

  3. Hsueh, A. J. W. and Jones, P. B. C. (1981). Endocr. Rev., 2, 437

    Article  PubMed  CAS  Google Scholar 

  4. Knecht, M. and Catt, K. J. (1981). Science, N. Y., 214, 1346

    Article  CAS  Google Scholar 

  5. Ekholm, C., Hillensjö, T. and Isaksson, O. (1981). Endocrinology, 108, 2022

    Article  PubMed  CAS  Google Scholar 

  6. Hunter, M. G., Sullivan, M.H.F., Dix, C. J., Aldred, L. F. and Cooke, B. A. (1982) Mol. Cell. Endocrinol., 27, 31

    Article  PubMed  CAS  Google Scholar 

  7. Jones, P. B. C. and Hsueh, A. J. W. (1982). Endocrinology, 111, 713

    Article  PubMed  CAS  Google Scholar 

  8. Dekel, N., Sherizly, I., Tsafriri, A. and Naor, Z. (1983). Biol. Reprod., 28, 161

    Article  PubMed  CAS  Google Scholar 

  9. Hsueh, A.J.W., Bambino, T. H., Zhuang, I. Z., Welsh, T. H. and Ling, N. C. (1983). Endocrinology, 112, 1653

    Article  PubMed  CAS  Google Scholar 

  10. Knecht, M., Ranta, T., Naor, Z. and Catt, K. J. (1983). In Greenwold, G. S. and Terranova, P. F. (eds.) Factors Regulating Ovarian Function, p. 225. ( New York: Raven Press )

    Google Scholar 

  11. Molcho, J., Zakut, H. and Naor, Z. (1984). Endocrinology, 114, 1048

    Article  PubMed  CAS  Google Scholar 

  12. Molcho, J., Eli, Y., Zakut, H. and Naor, Z. (1984). Endocrinology, 114, 2382

    Article  PubMed  CAS  Google Scholar 

  13. Zilberstein, M., Zakut, H., Eli, Y. and Naor, Z. (1984). Endocrinology, 114, 2374

    Article  PubMed  CAS  Google Scholar 

  14. Naor, Z., Koch, Y., Chobsieng, P. and Zor, U. (1975). FEBS Lett., 58, 318

    Article  PubMed  CAS  Google Scholar 

  15. Naor, Z., Zor, U., Meidan, R. and Koch, Y. (1978). Am. J. Physiol., 235, E37

    PubMed  CAS  Google Scholar 

  16. Naor, Z. (1982). In Tixier-Vidal, A. and Richard, Ph. (eds.) Multihormonal Regulation in Neuroendocrine Cells. Vol. 110, p. 395. (INSERM)

    Google Scholar 

  17. Hokin, M. R. and Hokin, L. E. (1953). J. Biol. Chem., 203, 967

    PubMed  CAS  Google Scholar 

  18. Michell, R. H. (1975). Biochim. Biophys. Acta, 415, 81

    PubMed  CAS  Google Scholar 

  19. Berridge, M. J., Dawson, R.M.C., Downes, C. P., Heslop, J. P. and Irvine, R. F. (1983). Biochem. J., 212, 473

    PubMed  CAS  Google Scholar 

  20. Nishizuka, Y. (1984). Nature (London), 308, 693

    Article  CAS  Google Scholar 

  21. Downes, P. and Michell, R. H. (1982). Cell Calcium, 3, 467

    Article  PubMed  CAS  Google Scholar 

  22. Takai, Y., Kishimoto, A., Iwasa, Y., Kawahara, Y., Mori, T. and Nishizuka, Y. (1979). J. Biol. Chem., 254, 3692

    PubMed  CAS  Google Scholar 

  23. Streb, H., Irvine, R. F., Berridge, M. J. and Schulz, I. (1983). Nature (London), 306, 67

    Article  CAS  Google Scholar 

  24. Salmon, D. M. and Honeyman, T. W. (1980). Nature (London), 284, 344

    Article  CAS  Google Scholar 

  25. Hokin-Neaverson, M. and Sadeghian, K. (1984). J. Biol. Chem., 259, 4346

    PubMed  CAS  Google Scholar 

  26. Fain, J. N. (1982). In Kohn, L. D. (ed.) Hormone Receptors, p. 237. ( Chichester: Wiley )

    Google Scholar 

  27. Naor, Z. and Yavin, E. (1982). Endocrinology, 111, 1615

    Article  PubMed  CAS  Google Scholar 

  28. Snyder, G. D. and Bleasdale, J. E. (1982). Mol. Cell. Endocrinol., 28, 55

    Article  PubMed  CAS  Google Scholar 

  29. Raymond, V., Leung, P. C. K., Veilleux, R., Lefevre, G. and Labrie, F. (1984). Mol. Cell. Endocrinol., 36, 157

    Article  PubMed  CAS  Google Scholar 

  30. Kiesel, L. and Catt, K. J. (1984). Arch. Biochem. Biophys., 231, 202

    Article  PubMed  CAS  Google Scholar 

  31. Monaco, M. E. and Woods, D. (1983). J. Biol. Chem., 258, 15125

    PubMed  CAS  Google Scholar 

  32. Murphy, R. C., Hammarstrom, S. and Samuelsson, B. (1979). Proc. Natl. Acad. Sci. USA, 76, 4275

    Article  PubMed  CAS  Google Scholar 

  33. Naor, Z., Vanderhoek, J. Y., Lindner, H. R. and Catt, K. J. (1983). In Samuelsson, B., Paoletti, R. and Ramwell, P. (eds.) Advances in Prostaglandin Thromboxane and Leukotriene Research. Vol. 12, p. 259. ( New York: Raven Press )

