The Clinical Relevance of in vitro Investigations for Percutaneous Absorption

  • B. W. Barry


When we apply a drug preparation to diseased skin, the clinical response arises from a sequence of three drug-related processes — release of the medicament from the vehicle, followed by its penetration through the skin barriers and finally its activation of the desired pharmacological response. Effective topical therapy optimizes these processes as they are affected by three components — the drug, the vehicle and the skin1.


Stratum Corneum Skin Barrier Skin Permeation Percutaneous Absorption Skin Secretion 
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© MTP Press Limited 1985

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  • B. W. Barry

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