The Clinical Relevance of in vitro Investigations for Percutaneous Absorption
When we apply a drug preparation to diseased skin, the clinical response arises from a sequence of three drug-related processes — release of the medicament from the vehicle, followed by its penetration through the skin barriers and finally its activation of the desired pharmacological response. Effective topical therapy optimizes these processes as they are affected by three components — the drug, the vehicle and the skin1.
KeywordsStratum Corneum Skin Barrier Skin Permeation Percutaneous Absorption Skin Secretion
Unable to display preview. Download preview PDF.
- 1.Barry, B.W. (1983). Dermatological Formulations: Percutaneous Absorption. ( New York and Basel: Dekker )Google Scholar
- 2.Higuchi, T. (1977). Prodrug, molecular structure and percutaneous delivery. In Roche, B. (ed.), Design of Biopharmaceutical Properties Through Prodrugs and Analogs. ( Washington, DC: American Pharmaceutical Association ), pp. 409–421Google Scholar
- 4.Higuchi, T. (1960). Physical chemical analysis of percutaneous absorption process from creams and ointments. J. Soc. Cosmetic Chem., 11, 85–97Google Scholar
- 5.Higuchi, W.I. (1961). Diffusion in ointment bases. Proc. Am. Soc. Coll. Pharm., Teachers Seminar., 13, 162–173Google Scholar
- 9.Barry, B. W. and Woodford, R. (1978). Activity and bioavailability of topical steroids. In vivo /in vitro correlations for the vasoconstrictor test. J. Clin. Pharm., 3, 43–65Google Scholar
- 10.Katz, M. and Poulsen, B.J. (1971). Absorption of drugs through the skin. In Brodie, B.B. and Gillette, J. (eds.), Concepts in Biochemical Pharmacology. (Berlin, Heidelberg, New York: Springer) Handbook of Experimental Pharmacology, vol. 28, pt. 1, pp. 103–174Google Scholar
- 11.Poulsen, B.J. (1972). Diffusion of drugs from topical vehicles: an analysis of vehicle effects. In Montagna, W., Van Scott, E. J. and Stoughton, R.B. (eds.), Pharmacology and the Skin. (New York: Appleton-Century-Crofts) (Advances in Biology of Skin, vol. 12, pp. 495–509 )Google Scholar
- 12.Scheuplein, R. J. (1978a). The skin as a barrier, skin permeation, site variations in diffusion and permeability. In Jarrett, A. (ed.), The Physiology and Pathophysiology of the Skin .(London, New York, San Francisco: Academic Press), vol. 5, pp. 1669–1692, 1693–1730, 1731–1752Google Scholar