    Google Scholar 

  34. Vanderhoek, J. Y., Kiesel, L., Naor, Z. and Catt, K. J. (1984). Prostaglandins Leukotrienes Med., 15, 375

    Article  CAS  Google Scholar 

  35. Naor, Z., Leifer, A. M. and Catt, K. J. (1980). Endocrinology, 107, 1438

    Article  PubMed  CAS  Google Scholar 

  36. Conn, P. M., Marian, J., McMillian, M., Stern, J., Rogers, D., Hamby, M., Penna, A. and Grant, E. (1981). Endocr. Rev., 2, 174

    Article  PubMed  CAS  Google Scholar 

  37. Conn, P. M., Chafouleas, J. G., Rogers, D. and Means, A. R. (1981). Nature (London), 292, 264

    Article  CAS  Google Scholar 

  38. Naor, Z. and Catt, K. J. (1981). J. Biol. Chem., 256, 2226

    PubMed  CAS  Google Scholar 

  39. Naor, Z., Koch, Y., Bauminger, S. and Zor, U. (1975). Prostaglandins, 9, 211

    Article  PubMed  CAS  Google Scholar 

  40. Ojeda, S. R., Naor, Z. and Negro-Vilar, A. (1979). Prostaglandins Leukotrienes Med., 2, 249

    CAS  Google Scholar 

  41. Snyder, G. D., Capdevila, J., Chacos, N., Manna, S. and Falck, J. R. (1983). Proc. Natl. A cad. Sci. USA, 80, 3 504

    Google Scholar 

  42. Kuo, J. F., Andersson, R.G.G., Wise, B. C., Mackerlova, L., Salomonsson, I., Brackett, N. L., Katoh, N., Shou, M. and Wrenn, A. W. (1980). Proc. Natl. Acad. Sci. USA, 77, 7039

    Article  PubMed  CAS  Google Scholar 

  43. Sutton, C. A. and Martin, T. F. J. (1982). Endocrinology, 110, 1273

    Article  PubMed  CAS  Google Scholar 

  44. Rebecci, M. J. and Gershengorn, M. C. (1983). Biochem. J., 216, 287.

    Google Scholar 

  45. Mendelson, C., Dufau, M. L. and Catt, K. J. (1975). J. Biol. Chem., 250, 8818

    PubMed  CAS  Google Scholar 

  46. Zor, U. and Lamprecht, S. A. (1977). In Litwack, G. (ed.) Biochemical Actions of Hormones. Vol. 4, p. 85. ( London: Academic Press )

    Google Scholar 

  47. Benabe, J. E., Spry, L. A. and Morrison, A. R. (1982). J. Biol. Chem., 257, 7430

    PubMed  CAS  Google Scholar 

  48. Marshall, P. J., Boatman, D. E. and Hokin, L. E. (1981). J. Biol. Chem., 256, 844

    PubMed  CAS  Google Scholar 

  49. Naor, Z., Zilberstein, M., Zakut, H., Lindner, H. R. and Dekel, N. (1983). Mol. Cell. Endocrinol., 31, 261

    Article  PubMed  CAS  Google Scholar 

  50. Naor, Z., Zilberstein, M., Zakut, H. and Dekel, N. (1984). Life Sci., 35, 389

    Article  PubMed  CAS  Google Scholar 

  51. Ranta, T., Knecht, M., Darbon, J. M., Baukal, A. J. and Catt, K. J. (1983). Endocrinology, 113, 427

    Article  PubMed  CAS  Google Scholar 

  52. Nillius, S. J., Bergquist, C. and Wide, L. (1978). Contraception, 17, 537

    Article  Google Scholar 

  53. Yen, S.S.C. (1983). Fertil. Steril., 39, 257

    PubMed  CAS  Google Scholar 

  54. Linde, R., Doelle, G. C., Alexander, N., Krichner, F., Vale, W., Rivier, J. and Rabin, D. (1981). N. Engl. J. Med., 305, 663

    Article  PubMed  CAS  Google Scholar 

  55. Bex, F. J. and Corbin, A. (1984). In Martini, L. and Ganong, W. F. (eds.) Frontiers in Neuroendocrinology. Vol. 8, p. 85. ( New York: Raven Press )

    Google Scholar 

  56. Reich, R., Kohen, F., Naor, Z. and Tsafriri, A. (1983). Prostaglandins, 26, 1011

    Article  PubMed  CAS  Google Scholar 

  57. Sharp, R. M., Fraser, H. M., Cooper, I. and Rommerts, F.F.G. (1981). Nature (London), 290, 785

    Article  Google Scholar 

  58. Ying, S. Y., Ling, N., Bohlen, P. and Guillemin, R. (1981). Endocrinology, 108, 1206

    Article  PubMed  CAS  Google Scholar 

  59. Dutlow, C. M. and Millar, R. P. (1981). Biochem. Biophys. Res. Commun., 101, 486

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Z. Naor
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Molcho
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Hermon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Zer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Zilberstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. H. Zakut
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

B. Runnebaum T. Rabe L. Kiesel

Rights and permissions

Reprints and permissions

Copyright information

© 1985 MTP Press Limited

About this chapter

Cite this chapter

Naor, Z., Molcho, J., Hermon, J., Zer, J., Zilberstein, M., Zakut, H. (1985). Mechanism of action of gonadotrophin releasing hormone in the pituitary and gonads. In: Runnebaum, B., Rabe, T., Kiesel, L. (eds) Future Aspects in Contraception. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4916-4_16

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-4916-4_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8678-3

  • Online ISBN: 978-94-009-4916-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation